Objective: To complete the preparation of the electronic version of C-BCT, verifying the criterion validity of the electronic version of C-BCT. Methods: 747 healthy subjects and 139 schizophrenics completed the electronic version of C-BCT and MCCB. To measure psychotic symptoms and severity, patients with schizophrenia completed the PANSS scale. Mean, standard deviation, percentage, etc. were used to describe demographic variables. One-way analysis of variance and independent sample t-test were used to compare differences between groups. MCCB as a calibration tool, criterion validity was examined using Pearson product moment correlations. Results: In the equivalence analysis of the healthy group, all tests have good calibration validity (p < 0.01). SC and TMT-A showed moderate correlation (r- value ranged from 0.572 to 0.651, p < 0.01), DS showed a weak correlation(r = 0.373, p < 0.01), CPT showed a weak correlation (r- value ranged from 0.219 to 0.444, p < 0.01), the comprehensive scores of the two sets of cognitive tools showed a strong correlation (r = 0.739, p < 0.01). In the equivalence analysis of the patient group, TMT-A and SC showed strong correlation (r- value ranged from 0.754 to 0.803, p < 0.01), DS showed a weak correlation (r = 0.381, p < 0.01), the cognitive tools comprehensive score was significantly strong correlation (r = 0.755, p < 0.01), there was no correlation between CPT(p > 0.05). In the healthy group, there was a correlation between the scores of each subtest of the electronic version of C-BCT and the comprehensive scores of the two cognition tools, (r- value ranged from 0.261 to 0.824, p < 0.01). In the patient group, there was a correlation between the scores of each subtest and the comprehensive scores of the two tools,(r- value ranged from 0.266 to 0.778, p < 0.01). Conclusion: The electronic version of C-BCT has been compiled. The electronic version of the C-BCT performs well in overall calibration validity and could be used to assess the cognitive function of schizophrenia.

BACKGROUND:The aim of the study was to investigate the empirical validity of the Chinese Brief Cognitive Test (C-BCT) and examine the correlation between cognitive symptoms and functional outcomes in people with schizophrenia. METHODS:Patients with schizophrenia (n = 145) together with 723 healthy controls underwent testing with C-BCT and MATRICS Consensus Cognitive Battery (MCCB). Clinical staff measured Positive and Negative Syndrome Scale (PANSS) and Personal and Social Performance (PSP) Scale for patients. One-way analysis of covariance was conducted to compare cognitive performance across groups. The correlation between C-BCT performance and PANSS and PSP was examined using the Pearson product moment correlation. The Global Deficit Score (GDS) was used to identify the severity of cognitive impairment. The generalized linear model was used to analyze the effects of age, sex and education. RESULTS:The four scales of C-BCT alongside composite scaled score (Css) demonstrated statistical differences between groups with partial eta squared scores between 0.049 and 0.171. Composite scaled score was weakly correlated with each scale of the PANSS (r-value ranged from -0.242 to -0.190), and weakly correlated with PSP. In addition to Digit Span Task, scales of C-BCT had different correlations with PANSS and PSP. There were differences in GDS among patients with different employment status (p < .05). 55.9% of the patient sample had been identified as cognitive impaired using C-BCT. CONCLUSIONS:The C-BCT exhibits good empirical validity in Chinese patients with schizophrenia. Information processing speed, executive function, attention/vigilance, and overall cognitive performance were differently related to clinical symptoms and social function. HIGHLIGHTS:Cognitive impairment is one of the core symptoms and dimensions of schizophrenia.The Chinese Brief Cognitive Test (C-BCT) is a simplified cognitive assessment tool based on the Chinese cultural environment.The C-BCT has good empirical validity in Chinese patients with schizophrenia, and can evaluate neurocognition in Chinese patients with schizophrenia in a shorter time.The C-BCT may be helpful for clinicians and researcher because of its convenience and efficiency.

Background Emotional blunting is prevalent in patients with mood disorders and adversely affects the overall treatment outcome. The Oxford Depression Questionnaire is a validated psychometric instrument for assessing emotional blunting. We aimed to evaluate the reliability and validity of the Chinese version of the ODQ (ODQ) in Chinese patients with mood disorders. Methods 136 mood disorders patients and 95 healthy control participants were recruited at the First Affiliated Hospital of Zhejiang University, School of Medicine. Patients were assessed using the ODQ, Beck Depression Inventory-II (BDI-II), and Montgomery-Asberg Depression Rating Scale (MADRS). Internal consistency reliability and test-retest reliability were analyzed. Confirmatory factor analysis and correlation analysis were used to evaluate construct and convergent validity. Results A total of 136 patients with mood disorders and 95 healthy controls participated in this study. Cronbach α values were 0.928 (ODQ-20) and 0.945 (ODQ-26). Test-retest reliability coefficients were 0.798 (ODQ-20) and 0.836 (ODQ-26) (p<0.05); intraclass correlation coefficient values were 0.777 (ODQ-20) and 0.781 (ODQ-26) (p<0.01). The score of ODQ was positively correlated with BDI-II and MADRS (r=0.326~0.719, 0.235~0.537, p<0.01). The differences in the ODQ scores between the patient and control groups were statistically significant. Conclusion The reliability, structural validity, and criterion validity of the ODQ applied to patients with mood disorders meet the psychometric requirements, and the scale can be used to assess emotional blunting in Chinese patients with mood disorders.

The aim of this study was to develop a brief version of cognitive assessment test for evaluating the efficacy of treatments targeting cognitive impairments in Chinese schizophrenia patients, to examine its reliability, and establish normative data. Stratified according to age, gender, and educational level, healthy adult subjects were recruited from fifteen institutions in seven administrative regions of China and 723 valid samples were obtained, of which 50 were retested. Generalized Linear Models were conducted to analyze the effects of age, sex, and education. There was no significant difference between genders, while significant effects were demonstrated respectively among age and education on the normative data of C-BCT. The Cronbach α of C-BCT is 0.75, and the test-retest reliability (ICC) ranged from 0.62 to 0.76. Normative data of C-BCT were generated by gender, age and education, and the effects of these demographic factors were analyzed. It revealed good internal consistency and test-retest reliability of C-BCT.