The present study assessed the effect of marjoram, propolis, and their combination against adenine induced chronic kidney disease (CKD) and renal dysfunction in male albino rats. Thirty-five rats weighing (200 ± 10 g) were divided into seven groups (n=5). The 1st control group, the 2nd adenine group (300 mg/kg), the 3rd marjoram group (100 mg/kg), the 4th propolis group (70 mg/kg), the 5th adenine + marjoram group, the 6th adenine + propolis group and the 7th adenine + marjoram + propolis group, all treatments were given orally for 30 consecutive days. The results showed that adenine treatment caused renal disorders with extensive tubulointerstitial fibrosis, tubular atrophy, crystal formation and marked vessel calcification in the kidney tissue associated with increasing the plasma renal biomarkers. The oxidative stress markers lipid peroxidation and protein carbonyl content were increased with a significant decrease in the activities of superoxide dismutase, catalase, and glutathione level. However, administration of marjoram and propolis separately or in combination improved kidney functions as they ameliorated the levels of renal function parameters and prevented oxidative stress. It can be concluded that marjoram and propolis in combination could cause an amazing improvement in the renal functions after adenine induced chronic renal failure and the histology of the kidney greatly recovered after the treatment with their combination. Thus, this surprise combination represents a new therapeutic strategy and gives good hope for a patient with CKD. *Correspondence to: Hani M Abdelsalam, Department of Zoology, Faculty of Science, Zagazig University, Egypt, Tel: 00201008051012; E-mail: Hani. abdelsalam@su.edu.eg