ABSTRACT The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunocompromised patient with tuberculosis who was initially treated with TMP-SMX without antituberculous drugs and defervesced on this treatment. An isolate of M. tuberculosis from this patient was found to be sensitive to TMP-SMX. We examined how frequently M. tuberculosis is sensitive to TMP-SMX. Isolates were tested for susceptibility to TMP-SMX on supplemented Middlebrook 7H10 plates. We found that 43 of 44 (98%) isolates of M. tuberculosis were susceptible to the combination of ≤1 μg/ml of TMP and 19 μg/ml of SMX (≤1/19 μg/ml). Thus, the vast majority of our M. tuberculosis isolates were susceptible to TMP-SMX at an MIC similar to that for Mycobacterium kansasii, Mycobacterium marinum, and sensitive rapidly growing mycobacteria, organisms successfully treated with TMP-SMX as part of the treatment regimen. It is possible that TMP-SMX may be useful in treating patients with multiple-drug-resistant and extended drug-resistant tuberculosis. We feel that a clinical trial looking at the effectiveness of TMP-SMX as an antituberculous drug is worthwhile.

No AccessJournal of UrologySOCIETY OF UROLOGIC ONCOLOGY: Case Reports1 Jun 2000TUBERCULOSIS OF THE PENIS AFTER INTRAVESICAL BACILLUS CALMETTE-GUERIN TREATMENT JERILYN M. LATINI, DAVID S. WANG, PIERRE FORGACS, and WILLIAM BIHRLE JERILYN M. LATINIJERILYN M. LATINI More articles by this author , DAVID S. WANGDAVID S. WANG More articles by this author , PIERRE FORGACSPIERRE FORGACS More articles by this author , and WILLIAM BIHRLEWILLIAM BIHRLE Financial interest and/or other relationship with Schering-Plough. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67569-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "TUBERCULOSIS OF THE PENIS AFTER INTRAVESICAL BACILLUS CALMETTE-GUERIN TREATMENT." The Journal of Urology, 163(6), p. 1870 References 1 : Primary tuberculosis of the glans penis. J Am Acad Dermatol1992; 26: 1002. Google Scholar 2 : Mycobacterium bovis-BCG infection of the glans penis: a complication of intravesical administration of bacillus Calmette-Guérin. Br J Dermatol1995; 132: 309. Google Scholar 3 : Penile edema and meatal ulceration after intravesical instillation with bacillus Calmette-Guérin. Urology1996; 47: 932. Google Scholar From the Department of Urology and Section of Infectious Diseases, Lahey Clinic Medical Center, Burlington, Massachusetts© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMATLAGA B, VEYS J, THACKER C and ASSIMOS D (2018) PROSTATE ABSCESS FOLLOWING INTRAVESICAL BACILLUS CALMETTE-GUERIN TREATMENTJournal of Urology, VOL. 167, NO. 1, (251-251), Online publication date: 1-Jan-2002. Volume 163Issue 6June 2000Page: 1870 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.KeywordstuberculosispenisMycobacterium bovisMetrics Author Information JERILYN M. LATINI More articles by this author DAVID S. WANG More articles by this author PIERRE FORGACS More articles by this author WILLIAM BIHRLE Financial interest and/or other relationship with Schering-Plough. More articles by this author Expand All Advertisement PDF downloadLoading ...

A case of acute human immunodeficiency virus (HIV) infection manifested by a rapidly fulminating, necrotizing, demyelinating encephalopathy that led to brain death in 5 days is reported. Autopsy demonstrated predominant white matter lesions, acute neuronal damage, and scanty cellular response. Cultures of cerebrospinal fluid were positive for HIV, suggesting an acute infection.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloids from Fumaria capreolata and Fumaria bellaP. Forgacs, J. Provost, A. Touche, and A. JehannoCite this: J. Nat. Prod. 1986, 49, 1, 178–179Publication Date (Print):January 1, 1986Publication History Published online1 July 2004Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/np50043a036https://doi.org/10.1021/np50043a036research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAucubin from Sutera dissectaP. Forgacs, J. Provost, and A. JehannoCite this: J. Nat. Prod. 1986, 49, 2, 367Publication Date (Print):March 1, 1986Publication History Published online1 July 2004Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/np50044a043https://doi.org/10.1021/np50044a043research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Erichsonine is a new indole alkaloid isolated from the stem bark of Strychnos erichsonii. Its structure has been established by spectral means and confirmed by X-ray crystallographic analysis. This is the first report of a vobasine-type alkaloid from the Loganiaceae.

From the trunk bark of Odyendea gabonensis (Pierre) Engl. Simaroubaceae, two-new quassinoids have been isolated : Odyendane and Odyendene. Their structures were established from spectral data and X-Ray diffraction analysis.

From the trunk bark of Odyendea gabonensis (Pierre) Engl. Simaroubaceae, two-new quassinoids have been isolated : Odyendane and Odyendene. Their structures were established from spectral data and X-Ray diffraction analysis.

AbstractDie Ver‐ bindungen (Ia) und (Ib) sind als erste bekannte Glieder einer neuen Klasse, der 1‐(2′‐Aminopyrimidin‐4‐ylHB‐carbolin‐Alkaloide, anzusehen.

From the trunk bark of Odyendea gabonensis six indole alkaloids have been isolated: Canthin-6-one (I); 5-Methoxy-canthin-6-one (II); 4,5-Dimethoxycanthin-6-one (III); 8-Hydroxy-canthin-6-one (IV); 1-Hydroxy-methyl-beta-carboline (V); and 1-Carboxamide-beta-carboline (VI). This is the first report of these products from this plant.

Two new alkaloids, which we have named annomontine (1) and methoxyannomontine (2), have been isolated from the trunk- and root-barks of Annona montana Macf. (Annonaceae). Their structures have been deduced by spectral analysis and confirmed by an X-ray structure determination of (2). They are the first members of the new class of 1-(2′-aminopyrimidin-4-yl)-β-carboline alkaloids.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloids of Annonaceae. XXXV. Alkaloids of Desmos TiebaghiensisMichel Leboeuf, André Caré, Mahgoub El Tohami, Jacques Pusset, Pierre Forgacs, and Jean ProvostCite this: J. Nat. Prod. 1982, 45, 5, 617–623Publication Date (Print):September 1, 1982Publication History Published online1 July 2004Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/np50023a017https://doi.org/10.1021/np50023a017research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

AbstractAusgehend von dem löa‐Hydroxy‐l 8,20R‐oxidopregnen (Ia) wird über die angegebenen Stufen‐(Übergang (Id)‐(Ie) erfolgt unter Inversion an C‐16) das 16oz‐Amin (Ig) aufgebaut, das in Gegenwart von Ac2O/BF3 ′ Et2O unter Spaltung des Oxidringes in das Diacetat (II) übergeht.