Background: Sacroiliac joint fusion (SIF) has been shown to effectively alleviate pain and improve functional deficits associated with sacroiliac joint dysfunction (SIJD). Previous studies have demonstrated significant improvements in gait function, however, none have reported both over-ground walking and quiescent standing, and additionally, none have included analysis of pelvic kinematics which may contain important information regarding pain avoidant compensatory behaviors. The purpose of this study was to identify objective functional differences between symptomatic and asymptomatic sides of unilateral sacroiliac joint dysfunction (SIJD) patients and to demonstrate the effectiveness of unilateral sacroiliac fusion (SIF) to improve gait and balance function compared to matched controls. Methods: Thirteen unilateral SIJD patients were evaluated before and 6 months after SIF and were compared to matched asymptomatic controls. Pain and disability were assessed using visual analog scales and the Oswestry disability index respectively. Over ground walking and standing balance were assessed using 3D joint kinematics and kinetic ground reaction force analyses. Results: Preoperatively, SIJD patients reported high levels of pain and disability and exhibited significant deficits in gait including elevated step width, reduced hip flexion/extension, and elevated pelvic motion as well as elevated center of pressure sway characteristics during standing. After unilateral SIF, patients reported significant reductions in pain and demonstrated significant improvements in gait including normalization of step width between sides and improved hip motion however elevated pelvic obliquity and rotation motion remained. Improvements in standing balance included reduced coronal sway characteristics and normalization of loading symmetry between sides. Conclusion: Unilateral SIF resulted in significant improvements in both gait and balance function among SIJD patients to levels comparable to matched controls, however elevated pelvic motion remained. These findings help inform surgeons on the effectiveness of SIF for unilateral SIJD and provide important information regarding interpretation of functional outcomes.

