Introduction:- The association between acute pancreatitis and pregnan cy is a rare condition, with an estimated incidence of 1.6 per 10,000 pregnancies. Establishing the diagnosis remains challenging and requires a combination of biological and radiological investigations, followed by prompt and appropriate management. Maternal prognosis is generally favorable, whereas fetal complications are mainly related to preterm delivery and acute fetal distress. Materials and Methods:-This retrospective study was conducted over a five-year period (2019-2023) in the Department of Obstetrics and Gynecology II at the University Hospital of Fez, Morocco. The study included a cohort of 24 pregnant women diagnosed with acute pancreatitis during pregnancy.

Struma ovarii tumor is a subtype of an ovarian teratoma and is composed entirely or predominantly of thyroid tissue and containing variable-sized follicles with colloid material. To qualify as a struma ovarii tumors more than 50% of the tumor should be composed of thyroid tissue. (1) Approximately 5-8% of cases can show symptoms or signs of thyrotoxicosis. (2) We report the case of a single 42-year-old woman admitted with pelvic pain associated with a mass. Radiologic examination revealed an adnexal tumor with great abundance ascites and no signs of metastasis. The patient underwent surgical treatment, which confirmed the presence of thyroid tissue in the left ovary, suggestive of Struma ovari tumor. The clinical and radiologic data are nonspecific. Histological examination is required for the diagnosis and is based on a biopsy or surgical specimen. (3) During the review period, a number of papers were published reporting series of patients with malignant ovarian germ cell tumors and describing the increasingly successful worldwide trend observed in treatment of such patients. Publications dealing solely with the successful management of patients with pure dysgerminoma, using surgery followed by chemotherapy which is less likely to affect fertility compared with radiation therapy. (4) The aim of this case is to highlight this exceptional histological type, which first requires an appropriate diagnostic strategy to rule out metastatic involvement from a primary thyroid tumor before confirming the diagnosis of struma ovarii.

Introduction:-Juvenile fibroadenoma is a rare benign fibroepithelial breast tumor characterized by rapid growth and large size, causing significant breast asymmetry mainly affecting adolescents. Its diagnosis may be challenging due to similarities with phyllodes tumors. Patient and observation:-We report the case of a 15-year-old girl with a family history of breast neoplasia who presented with a rapidly enlarging right breast mass. Physical examination revealed a firm, well-circumscribed, mobile mass measuring approximately 100 97mm. Breast ultrasonography demonstrated a large, homogeneous hypoechoic lesion classified as BI - RADS 4. Histopathological examination confir med the diagnosis of juvenile fibroadenoma. The patient underwent breast-conserving surgical excision by enucleation.

Pregnancy is an extraordinary experience, but it can come with its share of discomforts. Abdominal pain is a common concern for many pregnant women. While some discomfort may be normal, it is essential to understand the different types of abdominal pain and know when they may indicate a more serious problem. Abdominal pain during pregnancy refers to any discomfort or pain felt in the stomach or lower abdomen. It is a common symptom that can range in intensity from mild to severe. Abdominal pain during pregnancy can be obstetric, gynaecological, urinary or related to the digestive tract. Some types of pain are normal during pregnancy, while others require urgent treatment. When rarity complicates diagnosis, we report a very rare and exceptional case in pregnant women, pregnancy-related intestinal ischaemia, a rare emergency with maternal and foetal implications.

Diaphragmatic dome hernia (DCH) is a malformation of the diaphragm characterized by an embryonic defect of one (or both) diaphragmatic dome(s) The diagnosis is most often made during an antenatal screening ultrasound In the case of an isolated form, prenatal evaluation of the postnatal prognosis of children with diaphragmatic dome hernia (DDH) is necessary and is currently more accurate thanks to prognostic factors: LHR, position of the liver and total lung volume.Although the prognosis has improved over the last 20 years thanks to prenatal diagnosis, advances in surgery and management in neonatal intensive care, some children still develop complications, especially those with a severe form of the disease and/or the orifice in the diaphragm is in the right side. Methodology: We present a case of right CDH, right CDH overall with a poorer prognosis than left hernias, and through this case we present the methods of antenatal evaluation, prognostic factors, the main developments in surgical management, immediate postnatal management or long-term monitoring and the evolution of recommendations.

Pheochromocytoma is a rare, potentially lethal tumor that can be revealed by pregnancy, often mimicking a clinical picture of pre-eclampsia. We report the case of a pheochromocytoma that occurred in the 1st trimester, presenting with episodes of arterial hypertension (AHT). Treatment consisted of preoperative medical preparation followed by surgery. The maternal and fetal outcome was favorable. The occurrence of pheochromocytoma during pregnancy poses a problem in both diagnosis and blood pressure control. The therapeutic strategy depends on the gestational age, the maternal-fetal outcome (retention), and the response to medical treatment.

