The influence of the developmental process of individuation, family conflict and cohesion, and ethnicity on adolescent alcohol use was examined in a 3-year longitudinal study. Participants included non-Hispanic White, Mexican American, and African American adolescents (n = 6,522) from 6th, 7th, and 8th grades. They were surveyed annually for 3 years. Depending on which aspect of individuation was measured, hierarchical linear modeling indicated that changes in adolescent individuation were related to either increases or decreases in alcohol use over the 3-year period. Separation and family conflict were related to increases in alcohol use, and intergenerational individuation and family cohesion were related to decreases in alcohol use. White and Mexican American adolescents had a faster rate of increase in alcohol use than did African American youth. Separation and family process similarly influenced adolescent alcohol use from different ethnic groups. Implications for prevention and intervention programs are discussed.

Objective: A structural equation modeling approach is used to assess adolescent alcohol use as a function of two measures of individuation in the context of other family and peer psychosocial factors for adolescents in three ethnic groups. The separation measure captures aspects of individuation related to detachment or rebelliousness. Intergenerational individuation measures increasing self-reliance and control with maintenance of supportive family bonds. Method: A sample of 1,200 sixth through eighth grade black, Mexican-American and non-Hispanic white adolescents participated. A structural equation model describing adolescent alcohol use as a function of two measures of individuation, family conflict, communication with mother, stress and peer use of alcohol was tested and compared for the three ethnic groups. Results: Significant direct and indirect paths to adolescent alcohol use were indicated for individuation measures and family use, peer use and stress variables. The proposed model fit for each of the groups, although the way in which separation related to stress was different in the black group. Conclusions: The findings support the role of individuation as a contributing factor in adolescent alcohol use for each ethnic group. They indicate the importance of family and parent-adolescent relationships in adolescent alcohol use and suggest directions for both family-based and school-based preventive interventions.

OBJECTIVE This study evaluates a developmental psychosocial model of adolescent drinking. Specifically, the role of two aspects of adolescent individuation-separation and intergenerational individuation-is examined within the context of family dynamics, stress and peer associations. These measures parallel an ongoing debate regarding the nature of individuation. The separation measure captures aspects of individuation related to detachment or rebelliousness. Intergenerational individuation measures increasing self-reliance and control with maintenance of supportive family bonds. METHOD A structural equation model describing adolescent alcohol use as a function of two measures of individuation, family conflict, communication with mother, stress and peer use of alcohol was tested in two independent samples. The first included 6th- through 12th-grade adolescents and the second was composed of 6th- through 8th-grade students. RESULTS In both studies, significant direct and indirect paths were found from individuation measures and family, peer use and stress constructs to adolescent alcohol use. Separation had a stronger relationship to alcohol use than did intergenerational individuation and was associated with higher levels of stress and alcohol use by peers. CONCLUSIONS The findings support the role of individuation as a contributing factor in adolescent alcohol use. They indicate the importance of family and parent-adolescent relationships in adolescent alcohol use and suggest directions for both family-based and school-based preventive interventions.

This study of children in grades five and six assessed the relationship between social and stress/coping motives and students' intentions to drink in junior high school. Whereas the two motives were not seen as separate by fifth graders, they were differentiated by sixth graders, for whom they were associated--social motives more strongly than stress/coping motives--with intentions to use alcohol. Implications for the design and timing of prevention programs are considered.

OBJECTIVETo examine the relationship among children's perceptions of peer and parental attitudes toward alcohol use, fifth graders' attitudes toward alcohol use and intentions to use alcohol in junior high school, and alcohol use of these same children as seventh graders.METHODSSubjects completed questionnaires as fifth graders that assessed their perception of parents' and peers' attitudes toward alcohol use, children's attitudes toward alcohol use, and intentions to use alcohol in junior high school. They completed a survey in the seventh grade that assessed alcohol use.RESULTSPath analyses indicated that perceived peer and parental attitudes were directly related to children's fifth-grade attitudes toward alcohol use. Attitudes, in tum, were related to fifth-grade intentions, which were related to seventh-grade alcohol use. Peer and parental attitudes, and children's attitudes as fifth graders, were not directly related to later alcohol use.CONCLUSIONSPeer and parental attitudes toward alcohol use among fifth graders exert an indirect, rather than direct, influence on later alcohol use. Similarly, attitudes of fifth graders influence later alcohol use through their influence on intentions to use alcohol. Prevention programs should be targeted toward younger children prior to initiation of alcohol use and should address both peer and parental influences on attitudes and intentions to use alcohol.

OBJECTIVE:The relationship between intentions to use alcohol and risk factors was examined among fifth and sixth graders.METHOD:Subjects completed a questionnaire that assessed intentions to use alcohol and eight risk factors. Risk factors included peer and parental use and attitudes toward use, sensation seeking, tolerance of deviance, rejection of parental authority, and family cohesion.RESULTS:Multivariate analyses showed that the risk factors were able to discriminate between those who intended to use alcohol and those who did not. Family factors showed stronger relationships to intentions among fifth graders, and peer factors were more strongly related to intentions among sixth graders.CONCLUSIONS:Risk factors can be used to target preadolescents who may be at risk for early alcohol use, and programs that attempt to prevent early initiation of alcohol use among adolescents can be designed.