BACKGROUND CONTEXT While spine surgery can produce good outcomes in many patients, there are patients who do not benefit from the intervention and have conditions not thought not to be addressable by surgical intervention. These failed back surgery syndrome (FBSS) patients may be candidates for spinal cord stimulation (SCS) for pain management. While multiple studies have reported benefits of SCS related to pain reduction, improved quality of life, and reduced pain medication intake, there has been little investigation into measurable physical functional improvement in this population. PURPOSE The purpose of this study was to evaluate the effect of SCS on traditional self-reported pain and functional measures, the psychological parameter of kinesiphobia, as well as functional measures of balance and gait, in FBSS patients. STUDY DESIGN/SETTING Prospective repeated-measures design. PATIENT SAMPLE A total of 15 symptomatic FBSS patients eligible for SCS. OUTCOME MEASURES Outcome assessment was based on visual analog scales (VAS) for back and leg pain, Oswestry Disability index (ODI), Tampa Scale for Kinesiophobia (TSK) and functional testing components including balance, sway and gait. METHODS Patients completed patients reported outcomes and functional evaluations prior to the SCS trial procedure (Pre) and at 6 (Post6) and 12 (Post12) weeks after SCS implantation. Gait and balance were evaluated using 3D human motion capture and dynamic surface EMG. Balance effort and Cone of Economy (CoE) dimensions were as measured by total sway and range of sway (RoS), respectively. Repeated measurements and one-way analysis of variance (ANOVA) were used to analyze data. RESULTS SCS implant significantly improved gait and balance in FBSS patients. The following gait parameters showerd significant improvement: Walking speed (Pre: 0.75, Post6: 0.86, Post12: 0.92 m/s, p<0.011), cadence (Pre: 85.42, Post6: 94.1, Post12: 95.94 steps/m, p<0.032), stride length (Pre: 0.98, Post6: 1.05, Post12: 1.07 m, p<0.049), and gait deviation index (GDI; Pre: 74.0, Post6: 83.2, Post12: 90.8, p<0.012). Additionally, significant improvements were seen in balance effort (head sway, Pre: 80.2, Post6: 52.2, Post12: 50.0 cm, p<0.049) sway dimensions as seen by reduced sagittal (p<0.047) and coronal (p<0.042) sway. For patient-reported outcomes, significant improvements were noted for VAS low back (Pre: 6.5, Post6: 3.6, Post12: 3.9, p<0.036), ODI (Pre: 57.6, Post6: 39.7, Post12: 38.3, p<0.006). Scores on the and TSK also improved significantly (p<0.044). CONCLUSIONS The results of this study support prior literature reporting significant improvement in pain and self-reported function reflected in VAS and ODI scores. Additionally, significant improvements were found post-SCS in gait and balance. The results suggest that SCS is associated not only with significant improvement in patient self-reported outcome measures, but also with physical functional testing. The patients included in this study showed more efficient gait patterns and improves balanced. This may be reflective of an overall improvement in activities of daily living following SCS implantation. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs. While spine surgery can produce good outcomes in many patients, there are patients who do not benefit from the intervention and have conditions not thought not to be addressable by surgical intervention. These failed back surgery syndrome (FBSS) patients may be candidates for spinal cord stimulation (SCS) for pain management. While multiple studies have reported benefits of SCS related to pain reduction, improved quality of life, and reduced pain medication intake, there has been little investigation into measurable physical functional improvement in this population. The purpose of this study was to evaluate the effect of SCS on traditional self-reported pain and functional measures, the psychological parameter of kinesiphobia, as well as functional measures of balance and gait, in FBSS patients. Prospective repeated-measures design. A total of 15 symptomatic FBSS patients eligible for SCS. Outcome assessment was based on visual analog scales (VAS) for back and leg pain, Oswestry Disability index (ODI), Tampa Scale for Kinesiophobia (TSK) and functional testing components including balance, sway and gait. Patients completed patients reported outcomes and functional evaluations prior to the SCS trial procedure (Pre) and at 6 (Post6) and 12 (Post12) weeks after SCS implantation. Gait and balance were evaluated using 3D human motion capture and dynamic surface EMG. Balance effort and Cone of Economy (CoE) dimensions were as measured by total sway and range of sway (RoS), respectively. Repeated measurements and one-way analysis of variance (ANOVA) were used to analyze data. SCS implant significantly improved gait and balance in FBSS patients. The following gait parameters showerd significant improvement: Walking speed (Pre: 0.75, Post6: 0.86, Post12: 0.92 m/s, p<0.011), cadence (Pre: 85.42, Post6: 94.1, Post12: 95.94 steps/m, p<0.032), stride length (Pre: 0.98, Post6: 1.05, Post12: 1.07 m, p<0.049), and gait deviation index (GDI; Pre: 74.0, Post6: 83.2, Post12: 90.8, p<0.012). Additionally, significant improvements were seen in balance effort (head sway, Pre: 80.2, Post6: 52.2, Post12: 50.0 cm, p<0.049) sway dimensions as seen by reduced sagittal (p<0.047) and coronal (p<0.042) sway. For patient-reported outcomes, significant improvements were noted for VAS low back (Pre: 6.5, Post6: 3.6, Post12: 3.9, p<0.036), ODI (Pre: 57.6, Post6: 39.7, Post12: 38.3, p<0.006). Scores on the and TSK also improved significantly (p<0.044). The results of this study support prior literature reporting significant improvement in pain and self-reported function reflected in VAS and ODI scores. Additionally, significant improvements were found post-SCS in gait and balance. The results suggest that SCS is associated not only with significant improvement in patient self-reported outcome measures, but also with physical functional testing. The patients included in this study showed more efficient gait patterns and improves balanced. This may be reflective of an overall improvement in activities of daily living following SCS implantation.

