"化工设备基础"是应用化学专业和能源化工专业的主干课程之一,其主要讲授化工设备材料的性能、分类、内压和外压薄壁容器常见筒体及封头的应力计算和强度设计、典型化工设备的原理和结构等基本知识,其中课程思政元素的融合是将"隔离'腐蚀'因素,树立正确的人生观","深植爱国情怀,培养中华民族自豪情感"、"增强民族自信心,融入伟大事业","加强自我修养,做新时代的螺丝钉"等思政元素与理论内容进行结合,提升课堂教学的质量,对学生的专业学习及价值塑造都会产生良好的推动作用.

辽宁科技学院应用化学专业经过十余年的专业综合改革与发展,在创建省一流专业方面积累了一系列经验做法.本文从专业定位,课程体系建设、立德树人机制、产教协同模式、教学信息技术运用、师资队伍建设、质量保障体系建设等方面的理念、举措与成效进行梳理和总结.

以家庭厨房废弃油脂为原料,经脱水、过滤后,用双氧水和活性白土作对废油脂进行脱色,然后与30％NaOH溶液进行皂化反应,再经盐析、水洗、干燥定型制得肥皂.对肥皂进行了相关理化指标和去污力检测,结果表明:制得的肥皂符合行业标准,去污力强.

以3,4-二羟基苯甲酸乙酯和2-氯乙基单甲醚为起始原料,经烷氧基化、硝化、还原、环化、氯化、胺化和缩合反应合成了一个含缩氨基硫脲结构的新型喹唑啉化合物,其结构经1 H NMR,13 C NMR和MS(ESI)表征.

《药物合成反应》是制药工程专业的重要主干课程之一.文章针对课程特点和人才培养要求,从教材的取舍、教学内容的优化、教学方法的多样化等方面进行初步改革与探讨.教学中通过改变原来的教学模式,激发学生学习本门课程的兴趣,提高教学质量,增强教学效果.

Taking 2-amino-5-mercapto-1,3,4-thiadiazole as raw material , we make reaction with chlorine acetanilide and o -methyl chloine acetanilide respectively by three steps , finally we get four new sulfur acetyl -amino aromatics Schiff including thiadi-azole heterocyclic compounds .The structure of synthesized compounds are comfirmed by IR ,1H NMR, MS and elemental analysis . Four compounds are inspeted for their biological activities .The results show that two compounds (4b, 4d) possess strong antibacterial activities.

To find new EGFR inhibitors, 15 novel quinazoline derivatives containing thiosemicarbazone structure were designed and synthesized from 2-amino-4,5-dimethoxybenzoic acid and formamidine acetate by the cyclization, chlorination, amination and condensation reactions. All structures of target compounds were confirmed by H-1 NMR,C-13 NMR, HRMS and elemental analysis. The in vitro anticancer activities of compounds 6a-6o against EGFR over-expressing of MCF-7(Human breast cancer), A549(Human pulmonary adenocarcinoma) and PC3(Human prostate cancer) cell lines were tested using colorimetric MTT assay. The results indicated that several compounds showed potent activity. Compounds 6a and 6o were more potent than Lapatinib, but slightly weaker than ADM against the three cell lines. The IC50 values of compounds 6a and 6o against MCF-7 cell line were 6.97 and 6.99 mu mol/L, against A549 were 5.15 and 3.11 mu mol/L and against PC3 were 2.30 and 1.42 mu mol/L, respectively. Preliminary structure-activity relationship was also discussed.

以5-氯-2-氨基苯甲酸和甲酰胺为起始原料,经环化、氯化、取代和缩合反应,合成了3个未见文献报道的含哌嗪的喹唑啉衍生物5a～5c.其结构用1 H NMR、13C NMR、ESI-MS及IR测试技术进行了表征.采用MTT法测试了化合物5a ～5c对人胃癌SGC-7901、人口腔表皮样癌KB和人纤维肉瘤HT-1080的体外抗肿瘤活性.结果表明,化合物5a～5c对人胃癌SGC-7901和人纤维肉瘤HT-1080有弱的抑制活性,而对人口腔表皮样癌KB无明显抑制活性.

Six new quinazoline derivatives 4a similar to 4f bearing thiosemicabazone have been designed and synthesized by four step reactions of cyclization, chlorination, substitution and condensation using 2-amino-4,5-dimethoxybenzoic acid and methanimidamide acetate as starting materials. Their structures were confirmed by H-1 NMR, C-13 NMR, ESI-MS, IR techniques and elemental analysis. The in vitro antitumor activities of compounds 4a similar to 4f against SGC-7901 (human gastric cancer), KB (human oral epidermoid cancer) and HT-1080 (human fibrosarcoma) cell lines were tested using colorimetric MTT assay. The preliminary results indicated that compounds 4a and 4f showed significant antitumor activity against HT1080.

合成了一种新型三头甲巯咪唑配体2,4,6-三甲基-1,3,5-三(1-甲基咪唑-2-硫)甲苯,并通过元素分析、IR、1H和13C NMR波谱确定了化合物的结构.还利用扩散法得到了该配体的一种Ag配合物,并对配合物的结构进行了分析.

Band-stop fiber-optic filters based on sampled long-period gratings (S-LPGs) have been fabricated and studied experimental.. Comparison between transmission spectra of the proposed S-LPGs and normal LPGs have been carried out. It has been found that S-LPGs possess much narrower stop bands than the corresponding normal LPGs, though their transmission spectra are similar. Experimental results also show that S-LPGs have the same strain and temperature sensitivities as normal LPGs written in the same fiber. (C) 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2401-2403, 2009 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24627

All three phenyltetrazole substituents in the molecule of the title compound, C30H24N12S3, are located on one side of the central benzene plane. The planes of the terminal phenyl groups are roughly orthogonal to the plane of the central benzene ring; the dihedral angles are 73.0 (2), 76.1 (2) and 89.3 (2)degrees. The tetrazole planes form dihedral angles of 49.1 (2), 54.1 (2) and 36.8 (2)degrees with the planes of the attached phenyl rings.

The title compound, C24H18N10S2, crystallizes with two independent molecules in the asymmetric unit. The two terminal (1-phenyltetrazol-5-yl) sulfanyl groups adopt a trans configuration with respect to the central quinoxaline ring system in both independent molecules.

The two terminal 1-methylimidazol-2-ylsulfanyl groups adopt a syn conformation with respect to the central quinoxaline ring system in the title compound, C18H18N6S2.