Arthritis & RheumatismVolume 39, Issue 12 p. 2078-2079 ACR Slide CompetitionFree to Read Winners of the 1996 American College of Rheumatology slide competition and future plans for the clinical slide collection on the rheumatic diseases Eric L. Matteson, Eric L. MattesonSearch for more papers by this authorAmerican College of Rheumatology Audiovisual Aids Subcommittee, American College of Rheumatology Audiovisual Aids Subcommittee Members of the Audiovisual Aids Subcommittee of the Education Committee of the American College of Rheumatology: Eric L. Matteson, MD, Rochester, Minnesota (Chair); Dennis W. Boulware, MD, Birmingham, Alabama; Michael J. Maricic, MD, Tucson, Arizona; S. Ray Mitchell, MD, Washington, DC; Thomas A. Pressly, MD, Shreveport, Louisiana.Search for more papers by this author Eric L. Matteson, Eric L. MattesonSearch for more papers by this authorAmerican College of Rheumatology Audiovisual Aids Subcommittee, American College of Rheumatology Audiovisual Aids Subcommittee Members of the Audiovisual Aids Subcommittee of the Education Committee of the American College of Rheumatology: Eric L. Matteson, MD, Rochester, Minnesota (Chair); Dennis W. Boulware, MD, Birmingham, Alabama; Michael J. Maricic, MD, Tucson, Arizona; S. Ray Mitchell, MD, Washington, DC; Thomas A. Pressly, MD, Shreveport, Louisiana.Search for more papers by this author First published: December 1996 https://doi.org/10.1002/art.1780391220 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume39, Issue12December 1996Pages 2078-2079 RelatedInformation

Arthritis & RheumatismVolume 38, Issue 12 p. 1733-1734 ArticleFree to Read Winners of the 1995 ACR slide competition and future plans for the clinical slide collection on the rheumatic diseases Michael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorThe audiovisual aids subcommittee, The audiovisual aids subcommittee Members of the Audiovisual Aids Subcommittee of the Education Committee of the American College of RheumatologySearch for more papers by this authorDennis W. Boulware MD, Dennis W. Boulware MDSearch for more papers by this authorMichael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorDennis W. Boulware MD, Dennis W. Boulware MDSearch for more papers by this authorEric L. Matteson MD, Eric L. Matteson MDSearch for more papers by this authorS. Ray Mitchell MD, S. Ray Mitchell MDSearch for more papers by this authorThomas A. Pressly MD, Thomas A. Pressly MDSearch for more papers by this author Michael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorThe audiovisual aids subcommittee, The audiovisual aids subcommittee Members of the Audiovisual Aids Subcommittee of the Education Committee of the American College of RheumatologySearch for more papers by this authorDennis W. Boulware MD, Dennis W. Boulware MDSearch for more papers by this authorMichael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorDennis W. Boulware MD, Dennis W. Boulware MDSearch for more papers by this authorEric L. Matteson MD, Eric L. Matteson MDSearch for more papers by this authorS. Ray Mitchell MD, S. Ray Mitchell MDSearch for more papers by this authorThomas A. Pressly MD, Thomas A. Pressly MDSearch for more papers by this author First published: December 1995 https://doi.org/10.1002/art.1780381204 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume38, Issue12December 1995Pages 1733-1734 RelatedInformation

Arthritis & RheumatismVolume 37, Issue 12 p. 1816-1817 ArticleFree to Read WINNERS OF THE 1994 ACR SLIDE COMPETITION AND FUTURE PLANS FOR THE CLINICAL SLIDE COLLECTION ON THE RHEUMATIC DISEASES Michael J. Maricic, Michael J. MaricicSearch for more papers by this authorACR AUDIOVISUAL AIDS SUBCOMMITTEE, ACR AUDIOVISUAL AIDS SUBCOMMITTEE Members of the Audiovisual Aids Subcommittee of the Education Materials Committee of the Education Council of the American College of Rheumatology: Michael J. Maricic, MD, Chair; Sidney R. Block, MD; Eric L. Matteson, MD; S. Ray Mitchell, MD.Search for more papers by this author Michael J. Maricic, Michael J. MaricicSearch for more papers by this authorACR AUDIOVISUAL AIDS SUBCOMMITTEE, ACR AUDIOVISUAL AIDS SUBCOMMITTEE Members of the Audiovisual Aids Subcommittee of the Education Materials Committee of the Education Council of the American College of Rheumatology: Michael J. Maricic, MD, Chair; Sidney R. Block, MD; Eric L. Matteson, MD; S. Ray Mitchell, MD.Search for more papers by this author First published: December 1994 https://doi.org/10.1002/art.1780371217 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume37, Issue12December 1994Pages 1816-1817 RelatedInformation