BACKGROUND CONTEXT The sacroiliac joint (SIJ) is an underappreciated pain generator in 15-30% of patients with low back pain. The SIJ functions as a primary structure which transfers loads of the upper body to the lower extremities. Sacroiliac joint dysfunction (SIJD) is characterized by SIJ laxity with symptoms manifesting primarily as low back and lower extremity pain. Additionally, there is growing evidence that gait patterns may also be affected by SIJD. Although there is still much controversy, minimally invasive sacroiliac fusion (SIF) is gaining interest as a procedure for SIJD patients with unremitting pain. SIF aims to reduce SI pain by stabilizing the SIJ and improving structural support between the sacrum and ilium. While positive outcomes for improved pain and reduced opioid consumption have been associated with SIF, there is a lack of research concerning the effects of SIF on functional biomechanics such as gait performance. PURPOSE To quantify the effects of SIF on biomechanical gait parameters of SIJD patients at three months postoperative follow-up compared to their preoperative state. STUDY DESIGN/SETTING Non-randomized, prospective, concurrent cohort study. PATIENT SAMPLE Twelve symptomatic SIJD patients. OUTCOME MEASURES Spatiotemporal parameters, gait range-of-motion (RoM) parameters, and patient-reported outcomes. METHODS Clinical gait analysis was performed one week before surgery (Pre) and three months after surgery (Post). Each patient performed a series of over-ground gait trials at a comfortable, self-selected speed. Data were collected using a motion capture system and three force plates. Back and leg Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Fear Avoidance Beliefs Questionnaire (FABQ), Tampa Scale for Kinesiophobia (TSK), and Demoralization Scale (DS) scores were also collected at both time points. RESULTS Patients showed increased cadence (Pre: 98.39 vs Post: 106.95 steps/min, p=0.018) and walking speed (Pre: 0.87 vs Post: 1.03 m/s, p=0.013). Patients also showed decreases in stride time (Pre: 1.28 vs Post: 1.14 s, p=0.015), step time (Pre: 0.65 vs Post: 0.58 s, p=0.015), and double-support time (Pre: 0.37 vs Post: 0.29 s, p=0.024). Patients show significant decreases in both knee RoM (Pre: 15.25 vs Post: 10.79°, p=0.02) and head motion (Pre: 4.80 vs Post: 3.18 °, p=0.045) in the coronal plane. VAS leg pain score (Pre: 4.25 vs Post: 2.69, p=0.032) improved significantly postoperatively. CONCLUSIONS SIJD patients treated with SIF showed significant improvements in functional gait and leg pain at their three-month follow-up. The results suggest that SIF provides improved lateral stability which in turn results in more efficient knee motion and improved cadence and step efficiency. The improved leg VAS scores reflect this notion as well. The lack of more pronounced improvements in gait and reported outcomes may be due to insufficient follow-up time to account for a full recovery following SIF. This study may serve as a basis for future diagnostic techniques which utilize gait pattern evaluation as an indicator for early development of SIJD. The findings of this study highlight the impacts that SIJD can have on patients daily lives and reinforces the importance of recognizing the SIJ as a contributor to the functional ability of an individual. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs. The sacroiliac joint (SIJ) is an underappreciated pain generator in 15-30% of patients with low back pain. The SIJ functions as a primary structure which transfers loads of the upper body to the lower extremities. Sacroiliac joint dysfunction (SIJD) is characterized by SIJ laxity with symptoms manifesting primarily as low back and lower extremity pain. Additionally, there is growing evidence that gait patterns may also be affected by SIJD. Although there is still much controversy, minimally invasive sacroiliac fusion (SIF) is gaining interest as a procedure for SIJD patients with unremitting pain. SIF aims to reduce SI pain by stabilizing the SIJ and improving structural support between the sacrum and ilium. While positive outcomes for improved pain and reduced opioid consumption have been associated with SIF, there is a lack of research concerning the effects of SIF on functional biomechanics such as gait performance. To quantify the effects of SIF on biomechanical gait parameters of SIJD patients at three months postoperative follow-up compared to their preoperative state. Non-randomized, prospective, concurrent cohort study. Twelve symptomatic SIJD patients. Spatiotemporal parameters, gait range-of-motion (RoM) parameters, and patient-reported outcomes. Clinical gait analysis was performed one week before surgery (Pre) and three months after surgery (Post). Each patient performed a series of over-ground gait trials at a comfortable, self-selected speed. Data were collected using a motion capture system and three force plates. Back and leg Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Fear Avoidance Beliefs Questionnaire (FABQ), Tampa Scale for Kinesiophobia (TSK), and Demoralization Scale (DS) scores were also collected at both time points. Patients showed increased cadence (Pre: 98.39 vs Post: 106.95 steps/min, p=0.018) and walking speed (Pre: 0.87 vs Post: 1.03 m/s, p=0.013). Patients also showed decreases in stride time (Pre: 1.28 vs Post: 1.14 s, p=0.015), step time (Pre: 0.65 vs Post: 0.58 s, p=0.015), and double-support time (Pre: 0.37 vs Post: 0.29 s, p=0.024). Patients show significant decreases in both knee RoM (Pre: 15.25 vs Post: 10.79°, p=0.02) and head motion (Pre: 4.80 vs Post: 3.18 °, p=0.045) in the coronal plane. VAS leg pain score (Pre: 4.25 vs Post: 2.69, p=0.032) improved significantly postoperatively. SIJD patients treated with SIF showed significant improvements in functional gait and leg pain at their three-month follow-up. The results suggest that SIF provides improved lateral stability which in turn results in more efficient knee motion and improved cadence and step efficiency. The improved leg VAS scores reflect this notion as well. The lack of more pronounced improvements in gait and reported outcomes may be due to insufficient follow-up time to account for a full recovery following SIF. This study may serve as a basis for future diagnostic techniques which utilize gait pattern evaluation as an indicator for early development of SIJD. The findings of this study highlight the impacts that SIJD can have on patients daily lives and reinforces the importance of recognizing the SIJ as a contributor to the functional ability of an individual.

