This chapter presents a general review of the misdirected reflex phenomenon in anurans, with reasons for rejecting selective peripheral regrowth as a class of mechanism by which cutaneous neurites could effectuate connexions with their appropriate sensory end organs. The refuted mechanisms include (1) peripheral searching, (2) multiple branching, and (3) the degeneration–regeneration of inappropriate neurites. The chapter reviews the data that argues against sensory impulse patterning as the source of cutaneous reflex localization. Behavioral observations, combined with nerve crush experiments, have shown that the peripheral nerve trunks that mediate only dorsal wiping responses in control frogs mediate misdirected, that is, ventrally directed wipes in skin-grafted animals. The cutaneous receptive fields (CRFs) for the nerve trunks are located in the same areas on the body surface in control and in skin-grafted animals, regardless of the type of skin present. Two experimental approaches might be useful to examine the alternative to the mechanism of modulation. One would be the use of early embryonic skin rotations, coupled with behavioral observations immediately after metamorphosis. The second proposed experimental approach would employ H3-thymidine autoradiography to establish the birthdates of neurons within the dorsal root ganglion (DRG).