Laser Doppler measurements of skeletal muscle blood flow were performed in 12 patients with neuromuscular disorders and 6 controls. The mean resting blood flows and postocclusive reactive hyperemias were similar for the patients with neuropathic disorders and for controls. The patients with myopathic disorders had higher resting muscle blood flows and reactive hyperemias. Correlation of blood flow results and muscle biopsy characteristics suggested that muscle type grouping was not associated with a change in skeletal muscle blood flow, whereas muscle fiber degeneration was associated with an increased blood flow.

We have demonstrated the feasibility of using laser doppler spectroscopy to map regional blood flow distribution on the surface of the cerebral cortex. Rhesus monkeys underwent craniotomy, with replacement of part of the calvarium by a transparent plastic dome. A stroke was produced on one side by ligation of the middle cerebral artery. A flow index was computed from a weighted bandwidth of the doppler spectrum of helium-neon laser light scattered from the surface of the cortex, the doppler shift being due to scattering from moving blood cells in the microcirculation. By measuring the doppler flow index at a grid of points over the surface, the region of the stroke was easily delineated, and its progression with time observed. The method provides a rapid measurement with a spatial resolution of about 1 mm.

ARTICLESMeasurement of renal cortical and medullary blood flow by laser-Doppler spectroscopy in the ratM. D. Stern, P. D. Bowen, R. Parma, R. W. Osgood, R. L. Bowman, and J. H. SteinM. D. Stern, P. D. Bowen, R. Parma, R. W. Osgood, R. L. Bowman, and J. H. SteinPublished Online:01 Jan 1979https://doi.org/10.1152/ajprenal.1979.236.1.F80MoreFiguresReferencesRelatedInformationPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformationSee PDF Cited ByRedox regulation of hemodynamics response to diadenosine tetraphosphate an agonist of P2 receptors and renal function in diet‐induced hypercholesterolemic rats10 June 2021 | Physiological Reports, Vol. 9, No. 11Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes: Basic Concepts22 January 2021Thick Ascending Limb Sodium Transport in the Pathogenesis of HypertensionAgustin Gonzalez-Vicente, Fara Saez, Casandra M. Monzon, Jessica Asirwatham, and Jeffrey L. Garvin24 October 2018 | Physiological Reviews, Vol. 99, No. 1Modeling Glucose Metabolism in the Kidney1 July 2016 | Bulletin of Mathematical Biology, Vol. 78, No. 6Renal Autoregulation in Health and DiseaseMattias Carlström, Christopher S. Wilcox, and William J. Arendshorst1 April 2015 | Physiological Reviews, Vol. 95, No. 2Renal Medullary Circulation1 January 2012Autoregulation of renal medullary blood flow in rabbitsGabriela A. Eppel, Göran Bergström, Warwick P. Anderson, and Roger G. Evans1 January 2003 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 284, No. 1Importance of the renal medullary circulation in the control of sodium excretion and blood pressureDavid L. Mattson1 January 2003 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 284, No. 1 More from this issue > Volume 236Issue 1January 1979Pages F80-F87 Copyright & PermissionsCopyright © 1979 the American Physiological Societyhttps://doi.org/10.1152/ajprenal.1979.236.1.F80PubMed434156History Published online 1 January 1979 Published in print 1 January 1979 Metrics Downloaded 36 times 122 CITATIONS 122 Total citations 0 Recent citations n/a Field Citation Ratio 7.82 Relative Citation Ratio publications60supporting1mentioning43contrasting0Smart Citations601430Citing PublicationsSupportingMentioningContrastingView CitationsSee how this article has been cited at scite.aiscite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.