Non cliral and chiral NADH models in the pyrrolo [2,3-b] pyridine series have been synthesized. These reagents 1) allow reductions of substrates previously found to be non reducible with similar reagents, 2) can give either one enantiomer or the other during the reduction of a prochiral ketone depending on the experimental conditions, 3) can be used in the synthesis of chiral precursors of target molecules obtained with good enantiomeric excesses.
AbstractThe thienopyridine derivative (IV), functionalized on the thiophene ring, is synthesized by construction of a pyridine ring starting from the thiophene (I).
AbstractThieno[2,3‐b]pyridine derivatives, functionalized on the thiophene ring have been synthesized in two different ways: electrophilic substitution of thieno[2,3‐b]pyridine derivatives or construction of a pyridine ring starting from disubstituted thiophene compounds. The products obtained were used in the synthesis of chiral NADH models.
ChemInformVolume 19, Issue 19 Heterocyclic Compounds ChemInform Abstract: Facile Synthesis of Annelated NADH Model Precursors. R. BENOIT, R. BENOIT Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorG. DUPAS, G. DUPAS Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorJ. BOURGUIGNON, J. BOURGUIGNON Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorG. QUEGUINER, G. QUEGUINER Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this author R. BENOIT, R. BENOIT Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorG. DUPAS, G. DUPAS Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorJ. BOURGUIGNON, J. BOURGUIGNON Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this authorG. QUEGUINER, G. QUEGUINER Lab. Chim. Org. Fine Heterocycl., 76130 Mont Saint Aignan, FranceSearch for more papers by this author First published: May 10, 1988 https://doi.org/10.1002/chin.198819194AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume19, Issue19May 10, 1988 RelatedInformation