Factors in the treatment of atopic dermatitis include restoring skin moisture and reducing inflammation. This study evaluated a corticoid oil formulation and its components with respect to their skin hydration potential. Ten healthy Caucasians were enrolled. Five test sites on the left and right forearm of each subject were tested: one site served as a normal skin control (without treatment), whereas four were wetted by spraying distilled water (approximately 0.1 ml) over a 3-cm2 skin surface area, and spraying was repeated every 5 min for a total of three applications. Five minutes after the final application, 0.2 ml of the corticoid oil formulation, moisturizing vehicle, and plain peanut oil were applied to each pre-designated site (3 cm2); one site was kept as a blank control (water saturation only). Thirty minutes later, test sites were gently wiped with paper tissues, and visual scoring, transepidermal water loss (TEWL), and capacitance were recorded and repeated at 2 and 3 h. The corticoid oil formulation, plain peanut oil, and moisturizing vehicle significantly increased skin hydration 30 min after each single application, with no statistically significant difference among the treatments at any point. The corticoid oil formulation and plain peanut oil slightly but not significantly elevated TEWL 30 min after application. The results support intuitive dermatologic judgment of advising patients to apply moisturizing medicaments after bathing.

:Despite the widespread use of relational database management systems, their decision support capabilities have been limited. These limitations include: (1) very limited support for expression of general statements and exceptions, (2) limited capabilities for what-if analysis, and (3) problems with the way derived data is handled. This paper shows that additional power can be placed in relational database systems via a new construct called Derived Relations with Exceptions (dres). Dres are a superset of relational views that provide greater decision support capabilities in that they handle exceptions to general rules and can operate in a hypothetical mode that provides an easier way to experiment with alternative scenarios in a what-if fashion. Dres are implemented by extending the SQL database language.