Paget's disease of the nipple (PDN) is a rare and often misdiagnosed condition characterized by the infiltration of adenocarcinoma cells into the nipple epidermis. It poses substantial diagnostic and therapeutic challenges due to its similarity to benign dermatological conditions and its association with in situ or invasive carcinoma. This case study presents a rare and clinically challenging instance of occult breast cancer associated with Paget's disease of the nipple. Occult breast cancers are often not detectable through standard imaging methods, such as mammograms or ultrasounds, and may only be identified after symptoms appear or through more invasive diagnostic techniques. Paget’s disease, a form of breast cancer that affects the skin of the nipple and areola, can be particularly difficult to diagnose early, as its symptoms—such as itching, redness, or discharge—can often mimic benign dermatological conditions. In many cases, Paget’s disease is associated with an underlying invasive breast cancer that is not immediately apparent, making early detection and intervention critical. This case highlights the diagnostic journey of a patient presenting with atypical nipple symptoms, ultimately revealing an occult breast cancer linked to Paget’s disease. Through this case, we aim to emphasize the importance of a thorough clinical evaluation and multi-disciplinary approach to diagnosis, as well as the significance of early recognition in improving patient outcomes.

Supernumerary breast tissue is a rare congenital anomaly that typically arises along the "milk line," which extends from the armpit to the groin. Though often benign, supernumerary breasts can be a site for malignancy, including invasive breast carcinoma. This case report describes the diagnosis and management of a patient who developed invasive breast carcinoma in her supernumerary axillary breast tissue, highlighting the importance of early detection and thorough investigation of any breast-related abnormalities, even in accessory tissue.

Measles is the most contagious vaccine-preventable viral disease. It spreads endemically and epidemically, with a peak incidence in spring. Transmission occurs mainly by air, through inhalation of infected respiratory secretions. Rubella during pregnancy, particularly during the first trimester, can cause miscarriage, fetal death, stillbirth, or congenital malformations, called congenital rubella syndrome (CRS). Measles during pregnancy exposes the patient to the risk of maternal pulmonary complications, early miscarriage, and threatened preterm delivery. The aim of our study is to analyze maternal complications, particularly respiratory and cardiac involvement, as well as fetal complications.

Background: Bilateral breast cancer (BBC) with discordant immunohistochemical (IHC) profiles is uncommon but presents significant challenges in diagnosis and treatment. When tumors in each breast exhibit distinct receptor status—such as triple-negative in one and hormone receptor-positive or HER2-positive in the other—treatment decisions become complex. Methods: We retrospectively analyzed five patients diagnosed between 2020 and 2024 with synchronous bilateral breast cancer exhibiting discordant IHC profiles. Clinicopathological characteristics, treatment regimens, and outcomes were reviewed. Results: All five patients presented with distinct molecular subtypes between the two breasts. Combinations included triple-negative and luminal A, HER2-positive and luminal B, and other discordant patterns. All were managed with personalized treatment plans addressing each tumor's biology. Treatment included combinations of chemotherapy, endocrine therapy, HER2-targeted therapy, and surgery. All patients completed treatment with no evidence of distant recurrence at the time of last follow-up. Conclusion: Discordant BBC highlights the importance of individualized treatment strategies and tumor board-based decision-making. Therapeutic planning should be guided by the most aggressive tumor phenotype, while ensuring comprehensive care for both malignancies.

L’utérus didelphe est une malformation utérine rare, caractérisée par la présence de deux cornes utérines et de deux cols. Le vagin peut être cloisonné ou normal Cette malformation est souvent associée à un hémi-vagin borgne et se présente avec une hématométrie et un hématocolpos à la ménarche, Le diagnostic est posé par échographie pelvienne complétée par résonnance magnétique Nous rapportons un cas d’un utérus didelphe diagnostiqué à l’âge de 23 ans au cours d’une césarienne chez une patiente primipare , sans antécédent pathologique , et nous souhaitons a travers ce cas et une revue de littérature mettre le point sur les aspects épidémiologiques, cliniques, embryologiques, anatomopathologiques, et thérapeutiques de cette malformation utérine.

La môle hydatiforme partielle (MHP) fait partie des maladies trophoblastiques gestationnelles. Appelée également môle embryonnée, il s’agit d’un œuf humain pathologique comportant des villosités en transformation vésiculaire, mais conservant une forme placentaire reconnaissable et une cavité amniotique avec un fœtus. La circonstance diagnostique la plus commune étant le tableau d’avortement spontané au premier trimestre. Rarement les môles partielles persistent au-delà du premier trimestre et sont alors source de complications maternelles et fœtales et de confusion diagnostique. L’origine génétique des MHP correspond à une conception triploïde avec un lot chromosomique supplémentaire d’origine paternelle. La coexistence d’un fœtus de caryotype normal avec une MHP est une situation exceptionnelle. Nous rapportons un cas rare de grossesse molaire partielle avec fœtus vivant polymalformé à 16 semaines d’aménorrhée (SA) chez une femme âgée de 24 ans .

