3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters (8a-h) showed high affinity for the norepinephrine transporter (NET). The most potent and selective compound was 3alpha-(3-fluoro-4-methylphenyl)nortropane-2beta-carboxylic acid methyl ester (8d), with a Ki of 0.43 nM at the NET and 21- and 55-fold selectivity relative to binding at the dopamine and serotonin transporters. The development of 8d makes available compounds selective for all three transporters from the same structural class.

The experienced Java developer's guide to persistence with JDO!Master JDO, the breakthrough technology for persistenting Java objects!Java Data Objects (JDO) streamlines development by providing Java-centric mechanisms for making objects persistent, and standard APIs for connecting application code with underlying persistent datastores. Core Java Data Objects is the definitive, comprehensive guide to JDO persistence for every experienced Java developer.Using realistic code examples, this book's expert authors cover creating, reading, updating, and deleting persistent objects; object lifecycles and state transitions; JDO classes and APIs; queries, architecture, security, and much more. They show how to integrate JDO with EJB, JTA, JCA, and other J2EE technologies; and introduce best practices for using JDO in both standalone programs and J2EE components.If you want to spend more time solving business problems and less time worrying about persistence, you need JDO. And you need the one book that'll help you make the most of JDO: Core Java Data Objects.Every Core Series book: DEMONSTRATES how to write commercial quality code FEATURES nontrivial programs and examples--no toy code! FOCUSES on the features and functions most important to real developers PROVIDES objective, unbiased coverage of cutting-edge technologies -- no hype!Core Java Data Objects delivers: Practical examples showing how JDO can be applied to existing applications Powerful insights for using JDO to architect new systems more effectively Step-by-step guidance for integrating JDO with other J2EE technologies Best practices for using JDO in real-world business environments

Preface. Section One: Web Services Overview. Service Oriented Architecture. Component-Based Services. Web Services Infrastructure. SOAP. WSDL. UDDI. ebXML. Section Two: JWSDP. JAXP. JAX-RPC. JAXM. JAXR. JAXB. Section Three: Transactions. Security. Practical Considerations. Futures. Appendixes: XML Schemas. JSTL. Index.

From the Publisher: This book is for professional Oracle database programmers who need a comprehensive roadmap of the new programming possibilities with Oracle 8i. On the other hand, if you are already developing with Java and XML this book will show you how to exploit PL/SQL and the enterprise features of Oracle 8i in optimally distributing your n-tier applications. Knowledge of the essentials of PL/SQL programming is required, and familiarity with Java would be useful. OVERVIEW: Oracle Corporation has broadened its development platform, integrating open standards such as Java and XML into the heart of the Oracle 8i database. This extended programming environment continues to exploit the qualities of scalability, reliability and efficiency of the world's most successful data management software, but at the same time it provides new challenges and opportunities to programmers. This book shows you how to develop enterprise PL/SQL applications exploiting Java and XML, and how technologies such as EJBs can be moved to the 8i database. You'll work through case studies using a mix of both familiar and unfamiliar tools and languages, showing you how the various programming approaches can enhance each other. Author Biography: The authors are a multi-author Wrox writing team of professional developers.