1. The relationships between the haemodynamic, renal and endocrine changes induced by rapid ventricular pacing were studied in ten chloralose-anaesthetized dogs paced from the right ventricular apex for 60 min at 250 beats/min. 2. Pacing increased mean right atrial and mean pulmonary wedge pressure (P less than 0.05), and decreased cardiac output and mean arterial pressure (P less than 0.05). 3. Coronary sinus atrial natriuretic peptide (ANP) concentrations were approximately fourfold greater than arterial concentrations; both increased markedly during pacing (P less than 0.01). Plasma concentrations of arginine vasopressin and plasma renin activity did not change significantly. 4. Urine flow and free water clearance increased during the latter 30 min of pacing (P less than 0.05). There was no significant change in sodium clearance despite high sustained concentrations of ANP. 5. Without the availability of specific inhibitors of ANP release or action, we are unable to exclude the possibility that ANP may have prevented sodium clearance from otherwise decreasing during rapid ventricular pacing. Nevertheless, the dissociation between elevated ANP concentrations and natriuresis in this study indicates that a rise in ANP concentrations per se is not sufficient to produce a natriuresis.

Conference Abstract| January 01 1988 Atrial Natriuretic Peptide is Secreted Directly into the Left Atrial Cavity K P Walsh; K P Walsh 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar T D M Williams; T D M Williams 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar S R Morris; S R Morris 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar A J Drake-Holland; A J Drake-Holland 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar M I M Noble; M I M Noble 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar E Pitts; E Pitts 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar S L Lightman; S L Lightman 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar R Sutton R Sutton 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, and Dept. of Medicine I, St. George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1988) 74 (s18): 61P–62P. https://doi.org/10.1042/cs074061Pc Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation K P Walsh, T D M Williams, S R Morris, A J Drake-Holland, M I M Noble, E Pitts, S L Lightman, R Sutton; Atrial Natriuretic Peptide is Secreted Directly into the Left Atrial Cavity. Clin Sci (Lond) 1 January 1988; 74 (s18): 61P–62P. doi: https://doi.org/10.1042/cs074061Pc Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1988 The Biochemical Society and the Medical Research Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.

1. To assess the ability of the atria to maintain elevated plasma concentrations of atrial natriuretic peptide (ANP), the temporal changes in plasma ANP concentrations were studied in seven chloralose-anaesthetized dogs during 4 h of sustained rapid cardiac pacing. 2. Heart rate increased from 124 +/- 26 (mean +/- SEM) to 278 +/- 28 beats/min for the 4 h duration of rapid cardiac pacing. Mean pulmonary wedge pressure increased from 3.6 +/- 1.8 to 17.4 +/- 7.1 mmHg at 30 min (P less than 0.01) and mean right atrial pressure rose from -1.7 +/- 1.9 to 2.0 +/- 2.8 mmHg at 30 min (P less than 0.01). Both remained constant at these elevated pressures for the entire 240 min of rapid pacing. 3. Arterial ANP concentrations increased in all dogs from 87 +/- 11 to a maximum of 1263 +/- 592 pmol/l at 30 min (P less than 0.01), falling to 411 +/- 42 pmol/l after 60 min and to 146 +/- 70 pmol/l after 240 min of rapid continuous pacing (P less than 0.01 compared with 30 min). Coronary sinus ANP concentrations showed a similar pattern, rising from 241 +/- 79 to a maximum of 1837 +/- 203 pmol/l after 30 min (P less than 0.01). These peak values likewise were not sustained, falling to 962 +/- 198 pmol/l after 60 min and 297 +/- 41 pmol/l after 240 min of rapid pacing (P less than 0.01 compared with 30 min). 4. It is concluded that atria are unable to maintain the peak concentrations of ANP reached after 30 min of rapid pacing despite persistently elevated atrial pressures.

