L'association diabète insulinodépendant (DID) - pathologie auto-immune a été décrite mais reste mal expliquée. Nous rapportons le cas d'un diabète néonatal vrai associé à une maladle auto-immune.

BACKGROUND:Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.CASE REPORT:A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.CONCLUSION:Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.

Background. - Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.Case report. - A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.Conclusion. - Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.