This cross-sectional study examined relationships among predictors of breast self-examination (BSE) derived from the Health Belief Model and behavioral self-regulation theory. Subjects were 427 gynecology outpatients. Although 64% indicated that they had practiced BSE at least once during the past year, only 27% indicated they practiced BSE monthly. The majority of the subjects knew about most of the recommended BSE steps. The most frequently endorsed reasons for completing BSE were early detection, recommendation from a doctor, and peace of mind. The most frequently endorsed barrier was forgetting/being too busy. Multivariate analysis showed that several psychological variables--including reasons for doing BSE, self-efficacy, and barriers to doing BSE--were related to frequency of BSE. Overall, the variables in this model accounted for about 37% of the variance in BSE frequency.

Objectives Curcumin (Cur) is a natural polyphenol isolated from turmeric and has potent anti-inflammatory and antioxidant activities. This study aimed to explore the effects and possible mechanisms of curcumin on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in cultured rat astrocyte primary cells. Methods After screening for effective doses, the cultured rat astrocyte primary cells were divided into three groups: control, OGD/R, and OGD/R + curcumin (10 μM, 20 μM, and 40 μM). Cell viability was detected using CCK8 assays. The level of malondialdehyde and superoxide dismutase activity was determined using commercial kits. The endothelial nitric oxide synthase and adenosine triphosphate concentrations were determined by enzyme-linked immunosorbent assay. The mRNA levels of the inflammatory indexes interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1β were evaluated by quantitative reverse-transcription polymerase chain reaction. Annexin V-fluorescein isothiocyanate/propidium iodide was used to detect apoptosis. JC-1 was used to assess the mitochondrial membrane potential. The protein expression of apoptosis-related proteins (B-cell lymphoma-2 (Bcl-2), BCL-2-associated X (Bax), and cleaved caspase 3), mitochondria-related proteins (dynamin-related protein 1 (DRP1), phosphorylated DRP1 (p-DRP1), and mitofusin 2), and essential proteins of the extracellular signal-regulated kinase (ERK) signaling pathway (ERK1/2, p-ERK1/2) were analyzed by western blot. Results Our data indicated that curcumin reversed OGD/R-induced cell viability loss, oxidative stress, inflammatory cytokine production, and cell apoptosis in a dose-dependent manner. Furthermore, curcumin attenuated OGD/R-induced mitochondrial dysfunction and ERK1/2 phosphorylation in a dose-dependent manner. Conclusions Curcumin protected against OGD/R-induced injury in rat astrocyte primary cells through improving mitochondrial function and regulating the ERK signaling pathway.

This study examined the relationship between risk factors and initiation of alcohol use over a 15-month period among a cohort of 7th graders who were abstainers at the time of initial testing. The relationship between risk factors and alcohol use was examined using a discriminant function analysis. At the univariate level, rejection of parental authority, deviant behavior, and sensation seeking were statistically significant. The discriminant function retained only three of the risk factors: rejection of parental authority, deviant behavior, and religious commitment. Implications for school-based prevention programs are discussed, particularly the need to target primary prevention programs based upon adolescents' risk.

Two preventive intervention programs on alcohol and other substance use were devised for classrooms of junior and senior high school students. One program focused on resistance to social influence, and the other on attitude change and decision making. Youngsters undergoing these interventions were compared with controls who had no intervention on both alcohol usage measures and nonusage psychosocial indices at a pre-intervention baseline, at one-year post-intervention for tenth graders, and at two-year post-intervention for seventh graders. No difference in outcome between the two interventions was found for tenth graders, but one-year post-intervention tenth graders who had either of the interventions used less alcohol than controls. Nonusage measures were not affected. Seventh graders showed no usage effects of interventions two years post-intervention, but the nonusage measures suggested more prosocial behavior. Also among seventh graders, those with a high score on peer or parent alcohol use modeling responded better to the social resistance intervention, while those with a low score responded better to the attitudinal intervention.

Clinical psychology offers a unique and often complementary approach to assessment and treatment of anxiety and depression. Current practices are examined for their scientific validity and clinical utility.

Alcohol use increases among adults in response to marital disruption and divorce, but data that are available regarding adolescent alcohol use are inconsistent in the light of whether or not families are intact. To explore this question we obtained measures of frequency and quantity of alcohol use from 2595 junior and senior high school students, together with information about family intactness and parental alcohol use. Adolescents in single and stepparent families reported more alcohol use than adolescents from intact families, for both frequency and quantity of use. This was the case for boys and for girls, as well as for junior high school and for senior high school students. Parents in nonintact families also were reported to be using more alcohol than parents in intact families. Adolescent alcohol use was significantly correlated with parental alcohol use. After adjusting adolescent alcohol use for parental alcohol use as a covariate, the finding of greater alcohol use by adolescents in non-intact families remained.

The correlations between self-reported alcohol use by adolescents and peer and parental alcohol use, tolerance of deviance, emotional maladjustment and self-derogation were studied in two independent samples--172 seventh-grade boys, 221 seventh-grade girls, 131 tenth-grade boys and 164 tenth-grade girls in Sample 1, and 166 seventh-grade boys, 149 seventh-grade girls, 120 tenth-grade boys and 129 tenth-grade girls in Sample 2. Regression analyses were performed to identify the relative contribution of each correlate in a prediction formula for alcohol use at the two grade levels and to determine whether the predictors differed at the two grade levels. The results were cross-validated in the two samples and showed that the predictors were similar at the two grade levels, despite the much greater alcohol use by tenth-graders. The major predictors for both grade levels and for both boys and girls were peer and parental alcohol use. Tolerance of deviance contributed to a much lesser degree and emotional maladjustment did not contribute to the prediction equations.