Paul P. Ehrlich | AMiner学者主页

14,5-Disubstituted Cis-Pyrrolidinones As Inhibitors of Type Ii 17 Beta-Hydroxysteroid Dehydrogenase. Part 3. Identification of Lead Candidate

Jill Wood,Cedo M. Bagi,Christiana Akuche, Antonietta Bacchlocchi,Jeremy Baryza,Marie-Luise Blue,Catherine Brennan,Ann-Marie Campbell,Soongyu Choi,James H. Cook,Patricia Conrad,Brian R. Dixon,

A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17beta-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.

2006BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2006）引用：33

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24,5-Disubstituted Cis-Pyrrolidinones As Inhibitors of Type Ii 17 Beta-Hydroxysteroid Dehydrogenase. Part 2. Sar

D Gunn,C Akuche,J Baryza,ML Blue,C Brennan,AM Campbell,SY Choi,J Cook,P Conrad,B Dixon,J Dumas,P Ehrlich,

4,5-Disubstituted cis-pyrrolidinones were investigated as inhibitors of type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Early structure-activity relationship patterns for this class of compounds are discussed.

2005BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2005）引用：32

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3HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION

Mark W Holladay,Melwyn A Abreo,David E Gunn,Nanhorng Lin,David S Garvey,Keith B Ryther,Suzanne A Lebold,Richard L Elliott, H E Yun, James T Wasiak,Hao Bai,Michael J Dart,

2004引用：37

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4DI-SUBSTITUTED AMINOMETHYL CHROMAN DERIVATIVE BETA-3 ADRENORECEPTOR AGONISTS

Gaetan H Ladouceur,William H Bullock,Steven Magnuson,Stephen J Oconnor,Roger A Smith,Quanrong Shen, Quingjie Liu, S U Ning,Emil Velthuisen,Annmarie Campbell,Paul P Ehrlich

2003引用：28

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517-BETA-HYDROXYSTEROID DEHYDROGENASE-II INHIBITORS

Jill E Wood,Jeremy L Baryza,Catherine Brennan,Soongyu Choi, James H Cook,Brian R Dixon,Paul P Ehrlich,David E Gunn,Ian Mcalexander,Peiying Liu,Derek B Lowe,Aniko Redman,

2003引用：23

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63-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS

Mark W Holladay,Stephen P Arneric,Hao Bai,Michael J Dart,Nanhorng Lin,John K Lynch,Yat Sun Or,Keith B Ryther,James P Sullivan,James T Wasicak,Paul P Ehrlich

2002引用：41

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73-phenylpyrrolidine alpha-1 adrenergic compounds

Paul P Ehrlich,Jeffrey W Ralston,Jerome F Daanen,Michael D Meyer

2000引用：26

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8Process for preparing chiral tetracyclic dopaminergic compounds

Paul P Ehrlich,Michael R Michaelides,Maureen A Mclaughlin, Chinung Hsaio

1997引用：24

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9Use of the Thiomethyl Group for Activation in the Synthesis of 8-Hydroxy-1-(spiro-1′-indan)benzazepines

PP Ehrlich,JR Campbell

The utilization of the thiomethyl group to activate an aromatic ring system for closure to form the corresponding conformationally restrained 8-methoxy-7-(methylthio)-3-methyl-1-(spiro-1′-indan)2,3,4,5-tetrahydro-1H-3-benzazepine is described. Subsequent removal of the thiomethyl group with Raney nickel followed by electrophilic substitution allows for the synthesis of other benzazepines that have electron withdrawing groups that normally would be inaccessible.

1996TETRAHEDRON LETTERS（1996）引用：6

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