目的 采用MRI-T2*技术定量分析β-重型地中海贫血(β-TM)心肌、肝脏、胰腺铁沉积,观察其与糖代谢的相关性.方法 回顾性分析109例β-TM患者,其中91例于MR检查前后2周内接受空腹血糖检测,根据检测结果将其分为血糖升高组(n=19)及血糖正常组(n=72),比较组间临床资料及MRI指标差异,分析心肌、肝脏、胰腺R2*值(1/T2*)与血糖代谢指标的相关性.采用Logistics回归分析糖代谢异常的危险因素,绘制心肌、肝脏、胰腺R2*预测血糖升高的受试者工作特征(ROC)曲线,评价其诊断效能.结果 109例β-TM患者心肌T2*值27.72(15.87,31.16)ms,肝脏T2*值1.71(1.34,3.07)ms,胰腺T2*值6.09(3.76,15.02)ms.血糖升高组与血糖正常组间年龄、输血年限、总输入铁量、去铁年限、空腹血糖、胰岛素抵抗指数、心肌R2*及胰腺R2*差异均有统计学意义(P均＜0.05).心肌及胰腺R2*均与空腹血糖呈正相关(r=0.36、0.41,P均＜0.01),肝脏R2*与空腹血糖无明显相关(P=0.76).肝脏R2*、胰腺R2*均为糖代谢异常危险因素(P均＜0.05).心肌及胰腺R2*预测空腹血糖升高的曲线下面积(AUC)均为0.80(P均＜0.01).结论 心肌、胰腺铁沉积与β-TM血糖代谢存在一定相关性;心肌和胰腺R2*预测β-TM血糖升高的诊断效能佳.

Purpose: To evaluate the diagnostic performance of PI-RADS v2, proposed adjustments to PI-RADS v2 (PA PI-RADS v2) and biparametric magnetic resonance imaging (MRI) for prostate cancer detection. Methods: A retrospective cohort of 224 patients with suspected prostate cancer was included from January 2016 to November 2018. All the patients underwent a multi-parametric MR scan before biopsy. Two radiologists independently evaluated the MR examinations using PI-RADS v2, PA PI-RADS v2, and a biparametric MRI protocol, respectively. Receiver operating characteristic (ROC) curves for the three different protocols were drawn. Results: In total, 90 out of 224 cases (40.18%) were pathologically diagnosed as prostate cancer. The area under the ROC curves (AUC) for diagnosing prostate cancers by biparametric MRI, PI-RADS v2, and PA PI-RADS v2 were 0.938, 0.935, and 0.934, respectively. For cancers in the peripheral zone (PZ), the diagnostic sensitivity was 97.1% for PI-RADS v2/PA PI-RADS v2 and 96.2% for biparametric MRI. Moreover, the specificity was 84.0% for biparametric MRI and 58.0% for PI-RADS v2/PA PI-RADS v2. For cancers in the transition zone (TZ), the diagnostic sensitivity was 93.4% for PA PI-RADS v2 and 88.2% for biparametric MRI/PI-RADS v2. Furthermore, the specificity was 95.4% for biparametric MRI/PI-RADS v2 and 78.0% for PA PI-RADS v2. Conclusions: The overall diagnostic performance of the three protocols showed minimal differences. For lesions assessed as being category 3 using the biparametric MRI protocol, PI-RADS v2, or PA PI-RADS v2, it was thought prostate cancer detection could be improved. Attention should be paid to false positive results when PI-RADS v2 or PA PI-RADS v2 are used.

