Eighty-three patients with ovarian cancer who had undergone radiation therapy, chemotherapy, or both were evaluated. Eight patients had FIGO stage I, 12 had stage II, 61 had stage III, and two had stage IV disease. In 60 patients, radiation was delivered with open abdominopelvic field (30 Gy over 4 weeks), with or without a pelvic boost dose. Fifty-five patients received a combination of chemotherapeutic agents, and 30 received a single agent as initial therapy. The patients were divided into three groups. The 26 patients in group 1 received primary radiation therapy with or without adjuvant single-agent chemotherapy. The 34 patients in group 2 underwent radiation therapy after chemotherapy failed. The 23 patients in group 3 received combination chemotherapy. Nineteen patients (23%) achieved complete remission--eight from group 1, two from group 2, and nine from group 3. The 5-year actuarial survival for group 1 was 41% but was only 16% for both groups 2 and 3 combined (P = .026). Primary radiation therapy, with or without adjuvant single-agent chemotherapy, was superior to combination chemotherapy in patients with ovarian cancer.

Forty patients with adenocarcinoma of the cecum who underwent right hemicolectomy received regional irradiation for 40-45 Gy/4-5 weeks and weekly 5-Fluorouracil (5-FU). Thirty-four patients received this adjuvant therapy: 12, 10, 5, 4 with Stage B2, B3, C2, C3, respectively, and 3 with abdominal metastasis. Another six patients were similarly treated for palliation because of tumor bed recurrences. Patients were followed for a median of 4 years, 21/31 patients in the adjuvant group with Stage B and C were free of disease with a median survival of 48 months (63% 5-year actuarial disease-free survival). The total local failure rate among the adjuvant group for Stage B and C was 4/31 (13%) with local failure alone occurring in 1 of 4 patients (3%). In the patients treated at our Hospital, there was significant improvement in the 5-year actuarial survival (p = 0.001) for patients with lymph node metastases who received adjuvant irradiation compared to surgery-alone. Acute radiation enteritis occurred in seven out of 40 patients (17.5%) and was severe in 2 (5%). There were no delayed complications. We conclude that adjuvant therapy markedly lowered regional recurrence and seems to improve survival in patients with lymph node metastasis when compared to a group of patients treated by surgery alone in the same institution.

Primary lymphocytic lymphoma of the meninges is a rare lesion. Several cases of lymphoma of spinal meninges have been reported. In 1959, Williams et al 1 described one of 118 lymphoma patients with a primary lymphocytic lymphoma of the spinal epidural space. In 1961, Bucy and Jerva 2 reported eight cases that they believed could be classified as primary lymphoma of the spinal epidural space. Other authors 3-5 have described a number of patients who had similar cases of primary lymphoma confined to the spinal canal. Only one previous reported case of lymphoma of the intracranial meninges could be found. 6 Recently, we have encountered such a lesion arising from the leptomeninges of the brain. We report this case because of its rare occurrence and the apparent favorable prognosis. REPORT OF A CASE A 59-year-old man was admitted to the Good Samaritan Hospital, Cincinnati, on July 30, 1978, with

One hundred and ninety-eight patients with the diagnosis of metastases to axilla or groin lymph nodes from cancer of unknown primary site, were seen at the Memorial Sloan-Kettering Cancer Center from 1949 to 1974.The patients' ages ranged from 15 to 85 years, and the ratio of male to female patients was 68 to 44 in the axilla group and 42 to 45 in the groin group.Initial investigations, pathological features, treatment methods with emphasis on radiation therapy, 5-year survival according to tumor extent and histologic type , subsequent findings including autopsy data, and prognosis according to site of lymph nodal ihvolvement, will be presented, (85) MENINGEAL CARCINOMATOSIS: