independent groups of patients.Mir-224_1 has been described upregulated in hepato-cellular carcinomas.Moreover, deregulation of miR-217 has been reported in pancreatic cancers.Mir-23a inhibits both the development of B cells and the production of IL-6.Interestingly, in our study mir-122 is slightly up-regulated in NRs compared to SVRs.The levels of expression of miRNAs involved in tumoral processes were higher in the liver of NRs than in SVRs and RRs.Conclusion: NRs and SVRs present different miRNAs hepatic expression, before treatment.In particular, mir-99a, mir-181a-2*, mir-23a and mir-217 were significantly deregulated in NRs compared to SVRs.Thus, treatment response could be predicted with a molecular miRNAs signature.