The sacroiliac joint (SIJ) as a source of symptoms has been controversial; however, as knowledge about the joint increased, its role as a pain generator in patients complaining of symptoms that are often attributed to spinal pathology has become better appreciated. The literature reports that the SIJ is the pain origin in as many as 30% of patients presenting with low back pain. Clinically, the SIJ can be challenging to evaluate; however, assessing pain location, patient posture/movement, and provocative manual testing are useful in making the presumptive diagnosis of SIJ disruption. The most definitive evaluation is image-guided injection of anesthetic solutions into the joint which is diagnostic if there is at least 75% symptom relief acutely. Treatment begins with nonoperative intervention including physical therapy and/or chiropractic care. If these fail, the next option is generally radiofrequency denervation (rhizotomy) of the joint. If this does not provide adequate relief, surgical intervention, in the form of minimally invasive SIJ fusion may be considered. The literature increasingly supports favorable results of SIJ fusion in appropriately selected patients. The purpose of this review is to provide an overview of the current literature on the SIJ, with focus on its surgical treatment.

STUDY DESIGN:This was a prospective, randomized, controlled multicenter trial.OBJECTIVE:The purpose of this study was to compare clinical outcomes at 4-year follow-up of patients receiving cervical total disk replacement (TDR) with those receiving anterior cervical discectomy and fusion (ACDF).SUMMARY OF BACKGROUND DATA:ACDF has been the traditional treatment for symptomatic disk degeneration. Several studies found single-level TDR to be as safe and effective as ACDF at ≥2 years follow-up.METHODS:Patients from 23 centers were randomized in a 2:1 ratio with 164 receiving the investigational device (Mobi-C Cervical Disc Prosthesis) and 81 receiving ACDF using an anterior plate and allograft. Patients were evaluated preoperatively and 6 weeks, 3, 6, 12, 18, 24, 36, and 48 months postoperatively. Outcome assessments included a composite success score, Neck Disability Index, visual analog scales assessing neck and arm pain, patient satisfaction, major complications, subsequent surgery, segmental range of motion, and adjacent-segment degeneration.RESULTS:The composite success rate was similar in the 2 groups at 48-month follow-up. Mean Neck Disability Index, visual analog scale, and SF-12 scores were significantly improved in early follow-up in both groups with improvements maintained throughout 48 months. On some measures, TDR had significantly greater improvement during early follow-up. At no follow-up were TDR scores significantly worse than ACDF scores. Subsequent surgery rate was significantly higher for ACDF compared with TDR (9.9% vs. 3.0%, P<0.05). Range of motion was maintained with TDR having a mean baseline value of 8 degrees compared with 10 degrees at 48 months. The incidence of adjacent-segment degeneration was significantly higher with ACDF at inferior and superior segments compared with TDR (inferior: 50% vs. 30%, P<0.025; superior: 53% vs. 34%, P<0.025).CONCLUSIONS:Significant improvements were observed in pain and function. TDR patients maintained motion and had significantly lower rates of reoperation and adjacent-segment degeneration compared with ACDF. This study supports the safety and efficacy of TDR in appropriately selected patients.