Arthritis & RheumatismVolume 36, Issue 12 p. 1748-1750 ArticleFree to Read Winners of the 1993 acr slide competition and future plans for the clinical slide collection on the rheumatic diseases Michael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorACR AUDIOVISUAL AIDS SUBCOMMITTEE, ACR AUDIOVISUAL AIDS SUBCOMMITTEE Members of the Audiovisual Aids Subcommittee of the Education Materials Committee of the Education Council of the American College of Rheumatology: Michael J. Maricic, MD, Chair; Sidney R. Block, MD; Thomas M. Harrington, MD; Eric L. Matteson, MD; S. Ray Mitchell, MD.Search for more papers by this author Michael J. Maricic MD, Michael J. Maricic MDSearch for more papers by this authorACR AUDIOVISUAL AIDS SUBCOMMITTEE, ACR AUDIOVISUAL AIDS SUBCOMMITTEE Members of the Audiovisual Aids Subcommittee of the Education Materials Committee of the Education Council of the American College of Rheumatology: Michael J. Maricic, MD, Chair; Sidney R. Block, MD; Thomas M. Harrington, MD; Eric L. Matteson, MD; S. Ray Mitchell, MD.Search for more papers by this author First published: December 1993 https://doi.org/10.1002/art.1780361216 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume36, Issue12December 1993Pages 1748-1750 RelatedInformation

the rise of milk, we-encouraged the mothers to increase the number of feedings.6.We are aware of the limits of these data.The results of a similar study that we carried out in term infants at 6 days and at 32 days of age are now available (paper submitted for publication), and it appears that the observations and the conclusions made at 6 days of age remain relevant and are confirmed by the data obtained at 32 days of age.

Survival in systemic lupus erythamatosus (SLE) continues to improve because of better ancillary care, earlier diagnosis, and earlier treatment. However, infection remains a leading cause of morbidity and mortality in this disease Although corticosteroids and immunosuppressives increase the risk of opportunistic infection, the SLE patient is still most at risk from common bacterial pathogens. As the prototypic immune-complex disease, patients with active SLE have low circulating complement as well as a reticuloendothelial system (RES) saturated with immune complexes. It seems intuitive that SLE patients should be most at risk for organisms dependent for their removal on the RES or complement for opsonization or bacteriolysis. The current series presents four patients with SLE and disseminated neisseria infection and brings to 14 the number of patients in the literature with disseminated neisserial infection. They are typically young, female, with renal disease, and either congenital or acquired hypocomplementemia, and may present with all features of a lupus flare. Surprisingly, they are not all on corticosteroids or immunosuppressives and have some features that are unusual for non-SLE patients with these infections. There seems to be an over-representation of Nisseria meningitidis (despite potential reporting bias), and there ironically may be better tolerance with fewer fulminant complications in patients who have complement deficiencies. The best approach for the physician treating SLE is to immunize all SLE patients with available bacterial vaccines to N meningitidis and Streptococcus pneumonia, have a low threshold of suspicion for the diagnosis of disseminated neisserial or other encapsulated bacterial infection in the SLE patient who is sick, and to treat empirically with third generation cephalosporins after appropriate cultures.

A case of disseminated neisserial disease during pregnancy with good perinatal outcome is presented along with two examples of disseminated N. meningitidis from endocervical site. Upon close review, it is clear that the biological similarities of both N. gonorrhoeae and N. meningitidis may outweigh their differences. The two organisms may behave in clinically indistinguishable fashion and probably justify a more cautious approach to the clinical syndromes we have considered the inviolate domain of the gonococcus. The management of disseminated neisserial disease in pregnancy should include prompt empiric parenteral therapy while aggressive diagnostic confirmation of the organism is pursued. In addition, neonatal conjunctivitis caused by a Gram-negative diplococci should be treated parenterally until clinical response and identity of the organism is confirmed.

We examined the ability of human natural killer (NK) cells to modulate T cell-dependent mitogen-induced B cell responses. Highly purified NK cells inhibited the polyclonal antibody responses of autologous pokeweed mitogen (PWM)-stimulated unfractionated mononuclear cells in a reverse hemolytic plaque-forming cell (PFC) assay. Investigation of the possible mechanism(s) of the suppressor activity of NK cells revealed that lysis of mitogen-stimulated cells was unlikely. Chromium-51 release cytotoxicity assays of PWM-stimulated mononuclear cells did not demonstrate lysis by NK cells. Additionally, the monoclonal antibody 13.3, which abrogates NK cell cytolysis, did not reverse NK cell-dependent suppression of PFC formation. The putative lytic molecule elaborated by NK cells, NK cytotoxic factor, did not suppress B cell responses, further supporting a nonlytic inhibitory mechanism. That NK cell-derived lymphokines such as IFN-α, IFN-γ, or IL-2 were uninvolved in the down-regulation of B cells was corroborated by the failure of antibodies to these mediators to reverse the suppression. NK cells did not suppress PFC formation when T cells were replaced by supernatants from PWM-stimulated T cells; additionally, NK cells had no effect on the generation of these necessary T cell factors. However, the coculture of T cells with NK cells resulted in the induction of suppressor activity within the T cell population suggesting that this was the mechanism of NK cellmediated Suppression of B cell responses.