BACKGROUND:Diabetes mellitus affects more than a quarter of patients with thalassemia major (TM) worldwide, and increases the risk for cardiac complications, contributing to significant morbidity. Pancreatic iron overload (IO) and fat infiltration have been correlated with this endocrinal complication in adult TM patients. It has been shown that in adult TM patients, iron accumulation and fat infiltration are found to be heterogeneous in the pancreatic head, body, and tail region. R2* and a fat fraction (FF) generated by gradient-echo imaging can be used as quantitative parameters to assess the iron and fat contents of the pancreas. This study aimed to determine the pattern of pancreatic iron accumulation and fat infiltration in pediatric TM patients with gradient-echo imaging and evaluate the association between pancreatic IO and fat infiltration and glucose disturbances.METHODS:A total of 90 children with TM (10.7±3.1 years) were included. All patients underwent pancreatic magnetic resonance imaging (MRI) using multi-echo gradient-echo sequences. IO was measured by R2* relaxometry in 90 patients, and FF values were measured using iterative decomposition of water and fat with echo asymmetry and the least-squares estimation (IDEAL) method in 40 patients. R2* and FF were assessed in the pancreatic head, body, and tail. The global R2* and global FF values were obtained by averaging the respective values from the pancreatic head, body, and tail. The correlations between global R2*, global FF, and fasting glucose were determined using Spearman's correlation analysis. The Friedman test was used to compare R2* and FF among different pancreatic regions. Receiver operating characteristic (ROC) analysis was used to determine the performance of global R2* and global FF in discriminating impaired fasting glucose from normal fasting glucose patients.RESULTS:The global R2* was positively correlated with the global FF in the pancreas (r=0.895, P<0.001). No significant differences were found in R2* among the 3 regions of the pancreas (χ2=4.050, P=0.132), but significant differences were found in FF among the 3 pancreatic regions (χ2=16.350, P<0.001). Both global pancreatic R2* (r=0.408, P<0.001) and global FF (r=0.523, P=0.001) were positively correlated with fasting glucose. ROC analysis showed that global pancreatic R2* and global FF had an area under the curve of 0.769 and 0.931 (both P<0.001), respectively, in discriminating between impaired and normal glucose function patients.CONCLUSIONS:Pediatric TM patients can have homogeneous iron siderosis and heterogeneous fat infiltration in the pancreas as measured by gradient-echo imaging, both of which are risk factors for diabetes.

目的 观察MR T1rho成像诊断肝硬化的可行性,分析其与Child-Pugh肝功能分级的关系.方法 对42例肝硬化患者和22名健康成年志愿者行肝脏MR T1rho检查,对比T1rho值与Child-Pugh肝功能分级,拟合T1rho值诊断肝硬化的ROC 曲线.结果 Child-Pugh A、B、C级组肝T1rho值分别为(46.32±3.80)ms、(48.08±3.97)ms、(54.43±2.48)ms,均高于健康志愿者(41.45±2.51)ms(P均＜0.01).Child-Pugh A与C级、B与C级T1rho值差异均有统计学意义(P均＜0.01),而A与B级T1rho值差异无统计学意义(P=0.17).Child-Pugh分级与T1rho值呈正相关(r=0.81,P＜0.01),根据肝T1rho值鉴别不同Child-Pugh分级肝硬化的AUC为0.82～0.95(P均＜0.01).结论 MR T1rho成像可用于定量诊断肝硬化,并可初步评价肝硬化患者Child-Pugh肝功能分级.

目的 总结骶尾部藏毛窦的临床特点及MRI影像学特征.方法 回顾性分析5例经病理证实的骶尾部藏毛窦患者的临床资料及其MRI表现.结果 5例病灶均为骶尾部皮下窦道;窦口位于骶5至尾3椎体水平臀间裂皮肤处;窦道行走于骶尾部皮下,向上走形,走形迂曲或形态不规则;窦道管壁较厚,T2加权成像脂肪抑制(T2WI?FS)呈高信号,T1WI呈低信号,管腔无积脓积液时,T2WI?FS及T1WI均呈低信号,管腔内积脓或积液时,T2WI?FS呈高信号,T1WI上呈低信号?稍高信号;窦道周围常出现软组织水肿;病灶易合并感染,窦道管壁及周围软组织增强呈明显强化;病变均未累及骶尾骨及肛管.结论 MRI可准确显示藏毛窦的窦道位置、范围及与周围组织之间的关系,在骶尾部藏毛窦的诊断上具有重要的临床价值.

