A case of immature presacral teratoma in an adult female presenting in pregnancy is described. She remains free of disease 12 months following treatment with a combination of chemotherapy, radiotherapy, and surgery. Serum alpha-fetoprotein levels appeared to correlate more with tumor "aggression" than with tumor growth.

LOPES, A.; PEARSON, S. E.; MOR-YOSEF, S.; IRELAND, D.; MONAGHAN, J. M. Author Information

Between August 1985 and November 1988, 475 laser cone biopsies were performed at the Regional Gynaecological Oncology Unit in Gateshead. Of these, 332 were performed for abnormal cervical cytology and unsatisfactory colposcopy. The negative cone rate in this group was 34%. In those with cytological abnormalities up to and including mild dyskaryosis the figure was 64% and there were no cases of invasive disease. In this group the authors have reconsidered the criteria for cone biopsy and suggested biopsy of the visible ectocervical lesion combined with endocervical curettage or brushing. Those with negative histology or cytological abnormalities less than moderate dyskaryosis should be managed conservatively.

Summary. Over a period of 8 years and 6 months, 1979–1988, 4222 women were treated with laser ablation for cervical intraepithelial neoplasia (CIN) with or without papillomavirus infection of the cervix. Of 3738 patients followed up, nine werc diagnosed as having invasive cancers of the cervix, four of which were microinvasive. Tt is stressed that each woman treated with laser must have frequent, long‐term cytological follow‐up.