To investigate whether atrial natriuretic peptide (ANP) release during paroxysmal tachycardia is due to increased atrial rate or increased atrial pressure, plasma ANP concentrations were measured during atrial pacing at increasing rates in six alpha-chloralose-anesthetized dogs whose atrial pressures were maintained artificially low by balloon occlusion of the inferior vena cava (IVC). These ANP concentrations were compared with those seen during identical increasing atrial rates in the same dogs without IVC occlusion. During incremental pacing without IVC occlusion, pulmonary wedge pressure (PWP; mean +/- SE) rose progressively from 5.3 +/- 1.6 at 200 to 20.2 +/- 2.3 mmHg at 350 beats/min (P less than 0.01), and right atrial pressure (RAP) rose progressively from 2.5 +/- 0.9 at 200 to 6.7 +/- 2.1 mmHg at 350 beats/min (P less than 0.05). At the same time, arterial and coronary sinus ANP concentrations rose from 116 +/- 55 and 339 +/- 91 to 1,126 +/- 226 and 1,960 +/- 456 pmol/l, respectively (P less than 0.01). In contrast, incremental pacing with IVC occlusion produced no significant increase in PWP and RAP. Arterial and coronary sinus ANP concentrations during IVC occlusion were, respectively, 208 +/- 126 and 388 +/- 159 at 200 and 261 +/- 83 and 345 +/- 80 pmol/l at 350 beats/min (NS). This study demonstrates that the release of ANP during tachycardia is primarily dependent on increased atrial pressure and not atrial rate.

The effects of graded infusions of atrial natriuretic peptide (ANP) on hemodynamics, renal function, plasma renin activity (PRA) and plasma arginine vasopressin (AVP) were investigated in a two part study in 6 volunteers. Three 30-min iv infusions of either saline control or ANP at graded rates of 4, 10 and 40 pmol kg−1 min−1 were given. ANP infusions were associated with a significant increase in sodium clearance from 1.08 ± 0.21 to 2.83 ± 0.50 ml/min, an increase in hematocrit and a net fluid loss. Plasma AVP remained constant during ANP infusions but increased significantly aftewards when plasma ANP concentrations were falling rapidly, and this was accompanied by marked antidiuresis. PRA fell by 23% during the saline control infusions and by 50% during ANP infusions. Following cessation of ANP infusions there was a significant rebound increase in PRA. No changes were observed in blood pressure, heart rate, glomerular filtration rate or renal plasma flow. These results suggest an interaction in man between ANP and the hormones renin and AVP.

Conference Abstract| December 01 1988 Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis T D M Williams; T D M Williams 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar K P Walsh; K P Walsh 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar M I M Noble; M I M Noble 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar A J Drake-Holland; A J Drake-Holland 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar E Pitts; E Pitts 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar S L Lightman; S L Lightman 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar R Sutton R Sutton 1Depts. of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1988) 75 (s19): 31P. https://doi.org/10.1042/cs075031P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation T D M Williams, K P Walsh, M I M Noble, A J Drake-Holland, E Pitts, S L Lightman, R Sutton; Rapid Atrial Pacing in Cardiac Denervated Dogs Causes Sodium Retention and Not Natriuresis. Clin Sci (Lond) 1 December 1988; 75 (s19): 31P. doi: https://doi.org/10.1042/cs075031P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1988 The Biochemical Society and the Medical Research Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.

Conference Abstract| January 01 1988 The Stimulated Release of Atrial Natriuretic Peptide is Unchanged by Cardiac Denervation K P Walsh; K P Walsh 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar T D M Williams; T D M Williams 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar M I M Noble; M I M Noble 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar A J Drake-Holland; A J Drake-Holland 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar C Spiteri; C Spiteri 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar E Pitts; E Pitts 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar S L Lightman; S L Lightman 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar R Sutton R Sutton 1Depts. of Cardiology and Medicine, Charing Cross and Westminster Medical School, Westminster Hospital and Dept. of Medicine I, St George's Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1988) 74 (s18): 62P. https://doi.org/10.1042/cs074062P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation K P Walsh, T D M Williams, M I M Noble, A J Drake-Holland, C Spiteri, E Pitts, S L Lightman, R Sutton; The Stimulated Release of Atrial Natriuretic Peptide is Unchanged by Cardiac Denervation. Clin Sci (Lond) 1 January 1988; 74 (s18): 62P. doi: https://doi.org/10.1042/cs074062P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1988 The Biochemical Society and the Medical Research Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.