[目的]MRI-T2*定量评价β-重型地中海贫血(β-TM)患者心肌、肝脏、胰腺铁沉积程度,探讨心肌铁沉积与肝脏、胰腺铁沉积的关系.[方法]回顾性分析2014年5月至2016年1月期间在我院行心脏、肝脏、胰腺MRI-T2*检查的109例β-TM患者的临床、实验室和MRI资料,采用Spearman相关性分析探讨心肌T2*值与肝脏、胰腺T2*值之间关系.将心肌、肝脏铁沉积的患者纳入A组(n=32),仅肝脏铁沉积、而心肌铁含量正常的患者纳入B组(n=69),将心肌、胰腺铁沉积的患者纳入C组(n=34),仅胰腺铁沉积、而心肌铁含量正常的患者纳入D组(n=58),采用两独立样本比较的Wilcoxon秩和检验比较A组与B组肝脏T2*、C组与D组胰腺T2*值的差异.绘制用肝脏、胰腺R2*(1/T2*)预测心肌铁沉积的ROC曲线.[结果]109例β-TM患者的心肌、肝脏、胰腺T2*中位数分别为27.7(3.2～45.4)ms、1.8(0.7～18.6)ms及6.1(1.1～42.9)ms;诊断心肌铁沉积(T2*<20 ms)34例(31.2％),肝脏铁沉积(T2*<6.3 ms)101例(92.7％),胰腺铁沉积(T2*<26 ms)92例(84.4％);诊断心肌铁沉积最小年龄7岁,肝脏和胰腺铁沉积最小年龄均为5岁.心肌T2*值与肝脏、胰腺T2*值均呈正相关(r分别为0.453、0.597,P均<0.001).A组肝脏T2*值低于B组(Z=3.048,P=0.002),C组胰腺T2*值低于D组(Z=6.682,P<0.001).肝脏、胰腺R2*(1/T2*)预测心肌铁沉积的ROC结果如下:曲线下面积分别为0.660(P=0.009)、0.933(P<0.001),95％置信区间分别为(0.543～0.777)、(0.881～0.985).[结论]β-TM患者肝脏、胰腺铁沉积的发生较早、且普遍,早于心肌铁沉积.肝脏、胰腺铁沉积与心肌铁沉积相关,两者结合可用于预测心肌铁沉积的情况.

目的 对比分析MS BLOCK T1rho、MS HS8 T1rho及3D BLOCK T1rho序列肝脏MR图像质量及T1rho值.方法 分别采用MS BLOCK T1rho(n=33)、MS HS8 T1rho(n=34)及3D BLOCK T1 rho(n-22)序列对40名成年健康志愿者行腹部MR扫描,比较3种序列肝脏图像质量及T1 rho值,以Pearson相关分析观察3种序列T1 rho值的相关性.结果 3种序列的图像质量评分及T1 rho值差异均有统计学意义(P均＜0.01),其中MS HS8 T1rho图像质量评分及T1rho值均高于其他2种序列(P均＜0.05).MS BLOCK T1rho序列图像的T1rho值与MS HS8 T1rho、3D BLOCKT1rho均呈正相关(r=0.59、0.73,P均＜0.05),MS HS8 T1rho的T1 rho值与3D BLOCK T1rho呈正相关(r=0.72,P＜0.05).结论 MS BLOCK T1rho、MS HS8 T1rho及3D BLOCK T1rho序列均可应用于健康人肝脏MR成像,但用于诊断肝脏疾病时需设定不同的参考值范围.

目的 探讨原发性纵隔非典型脑膜瘤的临床及影像学表现.方法 分析我院一例原发性纵隔非典型脑膜瘤的临床表现、实验室检查、影像学及病理学特征,并结合文献进行回顾,总结该病的临床、病理及影像学特征.结果 患者进行实验室及影像学检查后,行纵隔肿物切除术,术后恢复良好.结论 原发性纵隔非典型脑膜瘤的组织来源及结构与颅内钙化型脑膜瘤一致,故有脑膜瘤的影像学特征,熟悉其影像学特征及病理改变,有助于对该病的诊断及鉴别诊断.

目的 探讨T1rho技术定量诊断大鼠肝纤维化的价值.方法 选取45只SD大鼠为实验组,以腹腔注射40％ CCl4橄榄油溶液的方法制备肝纤维化模型;另选取12只SD大鼠为对照组,腹腔注射等量生理盐水.于给药后第1、2、4、6、8、10周分别取实验组5～6只大鼠和对照组2只大鼠进行MR T1rho扫描.完成检查后取肝脏进行病理检查,并进行肝纤维化分级.结果 肝纤维化F0～F6级大鼠肝脏的T1 rho值分别为(40.68±1.60) ms、(42.80±1.08) ms、(44.98±1.04)ms、(46.47±3.47)ms、(47.73±3.84)ms、(55.38±7.46)ms及(57.08±5.11)ms,总体差异有统计学意义(F=30.72,P＜0.01).大鼠肝脏T1rho测量值与肝纤维化分级呈正相关(r=0.88,P＜0.01);α-SMA表达水平与肝纤维化分级呈正相关(r=0.74,P＜0.01),与T1rho值亦呈正相关(r=0.57,P＜0.01).结论 MR T1rho可用于定量、无创性评估大鼠肝纤维化程度.

