In this article, we synthesized and characterized thiazolidine-appended silane, TZDVS (thiazolidine silane), as an efficient UV-visible chemo-sensor for the detection of Ni(II). TZDVS was characterized using various spectroscopic techniques, including NMR (1H, 13C), FT-IR spectroscopy, and mass spectrometry. The limit of detection (LOD) for Ni(II) was determined to be 6.7 x 10-9 M, with an association constant (Ka) of 0.0630 x 106 M-1. Job's plot analysis indicated a 1:1 metal-to-ligand binding stoichiometry. Density functional theory (DFT) analysis provided theoretical insights into the complexation of TZDVS with Ni(II), while FT-IR confirmed the formation of the TZDVS-Ni(II) complex experimentally. Thermogravimetric analysis (TGA) confirmed the high thermal stability of TZDVS. Moreover, TZDVS exhibited notable anticancer (against HeLa cells) and antibacterial properties (against Staphylococcus aureus and Bacillus subtilis). Molecular docking studies with the protein (PDB ID: 3RCD) revealed a favorable binding score of -7.13 kcal/mol-1, and real sample analysis disclosed its high potency to detect Ni(II) ions.

We here report an extensive study on the development of highly facile, selective and sensitive colorimetric probes adsorbed on rutile titanium nanoparticles (Ti NPs) for cysteine detection using interactive transition metals. In the presence of Fe(III), cysteine was able to induce the aggregation of synthesized nanoparticles thereby resulting in selective chemosensing observed by absorbance and fluorescence measurements. Cysteine/Fe+3complex showing ferredoxin (in blood) like activity and sensing by synthesized probes owe biological applicability. The reported probe has limit of detection comes out to be 2 mu M which shows the interaction tendency of cysteine. Furthermore, a remarkable feature of this work is that it involves a simple technique exhibiting high colorimetric sensitivity also for human blood.

This paper synthesizes triazole-attached 2-aminofluorene-based organosilane for sensing Fe 3+ ion using UV-Vis and fluorescence. Probe 6a 's inhibitory effect on the leishmania protein was studied. DFT explained 6a 's complexation with Fe 3+ ion.

The present study aims to produce nanocomposites of silica based organosilane as sensitive and selective fluorescent sensor for the recognition of 2,4 dichlorophenoxyacetic acid (2,4-D). Hydrazone tethered triazole functionalized organosilane has been synthesized by the condensation reaction of 4-hydroxybenzaldehyde and phenyl hydrazine followed by Cu(I) catalysed cycloaddition of azide with alkyne. The prepared compound has been further grafted over silica surface and the synthesized materials were characterized by FT-IR, NMR (1H and 13C), XRD, mass spectrometry and FE-SEM spectral analyses. The prepared organosilane and its HSNPs have been utilized as an effective emission probe for the selective detection of 2,4 D with good linear relationship in the range of 0-160 μM and 0-115 μM and LOD value of 46 nM and 13.5 nM respectively. In the presence of other active species, the sensor shows minimal interference while the comparison with the previously reported techniques suggests it to be more desirable for the sensitive and selective detection of 2,4 D. Further, the real sample application for detection of 2,4 D was analyzed in field water and the HSNPs based sensing system gave recovery percentage of above 98 %.

The present article includes the generation of aromatic Schiff base tethered organosilatranes via two step synthetic pathways starting from anthracene-10-carbaldehyde and 1H-indole-3-carbaldehyde. The synthesis was achieved by employing condensation reaction followed by transesterification methodology. The prepared organosilatranes containing aromatic schiff based ligands were structurally authenticated using spectroscopic techniques such as FT-IR, NMR and mass analysis. The prepared compounds were also scrutinized for in silico physiochemical properties via Molininspiration and ADMET software and the results revealed their good biological potential for drug discovery.

