The GOST-21147 encryption implementation on graphics processing units is suggested. The approach for organizing the computation process on the GPU is described. Some realizations of basic operations for ciphering algorithm are suggested for Direct3D and OpenGL graphics API. The results of computational experiments on different GPU and CPU are given.

Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical enterprise and outlines the specific technologies used at various stages of drug development. With contributions from leaders in academia, information technology, and the pharmaceutical industry, each chapter illustrates how a particular area of biological science can benefit from the tools of informatics. The book first looks at intelligent automation, neurally based computational tools, and pharmacodynamic (PD) biomarkers. It then reviews a variety of novel technologies and approaches presently used in drug discovery at Johnson & Johnson. The text also describes how informatics can advance antibody technology and drug development for oncology. After focusing on forward genetic and reverse genetic strategies to identify relevant target genes for drug discovery, the book explains proteomic expression profiling and explores the application of laser microdissection in transcriptomics. Taking a systematic approach, this volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities.

This paper presents the results of a quantitative determination of the composition of final phosphorus-containing products (PO, PO2, HOPO, and HOPO2) from the destruction of the organophosphorus compounds trimethyl phosphate (TMP) and dimethyl methylphosphonate (DMMP) in premixed hydrogen–oxygen flames. The flames were stabilized on a flat burner at 47 Torr and probed using molecular beam mass spectrometric techniques. Quantitative analysis of these species is difficult, due to problems with mass spectrometric calibrations. Also these compounds are unstable under normal conditions and are not readily available. To solve this problem a material balance equation for the element phosphorus has been used to analyze the results in stoichiometric, rich, and lean flames, doped with different amounts of TMP and DMMP. A system of linear nondegenerate material balance equations was solved using the Singular Value Decomposition (SVD) algorithm. The calculated calibration coefficients for the phosphorus species have allowed their mole fractions to be derived. How the concentrations of PO, PO2, HOPO, and HOPO2 depend on the initial concentrations of DMMP or TMP and on the mixture’s composition has been studied. The measurements are compared to the results of thermochemical equilibrium calculations.

Molecular beam mass-spectrometry was used to study the structure of a premixed H-2/O-2/Ar (0.26/0.13/0.61) flame with and without additives (0.1-1.1% DMMP) stabilized on a flat-flame burner at 43-80 Torr (burner temperature 95 degrees C). The behavior of DMMP in the flame has been studied. Mass spectra of samples taken from flames, and intensity profiles of peaks 18 (H-2 O), 32 (O-2), 40(Ar), 47(PO), 63(PO2), 64 (HOPO), 80, 94, 110, 124(DMMP) amu have been measured as a function of the distance from the burner surface to the sampling probe using a quadrupole mass-spectrometer and electron impact ionization at 12.1-21.6 eV with a spread of electron energy +/- 0.25 eV. Intensity profiles of masses 110, 94, 80 pass through a maximum. This shows that the species responsible for these masses are intermediates. PO(CH3)OCH3(OH), P-2(OCH3) are possible intermediates. The profile of the temperature in the flame has been determined by using a Pt-PtRh(10%) thermocouple covered by Ceramobond 569. The effect of promotion on the H-2/O-2/Ar flame by the additive DMMP has been observed. The possible detailed chemical mechanism of the destruction of DMMP is presented.