BACKGROUND:Regional lymph node metastasis in patients with hepatocellular carcinoma (HCC) is not uncommon, and is often under- or misdiagnosed. Regional lymph node metastasis is associated with a negative prognosis in patients with HCC, and surgical resection of lymph node metastasis is considered feasible and efficacious in improving the survival and prognosis. It is critical to characterize lymph node preoperatively. There is currently no consensus regarding the optimal method for the assessment of regional lymph nodes in patients with HCC.AIM:To evaluate the diagnostic value of single source dual energy computed tomography (CT) in regional lymph node assessment for HCC patients.METHODS:Forty-three patients with pathologically confirmed HCC who underwent partial hepatectomy with lymphadenectomy were retrospectively enrolled. All patients underwent dual-energy CT preoperatively. Regional lymph nodes (n = 156) were divided into either a metastatic (group P, n = 52) or a non-metastasis group (group N, n = 104), and further, according to pathology, divided into an active hepatitis (group P1, n = 34; group N1, n = 73) and a non-active hepatitis group (group P2, n = 18; group N2, n = 31). The maximal short axis diameter (MSAD), iodine concentration (IC), normalized IC (NIC), and the slope of the spectral curve (λ HU) of each group in the arterial phase (AP), portal phase (PP), and delayed phase (DP) were analyzed.RESULTS:Analysis of the MSAD, IC, NIC, and λ HU showed statistical differences between groups P and N (P < 0.05) during all three phases. To distinguish benign from metastatic lymph nodes, the diagnostic efficacy of IC, NIC, and λ HU in the PP was the best among the three phases (AP, PP, and DP), with a sensitivity up to 81.9%, 83.9%, and 81.8%, and a specificity up to 82.4%, 84.1% and 84.1%, respectively. The diagnostic value of combined analyses of MSAD with IC, NIC, or λ HU in the PP was superior to the dual energy CT parameters alone, with a sensitivity up to 84.5%, 86.9%, and 86.2%, and a specificity up to 83.0%, 93.6% and 89.8%, respectively. Between groups P1 and P2 and groups N1 and N2, only IC, NIC, and λ HU between groups N1 and N2 in the PP had a statistically significant difference (P < 0.05).CONCLUSION:Dual-energy CT contributes beneficially to regional lymph node assessment in HCC patients. Combination of MSAD with IC, NIC, or λ HU values in the PP is superior to using any single parameter alone. Active hepatitis does not deteriorate the capabilities for characterization of metastatic lymph nodes.

目的 探讨假肌源性血管内皮瘤的临床及影像学表现.方法 分析我院一例假肌源性血管内皮瘤的临床表现、实验室检查、影像学及病理学特征,并结合文献进行回顾,总结该病的临床、病理及影像学特征.结果 患者进行实验室及影像学检查后,行右侧髂骨肿物及右臀部皮下肿物切除术,术后恢复良好.结论 假肌源性血管内皮瘤是一种少见的低～中度恶性的血管内皮瘤,影像学上具有软组织肿瘤的特点,熟悉其临床表现、影像学及病理学特征,有助于对该病的诊断及鉴别诊断.

目的 探讨儿童颌面部横纹肌肉瘤的MRI影像学表现及其临床特点.方法 回顾性分析我院10例经手术病理证实的儿童颌面部横纹肌肉瘤的临床特点及其MRI表现,并进行文献回顾.结果 10例儿童颌面部横纹肌肉瘤中,发病于颞部者7例,发病于上颌、下颌及咽旁各1例.肿瘤形态不规则,边界稍欠清,MRI上T1WI呈等或稍低信号,T2WI呈稍高或高信号,DWI弥散受限,增强扫描呈明显不均匀强化.肿瘤呈浸润性生长,4例侵犯腮腺,6例侵犯耳道,3例侵犯咽,5侵犯邻近肌肉,6例骨质破坏,3例推压颈内动脉及颈动脉鞘,2例向上延伸至颅底.结论 儿童颌面部横纹肌肉瘤好发于颞部,受累范围较大,侵犯邻近肌肉并形成骨质破坏.MRI能清晰显示肿物及其边界,周围软组织浸润范围及骨质破坏情况,提供全面的影像诊断信息.