Background Anterior cervical discectomy and fusion (ACDF) is the gold standard for treating symptomatic cervical disc degeneration. Cervical total disc replacements (TDRs) have emerged as an alternative for some patients. The purpose of this study was to evaluate the safety and effectiveness of a new TDR device compared with ACDF for treating single-level cervical disc degeneration. Methods This was a prospective, randomized, controlled, multicenter Food and Drug Administration (FDA) regulated Investigational Device Exemption (IDE) study. A total of 245 patients were treated (164 TDR: 81 ACDF). The primary outcome measure was overall success based on improvement in Neck Disability Index (NDI), no subsequent surgical interventions, and no adverse events (AEs) classified as major complications. Secondary outcome measures included SF-12, visual analog scale (VAS) assessing neck and arm pain, patient satisfaction, radiographic range of motion, and adjacent level degeneration. Patients were evaluated preoperatively and postoperatively at 6 weeks, 3, 6, 12, 18, and 24 months. The hypothesis was that the TDR success rate was non-inferior to ACDF at 24 months. Results Overall success rates were 73.6% for TDR and 65.3% for ACDF, confirming non-inferiority (p < 0.0025). TDR demonstrated earlier improvements with significant differences in NDI scores at 6 weeks and 3 months, and VAS neck pain and SF-12 PCS scores at 6 weeks (p<0.05). Operative level range of motion in the TDR group was maintained throughout follow-up. Radiographic evidence of inferior adjacent segment degeneration was significantly greater with ACDF at 12 and 24 months (p < 0.05). AE rates were similar. Conclusions Mobi-C TDR is a safe and effective treatment for single-level disc degeneration, producing outcomes similar to ACDF with less adjacent segment degeneration. Level of Evidence: Level I. Clinical relevance: This study adds to the literature supporting cervical TDR as a viable option to ACDF in appropriately selected patients with disc degeneration.

The sacroiliac (SI) joints are paired diarthrodial articulations of the sacrum and ilium and serve as the connection between the spine and pelvis. The small amount of motion in the joint (2-4 degrees) occurs primarily through nutation and counternutation of the sacrum.[1][1] There are no muscles

Object. Cervical total disc replacement (TDR) is intended to treat neurological symptoms and neck pain associated with degeneration of intervertebral discs in the cervical spine. Anterior cervical discectomy and fusion (ACDF) has been the standard treatment for these indications since the procedure was first developed in the 1950s. While TDR has been shown to be a safe and effective alternative to ACDF for treatment of patients with degenerative disc disease (DDD) at a single level of the cervical spine, few studies have focused on the safety and efficacy of TDR for treatment of 2 levels of the cervical spine. The primary objective of this study was to rigorously compare the Mobi-C cervical artificial disc to ACDF for treatment of cervical DDD at 2 contiguous levels of the cervical spine.Methods. This study was a prospective, randomized, US FDA investigational device exemption pivotal trial of the Mobi-C cervical artificial disc conducted at 24 centers in the US. The primary clinical outcome was a composite measure of study success at 24 months. The comparative control treatment was ACDF using allograft bone and an anterior plate. A total of 330 patients were enrolled, randomized, and received study surgery. All patients were diagnosed with intractable symptomatic cervical DDD at 2 contiguous levels of the cervical spine between C-3 and C-7. Patients were randomized in a 2:1 ratio (TDR patients to ACDF patients).Results. A total of 225 patients received the Mobi-C TDR device and 105 patients received ACDF. At 24 months only 3.0% of patients were lost to follow-up. On average, patients in both groups showed significant improvements in Neck Disability Index (NDI) score, visual analog scale (VAS) neck pain score, and VAS arm pain score from preoperative baseline to each time point. However, the TDR patients experienced significantly greater improvement than ACDF patients in NDI score at all time points and significantly greater improvement in VAS neck pain score at 6 weeks, and at 3, 6, and 12 months postoperatively. On average, patients in the TDR group also maintained preoperative segmental range of motion at both treated segments immediately postoperatively and throughout the study period of 24 months. The reoperation rate was significantly higher in the ACDF group at 11.4% compared with 3.1% for the TDR group. Furthermore, at 24 months TDR demonstrated statistical superiority over ACDF based on overall study success rates.Conclusions. The results of this study represent the first available Level I clinical evidence in support of cervical arthroplasty at 2 contiguous levels of the cervical spine using the Mobi-C cervical artificial disc. These results continue to support the use of cervical arthroplasty in general, but specifically demonstrate the advantages of 2-level arthroplasty over 2-level ACDF. Clinical trial registration no.: NCT00389597 (ClinicalTrials.gov).

Anterior cervical discectomy and fusion (ACDF) has been the treatment historically used for the treatment of degenerative disc disease (DDD) at one or two levels. Literature suggests that there is an increase in complication rates and a decrease in efficacy when ACDF is used at two contiguous levels versus a single level. There are few comparisons of TDR’s effectiveness in treatment of one-level versus two-level patients compared to ACDF. This study provides longer-term follow-up safety and effectiveness data focused on one-level versus two-level cervical TDR treated patients. This study provides comparative data that are not widely available in the literature.

