CONCLUSION Oxybutynin topical gel (Gelnique) offers a modestly effective alternative to oral medications for treatment of overactive bladder. How it compares in efficacy to other formulations of oxybutynin or to any other antimuscarinic drug approved to treat overactive bladder remains to be determined. The gel may cause a lower incidence of local skin reactions than the transdermal patch formulation of oxybutynin and might, like the patch, cause less dry mouth and constipation than oral formulations.

The following articles from The Medical Letter have been selected on the basis of their importance to obstetrician- gynecologists. For information on how to subscribe to The Medical Letter, go to http://medicalletter.org/tml/obgyn.

Dronedarone (Multaq - Sanofi-Aventis) has been approved by the FDA for oral treatment of atrial fibrillation and flutter. Amiodarone (Cordarone, and others) is the most effective drug for this indication, but has considerable toxicity.

Another alpha1a blocker that claims to be more than just another alpha1 blocker.

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