The present study was designed to prove our concept that a 3-dimensionally (3D) printed mold could be used as a guide for breast-conserving surgery. Eight breast cancer patients were included in the study. Negative margins were achieved in all 8 patients with less normal breast tissue sacrificed. These results indicate that 3D printed molds used to guide a procedure is a feasible method for breast-conserving surgery. Purpose: In this proof-of-concept study, we proposed 3-Deprinted mold-guided breast-conserving surgery (BCS) in breast cancer patients. Patients and Methods: Pathologically confirmed and eligible breast cancer patients received magnetic resonance imaging examinations before BCS. The information on the shape, size, and location of the tumor relative to the nipple was extracted and analyzed. We used a 3-D printing technique to produce a mold to guide BCS for breast cancer patients. Results: We performed 3-Deprinted mold-guided BCS in 8 breast cancer patients. All of the patients had negative surgical margins, confirmed by intraoperative and postoperative pathologic examinations. Conclusion: The 3-D-printed mold-guided BCS approach is a feasible way to achieve negative surgical margins. A prospective designed cohort study, with more patients included and a longer follow-up, is needed to further confirm its long-term oncologic safety. (C) 2018 Elsevier Inc. All rights reserved.

Objective: To investigate the clinical significance of Gd-EOB-DTPA to predict and evaluate the liver function. Materials and Methods: Gd-EOB-DTPA-enhanced MR images of 98 patients were conducted on a 3.0 Tesla MRI. The values of relative enhancement ratio (rER) and Child-Pugh scores were calculated. Serologic testing was obtained within 7 days before and after MRI. The comparison between different Child-Pugh groups was accomplished by One-Way ANOVA. Spearman rank correlation was applied to analyze the relationship between the rER values and serologic results. Results:The results showed statistical differences among rER values of different Child-Pugh groups and normal group (P<0.05). The mean values are respectively 2.281±0.275, 2.092±0.474,1.824±0.246, 1.711±0.433. Comparative analysis between every two groups was applied and the results showed that normal and Child-Pugh B, normal and Child-Pugh C, Child-Pugh A and Child-Pugh B indicated statistical significance. The linear regression analysis showed that P value between rERs and values of TBIL, ALT, AST, PT, PTA, PA, ChE were less than 0.05, which was significant statistically. Conclusions: The rER values of EOBMRI could be used to evaluate liver function and to identify mild, moderate liver damage significantly. It got the most intimate relation with prothrombin activity and prealbumin.

Endometrial cancer is one of the three most common gynecologic malignancies.With high soft tissue resolution,multi-dimensional and multi-sequencing imaging,magnetic resonance imaging (MRI) has become an important method for preoperative staging of endometrial carcinoma.Conventional MRI plays an important role in preoperative staging,but still has some limitations.Functional MRI,such as diffusion weighted imaging (DWI) and dynamic contrast enhanced MRI (DCE-MRI),has great potential in preoperative staging.This review provides an overview of current conventional and novel imaging methods for preoperative staging of endometrial cancer.

To determine the capacity of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in differential diagnosis between recurrent carcinoma and postchemoradiation fibrosis of skull base in patients with nasopharyngeal carcinoma (NPC).

