目的 探讨基于数据挖掘的中医药治疗小儿惊风处方用药规律.方法 对中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)和万方数据知识服务平台建库至2018年8月关于中医治疗小儿惊风的文献进行检索,通过数据筛选清理,将符合要求的文献建立数据库,采取频数分析方法对方剂中使用药物种类、归经以及选药规律进行分析.结果 共搜集文献处方64个,使用药物共计263味,使用频次最高的前5位:钩藤、僵蚕、连翘、甘草、白芍.所用药物的主要功效:清热解毒、疏散风热、息风定惊、清热平肝、息风止痉.所用药物归经:肺、肝、心.药物平均剂量:约成人的四分之一.常用及最佳药对组合:僵蚕与钩藤.结论 小儿惊风的方剂以清热息风,平肝定惊止痉为主,用药针对性较强.基于"古今医案云平台"的数据挖掘可以反映中医治疗小儿惊风的用药规律,对临床和用药传承及交流具有重要指导作用.

OBJECTIVETo investigate the effects of traditional Chinese medicine (TCM) therapy for clearing heat and resolving phlegm on systemic inflammatory response syndrome (SIRS) in acute deterioration stage of chronic obstructive pulmonary disease (COPD) and the serum procalcitonin (PCT) level.METHODSOne hundred patients suffering from SIRS in acute deterioration stage of COPD were included and randomly divided into treatment group (50 cases) and control group (50 cases). Patients in the treatment group were treated with routine Western medicine and Chinese herbal medicine for clearing away heat and eliminating phlegm, while patients in the control group were treated with routine Western medicine only. Patients in the two groups were treated for one week. The serum PCT levels in the two groups were measured at days 1, 3, and 7, and clinical symptom scores were recorded at days 1 and 7 in hospital to determine the effects.RESULTSClinical symptom scores in the two groups decreased after the treatment (P<0.05), and the symptom score in the treatment group was lower than that in the control group (P<0.05). The effect of integrated traditional Chinese and Western medicine treatment was obviously better than that of the Western medicine treatment when improving rates in clinical symptom score were divided into over 70% and less than 70% (P<0.05). Serum PCT concentration was in direct proportion to clinical symptom score (P<0.05). The patients with higher clinical symptom score were in more serious pathogenetic condition. There were no significant differences in the serum PCT concentrations among days 1, 3 and 7 in hospital.CONCLUSIONThe effect of TCM therapy for clearing heat and removing phlegm combined with Western medicine treatment is better than that of the Western medicine treatment. TCM therapy has a satisfied effect in improving clinical symptoms. The serum PCT concentration is correlated with the severity of SIRS in acute deterioration stage of COPD.