Abstract Objectives To investigate if different methods of pancreatoduodenectomy (with or without pyloric preservation) would have different impacts on postoperative nutrition and body composition changes among pancreatic cancer patients. Methods Demographic and clinicopathological data, perioperative data were collected, body composition (e.g. skeletal muscle cross‐sectional area [CSA], visceral fat area [VFA]) were evaluated with abdominal CT before and after surgery. Sarcopenia patients' proportion changes were also recorded. Results The hospital stay in the PRPD group was significantly less than that in the PPPD group (p < 0.05). A significant difference was found in CSA, skeletal muscle index (SMI), VFA, VFA/CSA and albumin (ALB) in both groups between preoperative, 3, and 12 months after surgery. The loss of visceral fat in the PRPD group was more prominent than that in the PPPD group at 3 months and 12 months after surgery (p < 0.05). VFA/CSA was higher in the PPPD group than in the PRPD group (3 months: p < 0.05, 12 months: p < 0.001). The proportion of sarcopenic patients increased significantly over time in the PPPD and PRPD groups (p < 0.001). Conclusions Postoperative CSA and VFA continued to significantly decrease in both PPPD and PRPD groups, while the incidence of sarcopenia continued to increase. Compared with PRPD, PPPD has a protective effect on visceral fat. PPPD may contribute to better maintaining visceral fat mass and blood ALB levels. CT quantification can be an objective and effective method to evaluate the nutritional status of pancreatic cancer patients during the pre‐ and postoperative period and can provide a useful objective basis for guiding clinical treatment.

Objective To detect the expression of ADAM8 mRNA and protein in gastric carcinoma and to investigate the correlation between ADAM8 gene expression and clinicopathological features.Methods ADAM8 was detected in 100 cases of gastric carcinoma and 20 cases of normal gastric tissues by reverse transcriptase-polymerase chain reaction(RT-PCR)and Western blotting.The correlation between the ADAM8 expression and clinicopathological features was analyzed.Results Immunohistochemical analysis showed that the expression rate of ADAM8 in gastric carcinoma was increased significantly[86％ (86/100),P＜0.05] as compared with that in normal gastric tissues[30 ％ (6/20)].ADAM8 mRNA expression level was (0.767±0.129) in gastric carcinoma and (0.192±0.127) in normal gastric tissue,with a significant difference(P＜0.05).Western blotting showed that the ADAM8 protein expression level was (0.659±0.027) in gastric carcinoma and (0.236±0.074) in normal gastric specimens,with a significant difference(P＜0.01).ADAM8 mRNA and protein expression levels in gastric carcinoma tissues were significantly higher than those in normal gastric tissues(P＜0.05).There were significant correlations between the expression level and diameter of the tumor,clinical stage,differentiation,biological behaviors,and lymphatic metastasis(all P＜0.05),but no significant correlations were found between the expression level and gender,age (both P＞ 0.05).Conclusion Overexpression of ADAM8 in gastric carcinoma may be associated with tumor progression.