Introduction The epidemiology of upper gastrointestinal (UGI) cancer is rapidly changing. Current guidelines for red flag symptoms for UGI cancer were drawn up using evidence from a past age. With the exception of dysphagia, many of the symptoms are non-specific for UGI cancer in particular dyspepsia, particularly with the rapidly declining prevalence of H. pylori and its associated gastric cancers. Aims To determine the value of individual UGI cancer red flag symptoms alone or in combination in predicting the presence of UGI and non-UGI cancers. Method Our routine practice is to investigate all patients referred under the urgent suspected cancer (USC) pathway with an oesophagogastroduodenoscopy (OGD) and a computed tomography (CT) scan if over 50 years of age and symptoms are not purely oesophageal. A retrospective case review between October 2013 to March 2014 of all referrals on the USC pathway to our district general hospital with a case review of all the UGI cancers detected by our service over a one year period (October 2013–2014). Clinical follow-up after referral was a minimum of 11 months. Results 391 patients (20–96 age range) were seen under the USC pathway between October 2013–March 2014. In total 372 and 177 patients were investigated with an OGD and a CT scan respectively; 289 and 161 respectively were patients over the age of 50. 19 cancers were detected giving a detection rate of 4.75%. Of those only nine were UGI cancers (three gastric, six oesophageal). Other cancers found included three colorectal, one pancreatic, three lung, one cholangiocarcinoma, one ovarian and one peritoneal. The table shows the symptoms distribution for both UGI and non-UGI cancers. Isolated red flag symptoms had poor predictive power. Weight loss and dysphagia in combination with other symptoms had the best predictive value. There was a similar number of UGI cancers (23) and non UGI cancers (19). Analysis of all UGI cancers n = 47 over the course of one year not necessarily presenting through the USC route (October 2013–2014) revealed that isolated dyspepsia was found in only two of 47 patients compared to iron deficiency anaemia, weight loss and dysphagia which were the sole presenting symptoms in seven, four and three patients respectively, reinforcing the findings from the USC referrals. Conclusion In modern times, isolated UGI cancer red flag symptoms particularly dyspepsia are poorly predictive of UGI cancer, and equally well predict the presence of cancer outside the UGI tract. CT scanning should be a routine part of evaluation of UGI cancer referrals in the over 50’s. Disclosure of interest None Declared.

Introduction Central venous thrombosis (CVT) associated with a central venous catheter (CVC) has an incidence of 0.027 episodes per catheter per year in parenteral nutrition use.1 Loss of venous access may occur, with loss of two or more central veins being an indication for intestinal transplantation. We describe a 4-year single centre experience of the interventional management of CVT associated with CVCs. Methods Patients who underwent interventional management of their CVTs were identified and clinical records assessed. Upper limb catheter position was recorded as described previously.2 Results Nine (eight females) patients underwent 10 interventions. Mean age: 48.8 years (range 22–67). Intestinal failure aetiology: functional (3), Crohn's disease (3), mesenteric infarction (2) and FAP/desmoid disease.1 Six patients were smokers and two were on anti-coagulant therapy. Seven patients were on intravenous nutrition and 2 on parenteral fluids only. Mean duration of parenteral therapy was 4.4 years and the catheters were in situ for 19.2 months (mean, range 1 month–8 years). Interventions are summarised in Abstract 062. Four out of nine patients were noted to have a proximal catheter tip position at the time of thrombosis. Two patients developed complications of bleeding after thrombolysis (one at venepuncture site and the other developed occult GI bleeding) but required no therapy. 30-day mortality was 1 patient, unrelated to thrombosis. Abstract PTH-062 Intervention Number treated Patency (%) Thrombolysis No stent No venoplasty 4 50 Thrombolysis Stent No venoplasty 4 75 Thrombolysis No stent Venoplasty 1 100 Thrombolysis Stent Venoplasty 1 100 Conclusion We show that local thrombolysis, venoplasty and venous stenting are safe and when used in combination re-establish venous patency in 70%.

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Introduction Central venous thrombosis (CVT) associated with a central venous catheter (CVC) has an incidence of 0.027 episodes per catheter per year in parenteral nutrition use.1 Loss of venous access may occur, with loss of two or more central veins being an indication for intestinal transplantation. We describe a 4-year single centre experience of the interventional management of CVT associated with CVCs. Methods Patients who underwent interventional management of their CVTs were identified and clinical records assessed. Upper limb catheter position was recorded as described previously.2 Results Nine (eight females) patients underwent 10 interventions. Mean age: 48.8 years (range 22–67). Intestinal failure aetiology: functional (3), Crohn9s disease (3), mesenteric infarction (2) and FAP/desmoid disease.1 Six patients were smokers and two were on anti-coagulant therapy. Seven patients were on intravenous nutrition and 2 on parenteral fluids only. Mean duration of parenteral therapy was 4.4 years and the catheters were in situ for 19.2 months (mean, range 1 month–8 years). Interventions are summarised in Abstract 062. Four out of nine patients were noted to have a proximal catheter tip position at the time of thrombosis. Two patients developed complications of bleeding after thrombolysis (one at venepuncture site and the other developed occult GI bleeding) but required no therapy. 30-day mortality was 1 patient, unrelated to thrombosis. Conclusion We show that local thrombolysis, venoplasty and venous stenting are safe and when used in combination re-establish venous patency in 70%.

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.

Historically, Hepatitis E infection has been thought to follow a benign clinical course. We report a case of Acute Hepatitis E infection in a non-pregnant female, resulting in the development of Acute Liver Failure necessitating a liver transplant.