Two hundred and fifty outpatient cards from the general medical practice unit were analyzed to study the development of risk factors (RF) for cardiovascular diseases (CVD) in 40-49-year-old men living in Novosibirsk. The simple randomization method in a ratio of 1:2 was used to select 100 follow-up cards of men of the same age, who had undergone additional medical examination (AME) in 2008. Twenty-five case histories of 40-49-year-old men who had sustained myocardial infarction in 2009 were analyzed in the rehabilitation unit. The investigation indicated that primary health care physicians were not involved in the identification of RF for CVD; arterial hypertension (AH) was diagnosed in 13% of cases. AME diagnosed AH in 47% of cases; hereditary tainted CVD in 40%, obesity and overweight in 80%, smoking in 70%, hypercholesterolemia in 74.2%, GTG in 35%, and hypo-alpha-cholesterolemia in 7.8%; high SCORE risk was in 27.8% of 40-49-year-old men. The same RFs for CVD were observed in myocardial infarction men of the same age.

The clinical group was composed in result of the clinical examination of 163 teenagers at the age of 13-17 from 150 families. The information about their state of health was taken from the patients' cards. The information about smoking was gathered using questionnaires. According to the results, there were only 6% of practically healthy children. The most often symptoms were: undifferentiated dysplasia of connecting tissue and its features, vegetative dystonia, chronic diseases of ENT-organs, endocrinopathy among 15-17 y.o. girls. The study showed that teenager smoked in 27.6% of cases, their mothers in 38.8%, fathers in 72.2%. Familial history of cardio-vascular diseases were positive in 74% of cases. Active and passive smoking in the early age leads to the endothelium dysfunction and incipient development of arterial hypertension. Passive smoking of mothers influences as a risk factor cvardio-vascular disease development in sons, and fathers smoking influences diastolic arterial pressure of his child.

The review reflects the development of early vascular responses to the levels of the microvasculature in hypertension (AH), especially in the prediction of adverse paradoxical reactions to the histamine and acetylcholine. Acute and chronic stress exacerbates the vascular and hormonal imbalance and contributes to the progressive hypertension and early atherosclerosis. Multiorgan pathology and the presence of comorbid conditions in patients with hypertension in the Siberian region are provided by the formation of insulin resistance and the subsequent development of metabolic syndrome, as well as the presence of undifferentiated connective tissue dysplasia.

В обзоре отражено развитие ранних сосудистых реакций на уровне микроциркуляторного русла при артериальной гипертонии (АГ), особенно неблагоприятных в прогнозе парадоксальных реакций на гистамин и ацетилхолин. Острый и хронический стресс усугубляет сосудистогормональный дисбаланс и способствует прогрессированию АГ и раннему атеросклеротическому поражению сосудов. Полиорганная патология и наличие коморбидных состояний у больных АГ в сибирском регионе связаны с формированием инсулинрезистентности с последующим развитием метаболического синдрома, а также наличием недифференцированной дисплазии соединительной ткани.

128 adolescents (14,2±0,21 years old) have been examined, the group of 37 patients with unstable arterial pressure was selected. The correct QT-interval decrement and electrical remodeling of left ventricle features in the group of adolescents with unstable arterial pressure has been observed. In this group vascular response to histamine was reduced, on the other hand, the vascular reactivity to norepinephrine was increased.

AIM:To study manifestations of vegetative dystonia in children of probands from families with hereditary IHD load regarding the main risk factors.MATERIALS AND METHODS:44 individuals aged 21 +/- 0.7 years were selected out of 111 children from 103 examined families the fathers of which had transmural or macrofocal myocardial infarction at the age under 50. 22 of 44 examinees had syndrome of vegetovascular dystonia (VVD).RESULTS:Children of probands with family history of cardiovascular disease and having VVD had levels of cholesterol, triglycerides and apoB higher, but HDLP cholesterol lower than those free of VVD. In daughters of the probands insulin and hydrocortisone levels were high whereas sons with VVD had only insulin levels higher.CONCLUSION:Children of probands of both sexes had high coefficients of hormonal and metabolic adaptation dependent on the severity of VVD syndrome.

AIM:To evaluate prevalence of metabolic syndrome "X" (MS) components in the families of probands and their wives regarding the presence of hyperinsulinemia and in probands' children of both sexes regarding their having vegetovascular dystonia. MATERIAL AND METHODS:92 families were selected by the proband who survived acute myocardial infarction (MI) at the age under 50: 92 probands (mean age 47 +/- 1.1 years), 57 probands' wives (mean age 47 +/- 0.7 years), 20 sons (mean age 18.3 +/- 0.8 years), 24 daughters (mean age 19.1 +/- 1.0 years). Two groups were formed: group 1 of 48 probands and 25 wives (the presence of hyperinsulinemia in the proband); group 2 of 44 probands and 32 their wives (controls with normal insulin levels). Anthropometric, arterial pressure and lipid-hormonal measurements were made by standard techniques. Nutrition was studied by random reproduction of 24-h diet. RESULTS:More factors of risk to develop atherosclerosis and MS"X" components in probands and their wives were found in group 1. More frequent in the parents were the following MS components: hypoalphacholesterolemia, overweight, arterial hypertension, hyperapolipoprotein-B-emia. Vegetovascular asthenia in the probands' children predisposed to cardiovascular diseases is closely linked with the presence of hypoalphacholesterolemia, hypertriglyceridemia, overweight and arterial hypertension. CONCLUSION:MS "X" for probands and their wives is a "malignant" risk factor for cardiovascular diseases; in the presence of IHD in father, vegetovascular asthenia in children is a risk factor of cardiovascular disease.

