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Robert Schreiber | AMiner学者主页 | AMiner

Robert Schreiber

Department of Pathology & Immunology School of Medicine Washington University Center for Human Immunology and Immunotherapy Programs Washington University Siteman Comprehensive Cancer Center Washington University

480Papers / 论文

10万Citations / 引用

120H-Index

浏览量235

个人简介

My research is focused on elucidating the cellular and molecular mechanisms underlying natural and therapeutically induced immune responses to developing and established cancers. My group was the first to propose the concept of “Cancer Immunoediting” wherein the immune system not only protects against cancer but also favors cancer outgrowth by shaping tumor cell immunogenicity. We went on to provide strong experimental evidence supporting each of the three phases of the cancer immunoediting process—Elimination, Equilibrium and Escape. We produced a variety of gene-targeted mice and used them to obtain genetic evidence for the roles of various cytokines, receptors and signaling pathways in the cancer immunoediting process. In the process, we also developed a model of mouse mammary cancer that displays remarkable similarities to human luminal breast cancer. During my career, my lab generated a number of key monoclonal antibody reagents that neutralize cytokines or block cytokine receptors and validated their in vivo use to assess the role of cytokines in preventing or inducing diseases particularly cancer.

教育经历

1968-1973 Jacobs of Medicine and Biomedical Sciences at the University at Buffalo PhD, Biochemistry and Immunology
1964-1968 State University of New York at Buffalo B.A., Chemistry

工作经历

Postdoc: (Immunology) Research institute of Scripps Clinic (1973-1976)
Aug 1985-Present Washington University in Saint Louis Andrew M and Jane M Bursky Professor of Pathololgy and Immunology
Director, Center for Human Immunology and Immunotherapy Programs
Co-Leader, Tumor Immunology Program, Siteman Comprehensive Cancer Center

全面呈现 [Robert Schreiber] 的学术影响力

深度挖掘高质量成果与权威引用，让优秀看得见

研究兴趣

198220212024

论文（480）

专利

基金项目

按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选

1Supplementary Figure S6 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S6: Characterization of antigen-specific CD8+ T cells in MC38 tumors.

2026

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2Supplementary Figure S3 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S3: Biodistribution of cytokine fusion molecules in tumor-bearing mice.

2026

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3Supplementary Figure S10 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S10: In vitro and in vivo activity of AB248 in cynomolgus monkey.

2026

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4Figure S6 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Psmd6 and Cs sequences in 1956 subclones.

2026

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5Table S4 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

mItgb1 peptides detected in the CV optimization experiments.

2026

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6Table S15 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Twenty-two I-Ab binding F244 neoantigens screened.

2026

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7Supplementary Figure S8 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S8: Differential expression by treatment.

2026

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8Figure S8 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

F244 neoantigen tetramer staining and neoantigen targeting vaccines in F244 bearing mice.

2026

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9Table S10 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Top 20 predicted H-2Kb restricted neoepitopes of 1956 sarcomas.

2026

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10Table S14 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Top 33 predicted F244 MHC-I neoepitopes.

2026

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11Supplementary Figure S9 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S9: scRNAseq analysis of MC38 tumors.

2026

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12Table S2 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Top 25 I-Ab binding 1956 neoantigens.

2026

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13Figure S1 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Optimal FAIMS CV(s) improve the identification of 8–12-mer H-2Kb- or H-2Db-restricted peptides.

2026

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14Figure S4 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Optimal FAIMS CV(s) improve the detection of T3 I-Ab restricted neoantigen mItgb1.

2026

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15Tables S6-S9 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Table S6: Identification of mLama4 from ICT-naive T3 tumors. Table S7: Identification of mLama4 from ICT-treated T3 tumors. Table S8: Identification of mItgb1 from sorted CD45+ T3 TILs. Table S9: Identification of I-Ab bound peptides from ICT-treated T3 tumors.

2026

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16Table S11 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Top 20 predicted H-2Db restricted neoepitopes of 1956 sarcomas.

2026

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17Supplementary Figure S5 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Figure S5: Anti-tumor activity of CD8-mIL2 in combination with anti-PD-1 in B16F10, 1956, MCA-205, and KP.mLama4 tumor models.

2026

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18Table S3 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

Optimal FAIMS CV(s) improve the coverage of I-Ab restricted peptides.