PurposeTo evaluate the value of T2, T1rho, and diffusion metrics in assessment of liver fibrosis in rats.Materials and MethodsLiver fibrosis in a rat model (n = 72) was induced by injection of carbon tetrachloride (CCl4) at 3T. T2, T1rho, and diffusion parameters (apparent diffusion coefficient (ADC), Dtrue) via spin echo (SE) diffusion‐weighted imaging (DWI) and stimulated echo acquisition mode (STEAM) DWI with three diffusion times (DT: 80, 106, 186 msec) were obtained in surviving rats with hepatic fibrosis (n = 52) and controls (n = 8). Liver fibrosis stage (F0–F6) was identified based on pathological results using the traditional liver fibrosis staging method for rodents. Nonparametric statistical methods and receiver operating characteristic (ROC) curve analysis were employed to determine the diagnostic accuracy.ResultsMean T2, T1rho, ADC, and Dtrue with DT = 186 msec correlated with the severity of fibrosis with r = 0.73, 0.83, −0.83, and −0.85 (all P < 0.001), respectively. The average areas under the ROC curve at different stages for T1rho and diffusion parameters (DT = 186 msec) were larger than those of T2 and SE DWI (0.92, 0.92, and 0.92 vs. 0.86, 0.82, and 0.83). The corresponding average sensitivity and specificity for T1rho and diffusion parameters with a long DT were larger (89.35 and 88.90, 88.36 and 89.97, 90.16 and 87.13) than T2 and SE DWI (90.28 and 79.93, 85.30 and 77.64, 78.21 and 82.41). The performances of T1rho and Dtrue (DT = 186 msec) were comparable (average AUC: 0.92 and 0.92).ConclusionAmong the evaluated sequences, T1rho and STEAM DWI with a long DT may serve as superior imaging biomarkers for assessing liver fibrosis and monitoring disease severity.Level of Evidence: 1J. Magn. Reson. Imaging 2017;45:741–750.

PURPOSE:The relationship between severe liver iron overload (LIO) and heart iron overload (HIO) in transfusion-dependent patients with thalassemia major (TM) is uncertain. Whether severe LIO can serve as an index for assessing heart iron deposition has vital clinical significance. Therefore, our aim is to determine if a close relationship exists between severe LIO and HIO. MATERIALS AND METHODS:We examined 110 TM patients who underwent T2* measurement in the liver and heart on a 1.5 Tesla MRI scanner. Various statistical analysis methods were used to assess the relationship. RESULTS:Most of these patients suffered from severe LIO (58.18%, liver T2* < 1.4 ms). Both Pearson's and Spearman's tests showed a significant correlation between liver T2* and heart T2* values (with a correlation coefficient of 0.408 and 0.550, respectively, both P < 0.0001). A nonlinear model, with the equation of Heart T2* = 37.974-17.684 / Liver T2*, was found to be the best model to indicate the relationship between liver T2* and heart T2*. Receiver operating characteristic (ROC) analysis showed the area under the ROC curve of liver T2* and serum ferritin for predicting HIO was 0.812 (95% confidence interval [CI]: 0.731-0.892; P < 0.0001) and 0.69 (95% CI: 0.585-0.795; P = 0.001), respectively. CONCLUSION:Our preliminary data suggest the existence of a close relationship between severe LIO and HIO. High liver iron levels appear to increase the risk of heart iron deposition. This further supports the concept of critical liver iron concentration, above which elevated heart iron is present. J. MAGN. RESON. IMAGING 2016;44:880-889.

PurposeTo compare visual quality and quantitative measurements of multislice (MS) breath-hold and 3D respiratory-triggered T-1 sequences.Materials and MethodsT(1) scans including MS BLOCK T-1, MS HS8 T-1, and 3D BLOCK T-1 were performed on 40 healthy volunteers and 17 liver cirrhosis patients on 3.0T magnetic resonance imaging (MRI). The MS breath-hold methods scanned three slices while the 3D method covered 26 slices. Visual scores of image quality, T-1 measurements of the three sequences, and T-1 values of healthy volunteers and cirrhosis patients were compared using parametric tests.ResultsAverage visual scores for volunteers and patients of the three sequences were 3.19 and 2.82 for MS BLOCK T-1; 3.71 and 3.59 for MS HS8 T-1; 3.29 and 3.59 for 3D BLOCK T-1, respectively. Difference of visual scores among the three groups was significant (P < 0.001). Differences in T-1 values among the three methods were significant (P < 0.001). Difference of T-1 between MS BLOCK T-1 and 3D BLOCK T-1 was not significant (volunteer: P = 0.82, patient: 0.92) while the difference of T-1 between MS BLOCK T-1 and MS HS8 T-1, MS HS8 T-1 and 3D BLOCK T-1 was significant in both volunteers and patients (P < 0.01). Differences of T-1 between healthy volunteers and patients were all significant in three T-1 sequences (P = 0.04, 0.004, 0.03).ConclusionOf the tested sequences, the image quality of MS HS8 T-1 was best, but 3D BLOCK T-1 with respiratory triggering should also be considered as an alternative sequence for clinical diagnosis of liver cirrhosis due to its superior coverage. J. MAGN. RESON. IMAGING 2016;44:906-913.