Anterior cervical discectomy and fusion (ACDF) is the standard for treatment of cervical degenerative disc disease (DDD). Recent studies have shown that secondary surgery rates are higher with ACDF compared to cervical disc arthroplasty (CDA) at one level. The published data on two-level CDA use is increasing, though it not yet determined what, if any, difference exists in the comparative rate of second surgeries between two-level ACDF and CDA.

The clinical relevance of adjacent segment degeneration (ASD) following Cervical Disc Arthroplasty (CDA) or Anterior Cervical Discectomy and Fusion (ACDF) at two-levels is not fully understood. Research has shown the onset and/or progression of ASD associated with both CDA and ACDF, though specific preoperative risk factors linked to the onset of ASD have not been well defined. Further, the impact of new or progressive ASD on clinical outcomes has yet to be fully characterized for multi-level cervical procedures.

Spinal cord stimulation (SCS) is widely used for relief of chronic back and limb pain. However, numerous adverse events pose a hindrance to the widened acceptability of the treatment. A prospective, nonrandomized cohort study was conducted to compare the efficacy of a wirelessly powered SCS novel system with commercial SCS systems. Each of 12 patients were serially implanted with a Medtronic 1 × 8 SCS trial lead and a Stimwave Freedom trial lead for a 1-day evaluation. Patients were asked to report on pain relief, paresthesia coverage, paresthesia intensity, and paresthesia comfort. Ten of the 12 patients successfully underwent the trial whereas the remaining 2 procedures were terminated because of operating-equipment failures. Of the successful patients, all reported good pain relief and paresthesia for each device. The average pain reduction was reported as 80% for the Stimwave system and 66% for the Medtronic system. The average paresthesia coverage was 91% and 77%, respectfully. Differences in the averages reported by patients can be attributed to the fact that no randomization was designed in the study. The study showed that wirelessly powered, injectable SCS systems are just as effective as commercial products at relieving pain and at creating paresthesia coverage for patients who suffer from chronic back and limb pain and have the added advantages of shortened procedure time and elimination of open ports during the trial periods, as well as elimination of the need for tunneling and pocket creation for implantable pulse generators.

Infections due to extraintestinal pathogenic E. coli (ExPEC) are very common in humans as well as in animals. In humans ExPEC infections include urinary tract infections (UTI), septicemia, and wound infections, which result in significant morbidity, mortality, and substantial healthcare costs. In view of the increasing number of ExPEC infections caused by more and more resistant strains, effective prevention would be desirable. Given the rising treatment costs, a vaccine may be cost-effective in selected patient groups, such as women with recurrent UTI, patients with neurologic disorders impairing bladder function and men with prostate hyperplasia. Previous vaccine studies used single target proteins or whole inactivated ExPEC cells. Here, we describe a vaccine system for oral application based on artificial multiple subunit vaccine proteins. Those multi-epitope proteins are composed of predicted epitopes derived from ExPEC virulence-associated proteins. As ExPEC are known to form intracellular biofilms in the urothelium and can also resist killing by non-activated macrophages, T-cell responses are supposed to be an important measure to counteract these stages of ExPEC during infection. Therefore, a live bacterial antigen delivery system based upon the Salmonella type-III secretion system (T3SS) was used in this study to directly deliver the vaccine proteins into the cytoplasm of the host cells. Epitope-rich domains of the proteins FyuA, IroN, ChuA, IreA, Iha, and Usp were expressed in an attenuated Salmonella enterica serovar Typhimurium strain and translocated into target cells for extended periods of time inducing a strong T-cell response. No significant antibody titre increase against the secreted vaccine proteins could be detected in vaginal wash or serum. Despite that, one of the vaccine proteins was able to significantly reduce bacterial load in the challenge model of intraperitoneal sepsis. This study shows that a vaccine encompassing distinct epitopes of virulence-associated ExPEC proteins (i) can be applied for a T3SS-dependent vaccination strategy, (ii) elicits T-cell responses and (iii) confers protection after a single application.