The relationships between the hemodynamic, renal, and endocrine changes induced by rapid atrial pacing were studied in seven chloralose-anesthetized greyhounds paced from the right atrial appendage for 60 min at 250 beats/min. Pacing increased mean pulmonary wedge pressure, decreased cardiac output, and decreased mean arterial pressure. Systemic vascular resistance did not change significantly. Coronary sinus atrial natriuretic peptide (ANP) concentrations rose maximally within 5 min of commencing pacing. The corresponding increase in arterial ANP concentrations during this time was only 44% of its maximum value after 30 min of pacing. Plasma concentrations of arginine vasopressin were unchanged. Plasma renin activity decreased during pacing and showed a marked rebound increase at 60 min postpacing. Plasma norepinephrine levels did not change significantly during pacing. Urine flow increased during the latter 30 min of pacing. There was no significant change in sodium clearance despite high sustained concentrations of ANP. The lack of significant natriuretic and systemic vasodilator effects in association with high arterial plasma concentrations of endogenous ANP, in the absence of antagonistic mechanisms, suggests that the natriuretic and vascular effects of ANP may not be its major physiological actions.

Conference Abstract| January 01 1986 Hormonal and Renal effects of Atrial Natriuretic Peptide in Han T.D.M. Williams; T.D.M. Williams 1Departments of Medicine and Cardiology, Charing Cross & Westminster Medical School, Westminster Hospital, LONDON SWIP 2AP Search for other works by this author on: This Site PubMed Google Scholar K.P. Walsh; K.P. Walsh 1Departments of Medicine and Cardiology, Charing Cross & Westminster Medical School, Westminster Hospital, LONDON SWIP 2AP Search for other works by this author on: This Site PubMed Google Scholar E. Pitts; E. Pitts 1Departments of Medicine and Cardiology, Charing Cross & Westminster Medical School, Westminster Hospital, LONDON SWIP 2AP Search for other works by this author on: This Site PubMed Google Scholar R. Sutton; R. Sutton 1Departments of Medicine and Cardiology, Charing Cross & Westminster Medical School, Westminster Hospital, LONDON SWIP 2AP Search for other works by this author on: This Site PubMed Google Scholar S.L. Lightman S.L. Lightman 1Departments of Medicine and Cardiology, Charing Cross & Westminster Medical School, Westminster Hospital, LONDON SWIP 2AP Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1986) 71 (s15): 37P–38P. https://doi.org/10.1042/cs071037Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T.D.M. Williams, K.P. Walsh, E. Pitts, R. Sutton, S.L. Lightman; Hormonal and Renal effects of Atrial Natriuretic Peptide in Han. Clin Sci (Lond) 1 January 1986; 71 (s15): 37P–38P. doi: https://doi.org/10.1042/cs071037Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1986 The Biochemical Society and the Medical Research Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.

Conference Abstract| January 01 1986 Rapid Atrial Pacing Suppresses Renin Secretion and Causes Diuresis in Dogs K P Walsh; K P Walsh 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar T D M Williams; T D M Williams 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar R Canepa-Anson; R Canepa-Anson 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar E Pitts; E Pitts 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar P Roe; P Roe 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar S L Lightman; S L Lightman 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar R Sution R Sution 1Departments of Medicine and Cardiology, Charing Cross and Westminster Medical School, Westminster Hospital, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1986) 71 (s15): 6P. https://doi.org/10.1042/cs071006P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation K P Walsh, T D M Williams, R Canepa-Anson, E Pitts, P Roe, S L Lightman, R Sution; Rapid Atrial Pacing Suppresses Renin Secretion and Causes Diuresis in Dogs. Clin Sci (Lond) 1 January 1986; 71 (s15): 6P. doi: https://doi.org/10.1042/cs071006P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1986 The Biochemical Society and the Medical Research Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.