Neural drug delivery by microprobes is considered to be one of the most promising methods for treating brain related diseases since the drug liquid can be directly infused into a specific brain region. However, this requires in turn knowledge on the liquid distribution during infusion. This work evaluates the liquid distribution in agarose gel of micro-fabricated silicon probes with two different outlet styles in comparison to a conventional stainless steel capillary. The optical liquid distributions for infusion rates of 0.2, 0.5, and 1.2 μL/min are determined in a special experimental setup which allows in parallel the measurement of pressure and flow during infusion. Flexible fluidic interfacing to the silicon probes is achieved by small o-rings for easy interchangeability. Since the actual pressure and flow conditions at the outlets of the inserted microprobes cannot be directly measured, a system model of the experimental setup is derived which allows to determine these values. Information on the predominant liquid distributions for the different probe types and infusion rates is qualitatively provided. Finally, actual pressure and flow conditions as well as backflow heights are exemplary presented for an infusion rate of 0.2 μL/min.