Management of adnexal masses during pregnancy can be challenging for the patient and clinician. The specter of a possible malignant tumor may influence the decision to intervene rather than the expected management. The etiologies of ovarian masses vary depending on the age of the parturient, and therefore, benign entities such as functional ovarian cysts, benign cystic teratomas, and serous cystadenomas predominate. In cases of malignancy, these are generally germ cell tumors and borderline, low-grade ovarian tumors. Ultrasound is the primary modality used to detect ovarian masses and assess the risk of malignancy. Morphological criteria identify benign cysts more precisely than malignant tumors. Tumor markers are mainly used to monitor disease status after treatment rather than to establish the diagnosis of ovarian tumor due to lack of specificity, as several markers can be elevated by pregnancy itself (e.g. , CA-125, β-hCG). We report the cases of 2 patients who consulted the emergency room in a context of pelvic pain during pregnancy whose clinical examination aimed first to eliminate an emergency, notably a torsion of the adnexa, then to explore using ultrasound the etiology and characterize the objectified ovarian mass. The care is specific during pregnancy. Expectant management is recommended for most pregnant patients with asymptomatic, unsuspicious cystic ovarian masses. Surgical intervention during pregnancy is indicated for large and/or symptomatic tumors and those that appear highly suspicious for malignancy on imaging tests. The extent of surgery depends on the intraoperative diagnosis of a benign or malignant tumor. Conservative surgery is most often performed. More aggressive surgery is indicated for ovarian malignancies, including surgical staging. Although rarely necessary, chemotherapy has been used during pregnancy with minimal fetal toxicity in patients with advanced ovarian cancer, in which the risk of maternal mortality outweighs fetal consequences.

Leiomyomas of the uterus are the most common pelvic tumors, occurring in nearly 70% of 45-year-old women. This case report presents a multiparous woman who presented with an intracervical myoma that remained undiagnosed prenatally and during pregnancy (with no antenatal checkups). The vaginal delivery was uneventful. The patient presented on day 15 of post-partum with a large sub mucosa fibroid which prolapsed out of the introitus. A myomectomy was performed by twisting and rotation via the vagina, without complications.

Occult breast cancer is a breast cancer that can often be revealed by axillary lymph node metastasis without a primary breast lesion. Initially, the absence of a breast lesion was just clinical, but this definition has now been broadened to include the negativity of signs on mammography and ultrasound. management of patients with occult breast cancer is non-standardized and varied, ranging from simple surveillance to radical or conservative surgery, radiotherapy or systemic treatment. However, there is no consensus on the optimal management of these patients. This type of cancer is usually detected by axillary adenopathy. We report a case of a non-routine occult breast cancer, detected after adenectomy of a left suprasternal adenopathy and not by axillary lymphadenectomy. Our case showed other locations of occult breast cancer, other than axillary adenopathies, which remain the usual site of this type of cancer, illustrating that its natural history remains unclear. Although there were variations in the management of our patient, given her particular context, our case illustrates the need for individualized treatment.

Introduction/Background Ovarian cancer has a low incidence (10/100,000), but a high mortality rate explained by the fact that 75% of cases are diagnosed late due to non-specific clinical signs. To help with early diagnosis of ovarian cancer, new markers and scores were evaluated, such as HE4 and the ROMA score. The objective of our work is to evaluate the diagnostic value of HE4 and the ROMA score in order to make management recommendations and improve prognosis. Methodology Review of literature in French and English from 2009 to 2023 on the Pubmed, Cochrane and Embase databases. Results Dosage CA125 is recommended for the diagnosis of ovarian masses suspected of malignancy on imaging. HE4 dosage is recommended for the diagnosis of an indeterminate ovarian mass on imaging. Comparison of data on the sensitivity and specificity of serum CA125 and HE4 shows that CA125 has low specificity and sensitivity for first-line diagnosis, as its expression is notably absent in early stages (I and II) and in non-mucinous ovarian malignancies (serous, endometroid and clear cell cancers). HE4, on the other hand, is more sensitive and specific because it is expressed in all types of ovarian cancer, in the early stages and because it detects recurrence more quickly, given that its concentration increases 2 to 5 months before a clinical recurrence, making it an interesting marker for therapeutic follow-up and also for the differential diagnosis of endometriosis. The ROMA score evaluates the risk of malignancy by combining serum measurements of HE4, CA125 and menopausal status. It has an excellent and consistent negative predictive value (NPV) of 98 to 100%, giving a high assurance that a pelvic mass is benign if the ROMA score indicates a low risk. Conclusion Early diagnosis and detection of recurrence is the only way to improve prognosis in the short term. Disclosures The authors have no conflicts of interest to declare. There was no funding for this study.