Es besteht eine lineare, negative Beziehung zwischen der Puls-Transit-Zeit (PTZ) und dem Blutdruck (BD). Die vorliegende Studie untersucht die Validität der PTZ-Blutdruckmessung unter positiver Überdruckbeatmung (PAP).

Angiograms of cardiac transplant (HTx) recipients were to be evaluated in a ring experiment and a joint consensus on criteria of angiographic evaluation of coronary arteries of HTx patients was to be reached. Twenty-four coronary angiograms from 11 hospitals were circulated. One hundred eighty-eight blinded evaluations were returned. A joint evaluation by six experienced cardiologists was used as reference standard and a consensus evaluation form was developed. Significant lesions (stenosis 75%, 50% in the left main coronary artery) were diagnosed in 10/23 abnormal coronary angiograms (41.7%). Interventional revascularization was recommended in 8/10 (80%). In 21 coronary angiograms distal pruning was found and in 11/21 (52.4%) cases with distal pruning occlusion of at least one peripheral vessel was detected. The best kappa value (0.7) was found for the presence of at least one clinically significant stenosis. Agreement on the site and grade of local stenosis was much less. Some agreement on remodeling was found in assessing diffuse narrowing in the LCA (kappa=0.371, P<0.001). The kappa value for peripheral obliteration was 0.331 (P=0.001). Angiographic evaluation of cardiac allograft vasculopathy, particularly of diffuse and peripheral disease and remodeling, needs standardization. This should be performed in a downward compatible improvement process.

2 Institute for Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Ruhr-University of Bochum Abstract Due to the antiproliferative effect based on randomized trials, intracoronary brachytherapy is the gold standard therapy for the treatment of in-stent-restenosis. Patients with diabetes mellitus have a higher risk of recurrent restenosis than non-diabetics for non-stented or stented coronary lesions. In this study 176 patients with long in- stent restenosis treated with beta-radiation (strontium/yttrium and phosphorus) were examined. 44 (25%) of them were diabetics. The morphology of the treated coronary lesion did not differ between diabetics and non-diabetics. At 6 months follow-up the angiographic binary restenosis and the target vessel reintervention rate were similar in both groups (19.2% vs. 20.3% and 11.6% vs. 11.4% respectively). Although a randomized trial is missing, these data and the subgroup analysis of the brachytherapy studies suggest that in proliferative diabetic lesions the added (higher) risk of recurrent restenosis is neutralized by radiation therapy. J Kardiol 2003; 10:328-30.