The metabolism of phenothiazine was studied in the guinea pig. In the adult animal after 24 hr, about 7% of the administered dose was found in feces, with traces of the sulfoxide and phenothiazone. Small amounts of all these compounds also were found in urine, with leucophenothiazone sulfate (approximately 12%) and a metabolite identified as phenothiazine N-glucuronide (approximately 22%). This latter compound was also present in bile. Both phenothiazine and its sulfoxide were retained in body tissues for a long time, about 85% of the dose being excreted after 7 days. In neonatal animals, phenothiazine, with up to 12% of the sulfoxide together with traces of leucophenothiazone, phenothiazone, and thionol was excreted in urine.
S.C. Mitchell合作论文数3Stephen C. Mitchell合作论文数3AC Williams合作论文数2T.W. Young合作论文数2L Klovrza合作论文数1JM NGONG合作论文数1HM FOSTER合作论文数1Hs Pall合作论文数1S. Green合作论文数1ML Smith合作论文数1MH DAVIES合作论文数1RL SMITH合作论文数1Co Mills合作论文数1
Marina de Tommaso合作论文数Medical Faculty, Aldo Moro University1Elwyn Elias合作论文数Department of Hepatology, Christian Medical College;Liver Unit, QE Hospital1R.L Smith合作论文数1
Sankar Kumar Acharya合作论文数Department of Gastroenterology, All India Institute of Medical Sciences1David B. Ramsden合作论文数Queen Elizabeth Medical Centre, University of Birmingham1Mine Yücesoy合作论文数1Glyn B. Steventon合作论文数1Riad Ayesh合作论文数1G.S. Panayi合作论文数1
Adrian Williams合作论文数School of Pharmacy, University of Reading1
Pietro Fiore合作论文数1Judith B. Weaver合作论文数1
