Background The goal of this study was to design structural mimics of HIV-1 epitopes that have the potential to induce broadly neutralizing antibodies (bnAbs). The structure of the gp41 membrane proximal external region (MPER), targeted by three bnAbs, requires further definition. Experiments were designed to select epitopes with enhanced binding to MPER bnAbs, to identify neutralization-competent MPER structures, and to determine if selected MPER epitopes can broaden the immune response as potential vaccines. Methods
Carl R. Alving合作论文数Walter Reed Army Institute of Research2
Mangala Rao合作论文数2
Venigalla B. Rao合作论文数Department of Biology, The Catholic University of America2
Mary Marovich合作论文数2Kristina Peachman合作论文数Walter Reed Army Institute of Research2
Menglou Rao合作论文数1S. McCormack合作论文数1Q. Li合作论文数1
Ankit Saxena合作论文数NHLBI, NIH1
Shivachandra Sathish Bhadravati合作论文数Clinical Bacteriology Laboratory, Indian Veterinary Research Institute (IVRI),1
Laetitia Nelson合作论文数1
Jerome H. Kim合作论文数International Vaccine Institute1
Victoria R Polonis合作论文数1Jeffrey R. Currier合作论文数1
Gustavo Kijak合作论文数AstraZeneca1
Lindsay Wieczorek合作论文数Military HIV Research Program, Henry M. Jackson Foundation1