The increasing demand for the development of sustainable strategies to utilize and process agro-industrial residues paves new paths for exploring innovative approaches in this area. Biotechnology based microbial transformations provide efficient, low cost and sustainable approaches for the production of value added products. The use of organic rich residues opens new avenues for the production of enzymes, pigments, biofuels, bioactive compounds, biopolymers etc. with vast industrial and therapeutic applications. Innovative technologies like strain improvement, enzyme immobilization, genome editing, morphological engineering, ultrasound/supercritical fluid/pulse electric field extraction, etc. can be employed. These will be helpful in achieving significant improvement in qualitative and quantitative parameters of the finished products. The global trend for the valorisation of biowaste has boosted the commercialization of these products which has transformed the markets by providing new investment opportunities. The upstream processing of raw materials using microbes poses a limitation in terms of product development and recovery which can be overcome by modifying the bioreactor design, physiological parameters or employing alternate technologies which will be discussed in this review. The other problems related to the processes include product stability, industrial applicability and cost competitiveness which needs to be addressed. This review comprehensively discusses the recent progress, avenues and challenges in the approaches aimed at valorisation of agro-industrial wastes along with possible opportunities in the bioeconomy.

This work embodies the derivatization of functional organic fragments with triethoxysilyl motif to afford organotriazole silanes (5a-5e) using copper-catalyzed alkyne azide cycloaddition reaction under strictly anhydrous conditions. Furthermore, when compound Se was employed for the sensorial aptitude towards wide spectrum of transition metal ions, UV-Vis absorption analysis substantiates the selective binding with Fe2+ and Cu2+ ions. This sensor unveils unassailable binding ability, high sensitive and selectivity in semi aqueous media. LOD values for recognition of Fe2+ and Cu2+ ions were estimated to be 0.11 mu M and 0.12 mu M respectively and on the basis of the Job's plot, the feasible binding approach of the receptor with these ions have also been proposed.

The present article is about the synthesis of new family of pyrimidine based triazole linked organosilanes using Cu (I) catalyzed azide-alkyne click silylation reaction. The synthesized products have been well characterized by various spectroscopic techniques and they were further exploited for their use as receptor for the detection of Cu-2 + ion. The photophysical studies revealed that the organosilanes possess high sensitivity towards Cu2+ ion. Furthermore, the binding with the Cu2+ ion was af fi rmed using stern volmer equation. Interestingly, the limit of detection and the binding constant (K-sv) were in the range of 1.13.4 x 10(-7) M and 3.277.47 x 10(5) respectively. This makes the present work favourable in the branch of detection of heavy metal ion with lower detection limit without the need of any high priced technique. (C) 2020 Elsevier B.V. All rights reserved.

Provoked by multifarious applicability of nitrogen heterocycles and hypervalent silicon analogues in drug designing, we attempted the synthesis and structural characterization of a family of heterocyclic appended Organosilatranes tethered with an azomethine linkage by employing a three-step preparation route and carried out introspection into their prospective bioactivities. Using MOLINSPIRATION and ADMET toolkits, pharmacokinetic profiles of the designed scaffolds were investigated and the results showed their potential as promising drug candidates. The article also assesses the antioxidant potential and cytotoxicity property of the synthesized organosilatranes, which are required is to prevent the oxidative stress in the body formed of reactive species. It was observed that compounds 10-12 with methyl substituents on the atrane rings can be the best pretenders for radical scavenging activity while the cytotoxicity evaluation revealed that the compounds 7, 8 and 10 are least toxic of all examined organosilatranes.

A new series of ester appended organosilatranes (5a-f) were developed for the specific and selective detection of Cu2+, Hg2+ and Pb2+ and were well characterized by various spectroscopic techniques. The newly synthesized silatranes (5a-f) were appraised for heavy metal ion binding properties using UV-vis and photoluminescent spectra. In addition the stern volmer plot confirmed the quenching phenomenon on addition of Cu2+, Hg2+ and Pb2+. Interestingly, the detection limit of 5a-f with Cu2+, 5b with Hg2+ and 5d with Pb2+ is 1.07-3.56 mu M, 1.43 and 1.65 respectively. In a nutshell, the present article provides the cost-effective and promising platform for detection of these ions.