2026

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19Supplementary Table S2 from IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity

Kelly D. Moynihan,Manu P. Kumar,Hussein Sultan,Danielle C. Pappas,Terrence Park,S. Michael Chin,Paul Bessette,Ruth Y. Lan,Henry C. Nguyen,Nathan D. Mathewson,Irene Ni,Wei Chen,

Supplementary Table S2, Antibodies used in this study

2026

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20Figure S7 from Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry

Wei Meng,Yoshiko Takeuchi,Jeffrey P. Ward,Hussein Sultan,Cora D. Arthur,Elaine R. Mardis,Maxim N. Artyomov,Cheryl F. Lichti,Robert D. Schreiber

F244 MHC-I and -II neoantigen prediction and screens.

2026

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作者统计

合作学者

合作机构

D-Core

合作者
学生
导师

Cora Arthur

Cora Arthur合作论文数37

Maxim N. Artyomov合作论文数Department of Pathology and Immunology, Washington University School of Medicine34

Jeffrey P. Ward合作论文数Division of Oncology, John T. Milliken Department of Medicine, Washington University School of Medicine34

Hussein Sultan合作论文数Washington University in St. Louis33

Elaine R. Mardis合作论文数Departments of Pediatrics, College of Medicine, The Ohio State University;Institute for Genomic Medicine, Nationwide Children's Hospital30

Hj Mullereberhard

Hj Mullereberhard合作论文数26

J Michael White

J Michael White合作论文数25

Kathleen C F Sheehan

Kathleen C F Sheehan合作论文数23

Jack Bui合作论文数Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego22

Takeuchi Yoshiko合作论文数Natl Canc Ctr, Res Inst22

Gavin P. Dunn

Gavin P. Dunn合作论文数20

Emil Raphael Unanue合作论文数Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis20

Ton Schumacher合作论文数Department of Immunology, The Netherlands Cancer Institute;Leiden University Medical Center19

Kenneth Murphy合作论文数Division of Immunobiology, Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis;Howard Hughes Medical Institute18

Kcf Sheehan

Kcf Sheehan合作论文数17

Lichti Cheryl F

Lichti Cheryl F合作论文数Dept Med, Washington Univ17

Lloyd J. Old合作论文数Memorial Sloan-Kettering Cancer Center17

Uppaluri Ravindra

Uppaluri Ravindra合作论文数16

Wayne M. Yokoyama合作论文数Roy and Diana Vagelos Division of Biology & Biomedical Sciences, School of Medicine, Washington University in St. Louis;Division of Rheumatology, Department of Medicine, School of Medicine, Washington University in St. Louis;Howard Hughes Medical Institute16

Matthew Gubin合作论文数Departments of Surgery, University of Missouri15

Jasreet Hundal合作论文数Natera14

Kelly D. Moynihan合作论文数Koch Inst Integrat Canc Res, MIT14

Marco Colonna合作论文数Department of Pathology & Immunology, School of Medicine, Washington University in Saint Louis14

MA FARRAR

MA FARRAR合作论文数13

Mark J. Smyth合作论文数Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute12

Michael K. Pangburn

Michael K. Pangburn合作论文数12

William Vermi合作论文数Department of Pathology;University of Brescia;Department of Pathology, University of Brescia12

S. Michael Chin

S. Michael Chin合作论文数11

Irene Ni

Irene Ni合作论文数11

Henry T. Nguyen合作论文数Division of Plant Science and Technology, College of Agriculture, Food and Natural Resources, University of Missouri11

Antonio Celada合作论文数Institute of Research in Biomedicine, University of Barcelona11

Anand S. Dighe

Anand S. Dighe合作论文数Center for Immunology and Department of Pathology, Washington University School of Medicine11

Jessie Chen

Jessie Chen合作论文数10

Manu P. Kumar

Manu P. Kumar合作论文数10

Ruth Y. Lan

Ruth Y. Lan合作论文数10

Yik A. Yeung

Yik A. Yeung合作论文数10

Terrence Park

Terrence Park合作论文数10

Danielle Pappas

Danielle Pappas合作论文数10

Ivana Djuretic

Ivana Djuretic合作论文数10

Paul Bessette合作论文数10

Sindy Liao-Chan

Sindy Liao-Chan合作论文数10

Chan Szeman Ruby

Chan Szeman Ruby合作论文数10

Mathewson Nathan合作论文数10

William Gillanders合作论文数10

Michael S. Diamond合作论文数Division of Infectious Diseases, John T. Milliken Department of Medicine, School of Medicine, Washington University in St. Louis10

Marina Cella合作论文数Department of Pathology and Immunology, School of Medicine, Washington University in Saint Louis10

Kelsey A Toth

Kelsey A Toth合作论文数9

Carol A Nacy合作论文数9

J Calderon

J Calderon合作论文数9

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Hj Mullereberhard

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J Michael White

J Michael White

Kathleen C F Sheehan

Kathleen C F Sheehan

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