Blood lipid composition was studied in 507 selkups, native population of the Tyumen region (199 males and 308 females), 245 slavs living in the North for more than 5 years (97 males and 148 females), 189 first generation metises born in mixed marriages (68 males and 121 females). Three age groups were analyzed: 10-19 (group 1), 20-39 (group 2), 40-59 (group 3). Male metises from groups 1, 2 and 3 had the highest levels of HDLP cholesterol, the lowest of apoB and atherogenic index. Group 2 metises were in the intermediate position between slavs and selkups by concentrations of total and LDLP cholesterol and triglycerides. Group 3 metis males had the lowest levels of triglycerides and intermediate levels of total and LDLP cholesterol. Group 1 and 2 metis females had the highest levels of LDLP, the lowest of apoB and low atherogenic index. In group 3, levels of total cholesterol, LDLP cholesterol, apoB and atherogenic index were as high as in non-aboriginal slavonic population.

Blood lipid composition was studied in 507 Selkups, native population of Tyumen Province (199 males and 308 females), 245 Slavs living in the north for more than 5 years (97 males and 148 females), 189 first generation métis born in mixed marriages (68 males and 121 females). Three age groups were analyzed: 10-19 (group 1), 20-39 (group 2), 40-59 (group 3). Male métis from groups 1, 2 and 3 had the highest levels of HDLP cholesterol, the lowest of apoB and atherogenic index. Group 2 métis were in the intermediate position between Slavs and Selkups by concentrations of total and LDLP cholesterol and triglycerides. Group 3 métis males had the lowest levels of triglycerides and intermediate levels of total and LDLP cholesterol. Group 1 and 2 métis females had the highest levels of LDLP, the lowest of apoB and low atherogenic index. In group 3, levels of total cholesterol, LDLP cholesterol, apoB and atherogenic index were as high as in non-aboriginal Slavonic population.

The purpose of this study was to analyze the relationships between brain hemisphere predominance and disturbance of lipid metabolism in atherosclerosis in different ethnic groups. Three groups of subjects were examined: 52 healthy Selkups (the isolated ethnic population of the Far North), 50 healthy Russian men, living in Novosibirsk, and 78 Russian men, living in Novosibirsk, who had myocardial infarction before the age of 50. Blood cholesterol, low density lypoprotein (LDL) and high density lypoprotein (HDL) levels of the subjects with different brain functional asymmetry were compared. The lack of either hemisphere predominance is the most common among the Selkups. The population of Selkups as a whole showed low concentrations of cholesterol and LDL in comparison with both Russian groups. For all examined groups the pattern of lipid metabolism has been worsened for the subjects showing the left hemisphere predominance. The changes of lipid metabolism indices in subjects with the dominant left hemisphere is discussed.

Altogether 226 male probands who suffered large-focal or transmural myocardial infarction (MI) before reaching 50 years were examined in Novosibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 probands were Kirghizs and 71 were Russians. The probands were examined within a period of 1 to 3 years after MI. The lipid and lipoprotein plasma content was determined by standardized methods on a Tekhnikon AAP autoanalyzer. The content of thyroid hormones, insulin and cortisol was measured by means of RIA-kits and that of apolipoprotein B (ApoB) by radial immunodiffusion. It turned out that the patients from Novosibirsk demonstrated the highest content of cholesterol, low density lipoprotein cholesterol, the highest index of atherogenicity, the highest concentration of ApoB, and hyperinsulinemia. In the probands of both nationalities from Bishkek, the lipid spectrum did not differ substantially from the populational norm, the content of ApoB in the Russian probands was slightly lower than in those from Novosibirsk whereas in Kirghizs, the least content of thyroxin was recorded.

Altogether 226 male probands who suffered large-focal or transmural myocardial infarction (MI) before reaching 50 years were examined in Novosibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 probands were Kirghizs and 71 were Russians. The probands were examined within a period of 1 to 3 years after MI. The lipid and lipoprotein plasma content was determined by standardized methods on a Teknikon AAP autoanalyzer. The content of thyroid hormones, insulin and cortisol was measured by means of RIA-kits and that of apolipoprotein B (ApoB) by radial immunodiffusion. It turned out that the patients from Novosibirsk demonstrated the highest content of cholesterol, low density lipoprotein cholesterol, the highest index of atherogenicity, the highest concentration of ApoB, and hyperinsulineamia. In the probands of both nationalities from Bishkek, the lipid spectrum did not differ substantially from the populational norm, the content of ApoB in the Russian probands was slightly lower than in those from Novosibirsk whereas in Kirghizs, the least content of thyroxin was recorded.

Seventy-eight men (mean age, 47.0 ± 1.1 years) who had suffered from myocardial infarction were examined. Blood cholesterol, lipoproteins, triglycerides, insulin and cortisol concentrations were compared in patients with left hemishpere or right hemisphere cerebral dominance. Patients with left hemisphere dominance had more serious disease and much higher levels of blood cholesterol and lipoproteins. Patients with right hemisphere dominance had the highest levels of blood cortisol and insulin. The brain's functional asymmetry may be one of the risk factors for coronary atherosclerosis in subjects under the age of 50 years.