The research on biological synthesized nanoparticles and its applications in all fields ranging from pharmaceutical to electronics have opened new avenues in this area. The present study was aimed at the biological synthesis of silver nanoparticles using bacterial isolate from metal contaminated sites. The preliminary characterization of silver nanoparticles (AgNPs) was carried out using U.V-Visible spectroscopy. The antibacterial activities of the nanoparticles were checked against some pathogenic strains viz. Aeromonas liquefaciens and E. coli. Clear zone of inhibitions against test strains confirmed good antimicrobial activity of nano-suspensions. The present studies involve the bacterial growth study, minimum inhibitory concentration (MIC), and cytoplasmic leakage analysis followed by study of the effect of nanoparticles on water purification. The obtained results concluded that Ag-NPs exhibit excellent bactericidal effect towards test trains and hold promising potential towards purification of water sample.

Disproportionation reactions between (CF3CH2O)(3)GeNHC6H5-nFn and TiCl4 in petroleum ether (40-60 degrees C) at 0 degrees to -10 degrees C give (CF3CH2O)(2) Ge(NHC6H5 F-n(n))center dot(2)2TiCl(4) and (CF3CH2O)Ge(NHC6H5 F-n(n))center dot(3) 2TiCl(4) adducts. However, complete disproportionation of (CF3CH2O)(3)Ge( NHC6H5-nFn) (n = 1,2) occurs at -55 to -60 degrees C to give Ge(NHC6H5-nFn)center dot(4)3TiCl(4). These complexes give double adducts on reactions with CH3NO2 and CH3CN. All the products are characterized by elemental analyses and IR, H-1, and F-19 NMR spectroscopy. A comparative disproportionation of the germanamines and analogous silanamines is discussed.

Si(NHC6H4F-o)4 · 3TiCl4(1) has been obtained from the disproportionation of (CF3CH2O)3SiNHC6H4F-o and TiCl4 in petroleum ether (40–60 °C) at −10 °C. The analytical (elemental analysis, molar conductance) and spectral (i.r., 1H- and 19F-n.m.r.) data suggested that (1) behaves as [Si(NHC6H4F-o)4 · Ti2Cl7]+ [TiCl5]−. The presence of these ions has been confirmed by characterising the products of metathetical reactions of (1) with R4NX (R = Bu and Et; X = I and Br) and with AgNO3. The data suggest the presence of a new titanium cation [Ti2Cl7]+.

A germatrane with a Ge-NCS bond has been isolated and characterised by X-ray crystallography and molecular spectroscopy; Ge(NCS)(OCH2CH2)3N exhibits the shortest known Ge-N bond distance amongst germatranes and the first C-13-N-14 coupling [J(C-13-N-14) = 21.0 Hz] in a five-co-ordinate germanium compound.

A hexacoordinated monomeric silicon(IV) complex, (acac)2Si(NCS)2 [where acac = (CH3COCHCOCH3)-] was isolated and characterized by elemental analyses, IR, multinuclei (H-1, C-13 and Si-29) NMR spectral data. Initially the complex has the cis-structure in solution which changes to an equilibrium mixture (1.8:1) of cis and trans isomers at room temperature in 24 h.

Si(NHC6H4F-o)4 Æ 3TiCl4 (1) has been obtained from the disproportionation of (CF3CH2O)3SiNHC6H4F-o and TiCl4 in petroleum ether (40–60 C) at 10 C. The analytical (elemental analysis, molar conductance) and spectral (i.r., Hand F-n.m.r.) data suggested that (1) behaves as [Si(NHC6H4F-o)4 ÆTi2Cl7] + [TiCl5] . The presence of these ions has been confirmed by characterising the products of metathetical reactions of (1) with R4NX (R 1⁄4 Bu and Et; X 1⁄4 I and Br) and with AgNO3. The data suggest the presence of a new titanium cation [Ti2Cl7].