The idea of forming a Texas Pain Society came to the Founders in 1987 due to disparity and deficiencies in the practice of pain management in the United States and, in particular, the State of Texas. The Founders considered very carefully the implication of forming such a society. They diligently mapped out the mission and goals of the Texas Pain Society in those early formative years. This report is the history of Texas Pain Society as the activities unfolded from 1989 to 2011. The reader may question why there is a need to tell such a story. We believe strongly that, with disparities of standards of practice in pain medicine and poor recognition of advances in pain management, this scenario is quite common in many states and countries. The practitioners of pain management in these regions certainly must have considered getting together and forming a consensus on the standards of practice in their communities. This historical report of the Texas Pain Society provides the relevant information necessary and the efforts to be made for a society's mission to achieve its goals and have an ongoing impact in its own region. We hope that we have shed some light on a process for the formation of a regional pain society such as ours.

Anterior cervical discectomy and fusion (ACDF) is performed as the surgical procedure of choice to manage intractable radiculo-myelopathy resulting from degenerative disc disease (DDD) of the cervical spine. Published research has provided evidence that the procedure may increase the stress on the adjacent cervical segments and accelerate degeneration at these levels. Total disc arthroplasty (TDA) using artificial disc has been proposed as an alternative procedure to possibly reduce the stress on adjacent segments by motion preservation.

Tuberculosis has global presence and no part of human body is immune to it, most frequent site beings lungs. Nasopharyngeal tuberculosis is a rare type of extrapulmonary tuberculosis comprising only less than 1% of tuberculosis found in the upper respiratory tract. The authors are presenting here a case of primary tuberculousis affecting the nasopharynx (adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass. Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas. In literature there are varied clinical presentations of nasopharyngeal tuberculosis. Tuberculosis should be one of the differential diagnosis of nasopharyngeal lesion. Biopsy and histologic study should be performed in every patient to avoid misdiagnosis. When treated properly, nasopharyngeal tuberculosis carries a excellent prognosis, and complete resolution of disease is the rule.

One of the difficulties in treating back pain is the multiple potential sources of pain, especially those occurring in the same general region. Pain in the low back or buttock may arise from muscle, disc, facet joints, sacroiliac joints, ligaments, etc. Trying to differentiate which structure(s) is responsible for pain presents a challenge. Once identified, the challenge of a viable treatment remains. Similar to the disc, the facets were traditionally thought to have a role in pain production by compressing the nerve roots. Not until years later did the innervation of these structures as well as the role of inflammatory mediators receive attention, and only then did an appreciation for these structures as primary pain generators come about. A spinal segment has frequently been described as a three-joint complex involving the intervertebral disc and the two facet joints. Based on biomechanical theory, many had accepted that facet degeneration is often a secondary occurrence following disc degeneration with a lesser incidence of primary facet injury or degeneration.

Study Design. This is a retrospective analysis of data that were collected prospectively from 2 concurrent FDA IDE lumbar arthroplasty clinical trials performed at a single center.Objectives. The purpose of this study was to determine if factors differentiating those patients with the best and worst clinical outcomes from total disc arthroplasty (TDR) could be identified.Summary of Background Data. Overall the results of TDR have been favorable, including recent results from 2 FDA IDE trials conducted in the United States. However, as with any surgical procedure, there were some patients with extremely good outcomes, and some with poor outcomes. If factors differentiating these groups could be identified, this may help refine patient selection criteria and improve future results.Methods. The databases of Charite and ProDisc patients at a single site were reviewed to identify patients who reached the 24-month follow-up period. A total of 203 patients, 63 who were implanted with the Charite prosthesis, and 140 who were implanted with the ProDisc prosthesis, were identified. The percentage change in the preoperative to postoperative VAS and Oswestry scores were used to identify the 10 best and 10 worst outcomes for each of the device types. Logistic regression analysis was conducted to determine which of a battery of demographic and clinical assessments were related to the best/worst group classification.Results. Results of the regression analysis found that the only factor significantly related to clinical outcome was the length of time off work before surgery. None of the demographic variables, preoperative VAS or Oswestry scores or radiographic assessment of device placement, were significantly related to clinical outcome. Patients who were off work for shorter durations, or not at all, were more likely to be in the best-outcome group compared with patients who were off work for an extended period of time before surgery.Conclusion. This study suggests that among patients undergoing TDR, the length of time off work before surgery was related to outcome. No additional factors related to the best/worst classification were identified in the current study.