Background & Objectives: Postoperative sore throat, cough, nausea, apnea and laryngospasm are common complications of intubation by endotracheal tube (ETT) in pediatrics. Laryngeal mask airway (LMA) is a supraglottic device used as alternative equipment for ETT in order to decrease the complications. Objective: to compare the incidence of postoperative sore throat after LMA with ETT in pediatrics. Materials & Methods: Seventy six patients between 2-12 years old with ASA class I-II who underwent cochlear implant surgery were enrolled and randomly divided in to two groups including ETT or LMA for airway management. The incidence of complications including sore throat, apnea, vomiting, laryngospasm, post operative cough, intra and post operative arrhythmia and the influence of these equipments on O2 saturation,End tidal co2, airway pressure, hemodynamic changes during operation were compared. Wong-Baker facial grimace scale was used to evaluate the severity of pain. Results: The rate of post operative sore throat and laryngospasm in ETT group was significantly higher than LMA group (p=0. 002, 0.011; respectively). Apnea and vomiting were not significantly different. Rate of post operative cough, incidence of intra and post operative arrhythmia were not significantly different between two groups. Mean arterial pressure, peak airway pressure, end tidal CO2, and Oxygen saturation during operation which measured continuously had not significantly different between two groups. Conclusion: LMA significantly decreases the rate of post operative sore throat and laryngospasm in pediatric. However, the rates of apnea, Oxygen saturation, and nausea were similar in both groups. Application of LMA for airway management is appropriate alternative to ETT in pediatric. Disclosure of Interest: None declared

Background & Objectives: Difficult to intubate (DTI) is a real challenge to anesthesiologists. Early prediction of DI is life-saving in order to equipments preparation. Objective: To determine the sensitivity and specificity of DTI detection by measuring flexion and extension of neck Materials & Methods: 190 patients with ASA class I,II candidate for elective surgery under general anesthesia with endotracheal intubation enrolled in the study. Prior to surgery range of neck extension and flexion were measured by Clinometer at sit and supine position. DTI was also measured using Cormack & Lehane score as a gold standard. The findings were compared between DTI patients and normal cases. To determine a cut-off point for flexion and extension clinometers scores were compared to Cormack & Lehane scores. Results: The range of flexion was not significantly different between DTI (66.71±9.80) and control patients (66.84±10.87) degrees (p=0.54). Degrees of extension was significantly lower in DTI group (37.14±9.60) compare to control group (42.76±13.88) (p=0.02). The accuracy of flexion and extension measurement to detect DTI was 49.9% and 62.2%; respectively. ROC curve analysis showed cut-off value of 65.5 for flexion and 37.5 degrees for extension had the best sensitivity and specificity for predicting DTI. Conclusion: Measuring neck extension degree has better sensitivity than neck flexion to detect difficult to intubation. Disclosure of Interest: None declared

Background: There are many reports on delayed emergence from anesthesia in the elderly due to propofol, but there are few reports that have considered the differences due to age at the time of induction. In this report, we conducted a study of the time taken to reach a hypnotic state subsequent to propofol bolus administration, after dividing the cases by dosage and age. Method: Taking as subjects 100 patients from ASA Evaluation I-II, we conducted a study on the Propofol dosage for anesthesia induction and BIS values. We measured the time (t50, seconds) until the BIS value reached 50 subsequent to Propofol administration, divided the subjects into four groups: those 70 years of age or older with Propofol dosages of 2 mg/kg (I-P2) and 1.5mg/kg (I-P1.5), and those below 70 years of age with P dosages of 2 mg/kg (II-P2) and 1.5 mg/kg (II-P1.5), and we then performed a comparative study. Results: In a comparison between I-P2 and II-P2, a significant difference (p , 0.0001) in t50, at 64}10 versus 51}11 seconds, was observed. Moreover, in a comparison between I-P1.5 and II-P1.5, t50 was 63}17 versus 54}18 seconds (p 1⁄4 0.2368). For the correlation coefficient between age and BIS50, a significant correlation was observed at a P dosage of 2 mg/kg of 0.557 (p , 0.0001), but no significant correlation was observed at 1.5 mg/kg of 0.217 (p 1⁄4 0.3015). Conclusions: Regarding delays in the time for anesthesia induction due to propofol at an advanced age, we have already published with respect to the possibility of a drop in sensitivity to anesthetic drugs due to advancing age. In addition, from these results, the delay in the time for anesthesia induction at a Propofol dosage of 2 mg/kg is obvious, but at a Propofol dosage of 1.5 mg/kg, between the two groups, no significant difference was observed in t50. This is because a Propofol dosage of 1.5 mg/kg has a wide range of t50 values regardless of age, even with young subjects, many cases requiring time have been observed. From the above, at a Propofol dosage of 1.5 mg/kg, the dosage was found to be too small to obtain an adequate level of hypnosis for young subjects. Paper No: 117.00

The aim of study was determine the effect of ultra-rapid opiate detoxification (UROD) on the presence or absence of withdrawal syndrome in a group of patients with opiate dependency. In this study, withdrawal syndrome of 173 patients with opiate addiction was evaluated before and after UROD using the Objective Opioid Withdrawal Scale. Hence, each patient was observed for 5 minutes before UROD and at different hours afterward to observe any withdrawal sign. The most prevalent withdrawal sign before UROD was anxiety. Restlessness was the most prevalent finding at 1, 3, and 6 hours. After 12 hours, yawning was reported as the most prevalent finding in 39 participants. Anxiety was reported as the most prevalent finding in 61 participants after 24 hours. Patients with opioid dependency who underwent UROD showed the highest rate of withdrawal symptoms at one hour after anesthesia. Most of these symptoms subsided after 24 hours. UROD can be applied for detoxification of patients with opioid dependency with safety.