On the cover: A highly simplified species for genome engineering would facilitate rational design of a synthetic plant.Eric Lam and

On the cover: Protein engineering is a rapidly growing field that bridges multiple fields of study.For example, chemistry lends a hand in understanding and modifying enzyme catalysis, and biochemistry and structural biology contribute knowledge and manipulation of protein function and structure.As such, Trends in Chemistry and Trends in Biochemical Sciences have collaborated on Focused and Special Issues, respectively, that highlight advances in chemoenzymatic synthesis and applications of protein engineering.Cover image by Kip Lyall.

On the cover: Cancer is a paradox.It is highly prevalent, but since every tumor is distinct, each case presents as a disease of one.To pigeonhole cancer is to pursue a single answer to "the ultimate question of Life, the Universe, and Everything" from Douglas Adams' fi ctional The Hitchhiker's Guide to the Galaxy.Solid tumors remain particularly intractable to a generalized, one-size-fi t-all approach: systemic therapy is ineffective nearly 70% of the time and 90% of new therapies fail in clinical trials.On pages 1361-1373 of this issue, Budhwani et al. hitchhike over four broad categories -in vitro, in vivo, in silico, and ex vivo -to construct a roadmap for next generation cancer models that improve our chances against yet-unknown oncogenic bypasses.Cover image designed by Dr.

On the cover: The entorhinal cortex (EC) often exhibits the earliest histological alterations in Alzheimer's disease (AD).Recent studies have documented impaired neuronal activity in the EC that precedes neurodegeneration.In this issue of Trends in Neurosciences, Kei Igarashi discusses the emerging hypothesis that memory impairments and spatial navigation defi cits at the initial stage of AD may be caused by EC activity dysfunction, and the potential implications of these fi ndings for mitigating AD progression by protecting the EC.Cover image by Aehyun Shin.

Advisory Editorial Board Silvia Arber Anders Björklund J. Paul Bolam Sarah W. Bottjer Rui M. Costa Ann Marie Craig Barry J. Dickson Chris Q. Doe Craig C. Garner Yukiko Goda Kenneth D. Harris Nancy Ip Meyer Jackson Maria Karayiorgou Robert C. Malenka Mark P. Mattson Freda D. Miller Richard G.M. Morris Maiken Nedergaard Eric Nestler Anna W. Roe Hitoshi Sakano Wolf Singer Greg Stuart Marc Tessier-Lavigne Chris A. Walsh