BACKGROUND:Cystic fibrosis (CF) patients present chronic cough as one of the main symptoms, which has an important effect on quality of life and social relations. Our goal was to validate the Spanish version of the Leicester Cough Questionnaire (LCQ) in a group of children and teenagers with CF.METHODS:After adapting to Spanish by standardized translation and retro-translation methodology, a sample of 58 stable CF patients from 7 to 18 years were recruited from three CF specialized centers in Spain. The questionnaire was administered twice; the second administration (LCQ2) was performed between 2-4 weeks later than the first one (LCQ1), in order to analyse the reliability and validity of the Spanish version. To correlate results with health related quality of life (HRQoL) we used the Cystic Fibrosis Questionnaire-Revised (CFQ-R).RESULTS:Population was composed by 62% male, age 11.7 ± 3.1 years and body mass index (BMI) 19 ± 3 kg/m(2). Total scores from LCQ were: LCQ1 19 (17.75-21) vs LCQ2 19 (16-21) (P=.199). Cronbach's Alpha coefficient was 0.83 for the LCQtotal and for each specific domain was: 0.82 LCQphysical; 0.74 LCQpsychological and 0.62 LCQsocial. Intraclass correlation coefficient was: 0.69 LCQphysical; 0.59 LCQpsychological; 0.45 LCQsocial and 0.71 LCQtotal (good reliability). Relations with CFQ-R showed moderated and significant results: for the LCQtotal: respiratory symptom domain r = 0,51 (P<.001) and physical capacity domain r = 0,62 (P<.05).CONCLUSION:The Spanish version of the Leicester Cough Questionnaire is reliable and valid for children and adolescents with CF and it has good relations with health related quality of life in this population.

Patients with cystic fibrosis (CF) are characterized by an abnormal ventilation response that limits the exercise capacity. Exercise training increases exercise capacity, decreases dyspnea and improves health-related quality of life in CF. Adherence to pulmonary rehabilitation programs is a key factor to guarantee optimal benefits and a difficult goal in this population.The aim of this study was to determine the physiological response during three Nintendo Wii (TM) video game activities (VGA) candidates to be used as training modalities in patients with CF.Method: 24 CF patients (age 12.6 +/- 3.7 years; BMI 18.8 +/- 2.9 kg m(-2); FEV1 93.8 +/- 18.8 %pred) were included.All participants performed, on two separate days, 3 different VGA: 1) Wii Fit Plus (Wii-Fit); 2) Wii Active (Wii-Acti), and 3) Wii Family Trainer (Wii-Train), in random order during 5 min. The obtained results were compared with the 6-min walk test (6MWT). The physiological variables [oxygen uptake (VO2), minute ventilation (V-E), and heart rate (HR)] were recorded using a portable metabolic analyzer.Results: During all VGA and 6MWT, VO2 reached a plateau from the 3rd min. Compared with the 6MWT (1024.2 +/- 282.2 mL m(-1)), Wii-Acti (1232.2 +/- 427.2 mL m(-1)) and Wii-Train (1252.6 +/- 360.2 mL m(-1)) reached higher VO2 levels during the last 3 min (p < 0.0001 in both cases), while Wii-Fit (553.8 +/- 113..2 mL m(-1)) reached significantly lower levels of VO2 (p < 0.001). Similar effects were seen for the ventilatory volume (VE). No differences in dyspnea and oxygen saturation were seen between the different modalities. All patients were compliant with all three Wii (TM) modalities.Conclusion: Active video game are well tolerated by patients with CF. All the modalities evaluated imposed a constant load but were associated with different physiological responses reflecting the different intensities imposed. Wii-Acti and Wii-Train impose a significantly high metabolic demand comparable to the 6MWT. Further research is needed to evaluate the effects of VGA as a training program to increase exercise capacity for CF patients. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Cystic Fibrosis (CF) is a chronic respiratory disease with a multisystemic involvement resulting in peripheral muscle fatigue. There are specific questionnaires that assess physical activity fatigue in children, Children Sport Fatigue Questionnaire (CSFQ) and Short Fatigue Questionnaire (SFQ). Objective: To validate the Spanish version of both questionnaires in healthy sportive children and to measure the sensitivity of both tools on children with CF that follow regular physical activity. Methodology: After the questionnaires translation and retro-translation, they were applied in 44 healthy sportive children twice. Sensitivity was measured in 20 children with CF and the results were compared with the Cystic Fibrosis Questionnaire Revised (CFQ-R). Results: Healthy children: age (12±2.6 years), BMI (19±2.7 kg/m2). Cronbach index showed good consistency, 0.86 to 0.78, CSFQ and SFQ and intraclass correlation coefficient showed: 0.85 and 0.83, CSFQ and SFQ, respectively. CF children: age (13±3.8 years), BMI (18±2.7 kg/m2). Significant correlations were obtained between CFQ-R and CSFQ: Physical 0.76, Body 0.66 and Role 0.85 for CFQ-R14+; Digestive 0.34 and Treatment 0.33 for CFQ-R Child. Correlations between CFQ-R and SFQ: Physical 0.53 and Role 0.54 for CFQ-R14+, and Treatment 0.40 for CFQ-R Child. Conclusion: The CSFQ and SFQ questionnaires are valid and reliable for assessing the fatigue caused by physical activity and being suitable for use in CF children that follow regular physical activity such us pulmonary rehabilitation. Sponsored by: Proyecto AVANZA, TSI-020110-2009-431. Ministerio de Industria Turismo y Comercio, Spain.