Background and Aims: Lipoprotein(a) (Lp[a]), which consists of a low-density lipoprotein (LDL) bound to apolipoprotein (apo)(a), is a robust genetic risk factors for cardiovascular diseases. Although both lipoproteins carry other proteins than apoB and apo(a), few studies performed hypothesis-free, direct comparisons of the proteome of Lp(a) and LDL. We aimed at comparing the Lp(a) and the LDL proteomes in healthy individuals.