Suzanne E. Lapi

教授

Department of Radiology Heersink School of Medicine University of Alabama at Birmingham Department of Chemistry University of Alabama at Birmingham Cyclotron Facility and Radiochemistry Laboratory University of Alabama at Birmingham

4Papers / 论文

82Citations / 引用

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个人简介

Suzanne E. Lapi, Ph.D. is currently Vice Chair of Translational Research in the Department of Radiology, Professor with Tenure of Radiology and Chemistry and Cyclotron Facility Director. She is also a member of the O’Neal Comprehensive Cancer Centre and the UAB Alzheimer’s Disease Center. Her research interests are in the development and translation of new PET radionuclides and molecular imaging agents. In particular, she has an active program investigating 89Zr radiolabeled antibodies as molecular imaging agents in preclinical and clinical trials in oncology. Her other main area of research interest is in the development of new isotopes for PET imaging such as 45Ti and 43Sc.
Dr. Lapi has been continually funded with support from NIH, DOE, many foundations and industry partnerships. She has over 80 publications and is a member of the Board of Directors of the Society of Nuclear Medicine and Molecular Imaging. She has trained over 20 graduate students and postdoctoral fellows who overwhelming stay in the field of molecular imaging. She is also an active member of many initiatives with the International Atomic Energy Agency (IAEA).

教育经历

1995 – 2001 B.S. Simon Fraser University
2002 – 2003 M.S. Simon Fraser University
2003 – 2007 Ph.D. Simon Fraser University

工作经历

2007 – 2008 Postdoctoral Fellow UCSF Radiology and Biomedical Imaging
2018 – Present Vice Chair of Translational Research University of Alabama at Birmingham
2018 – Present Professor with Tenure University of Alabama at Birmingham
2017 – Present Division Director, University of Alabama at Birmingham
2015 – 2018 Associate Professor with Tenure University of Alabama at Birmingham
2015 – Present Cyclotron Facility Director University of Alabama at Birmingham School of Medicine
2014 – 2015 Associate Professor with tenure Washington University Radiology
2013 – 2015 Assistant Professor, Washington University
2012 – 2015 Adjunct Assistant Professor, Washington University
2012 – 2015 Assistant Professor, Washington University
2009 – 2014 Assistant Professor Washington University Radiology

全面呈现 [Suzanne E. Lapi] 的学术影响力

深度挖掘高质量成果与权威引用，让优秀看得见

研究兴趣

201720212023

论文（4）

专利

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1Optimized Methods for the Production of High-Purity203Pb Using Electroplated Thallium Targets

Shefali Saini,Jennifer L Bartels,Jean-Pierre K Appiah, Jason H Rider,Nicholas Baumhover,Michael K Schultz,Suzanne E Lapi

203Pb is a surrogate imaging match for 212Pb. This elementally matched pair is emerging as a suitable pair for imaging and targeted radionuclide therapy in cancer care. Because of the half-life (51.9 h) and low-energy γ-rays emitted, 203Pb is suitable for the development of diagnostic radiopharmaceuticals. The aim of this work was to optimize the production and separation of high-specific-activity 203Pb using electroplated thallium targets. We further investigated the radiochemistry optimization using a suitable chelator, tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and targeting vector, VMT-α-NET (lead-specific chelator conjugated to tyr3-octreotide via a polyethylene glycol linker). Methods: Targets were prepared by electroplating of natural or enriched (205Tl) thallium metal. Scanning electron microscopy was performed to determine the structure and elemental composition of electroplated targets. Targets were irradiated with 24-MeV protons with varying current and beam time to investigate target durability. 203Pb was purified from the thallium target material using an extraction resin (lead resin) column followed by a second column using a weak cation-exchange resin to elute the lead isotope as [203Pb]PbCl2 Inductively coupled plasma mass spectrometry studies were used to further characterize the separation for trace metal contaminants. Radiolabeling efficiency was also investigated for DO3A chelator and VMT-α-NET (a peptide-based targeting conjugate). Results: Electroplated targets were prepared at a high plating density of 76-114 mg/cm2 using a plating time of 5 h. A reproducible separation method was established with a final elution in HCl (400 μL, 1 M) suitable for radiolabeling. Greater than 90% recovery yields were achieved, with an average specific activity of 37.7 ± 5.4 GBq/μmol (1.1 ± 0.1 Ci/μmol). Conclusion: An efficient electroplating method was developed to prepare thallium targets suitable for cyclotron irradiation. A simple and fast separation method was developed for routine 203Pb production with high recovery yields and purity.

2023Journal of nuclear medicine official publication, Society of Nuclear Medicine（2023）引用：5

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2Production of Zr-89 Using Sputtered Yttrium Coin Targets

Stacy Lee Queern,Tolulope Aramide Aweda,Adriana Vidal Fernandes Massicano,Nicholas Ashby Clanton,Retta El Sayed,Jayden Andrew Sader,Alexander Zyuzin,Suzanne Elizabeth Lapi

An increasing interest in zirconium-89 (Zr-89) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for Zr-89 that provides this isotope with high radionuclidic purity and specific activity. We investigated the irradiation of yttrium sputtered niobium coins and compared the yields and separation efficiency to solid yttrium coins. The sputtered coins were irradiated with an incident beam energy of 17.5 MeV or 17.8 MeV providing a degraded transmitted energy through an aluminum degrader of 12.5 MeV or 12.8 MeV, respectively, with various currents to determine optimal cyclotron conditions for Zr-89 production. Dissolution of the solid yttrium coin took 2 h with 50 mL of 2 M HC1 and dissolution of the sputtered coin took 15-30 min with 4 mL of 2 M HCI. During the separation of Zr-89 from the solid yttrium coins, 77.9 +/- 11.2% of the activity was eluted off in an average of 73 mL of 1 M oxalic acid whereas for the sputtered coins, 91 +/- 6% was eluted off in an average of 1.2 mL of 1 M oxalic add with 100% radionuclidic purity. The effective specific activity determined via DFO-SCN titration from the sputtered coins was 108 7 mCi/pmol as compared to 20.3 mCi/pmol for the solid yttrium coin production. ICP-MS analysis of the yttrium coin and the sputtered coins showed 99.99% yttrium removed with 178 lag of yttrium in the final solution and 99.93-100% of yttrium removed with remaining range of 0-42 lag of yttrium in the final solution, respectively. The specific activity calculated for the solid coin and 3 different sputtered coins using the concentration of Zr found via ICP-MS was 140 +/- 2 mCi/pmol, 300 30 mCi/ punol, 410 +/- 60 mCi/pmol and 1719 5 mCi/pmol, respectively. Labeling yields of the Zr-89 produced via sputtered targets for Zr-89-DFO-trastuzumab were >98%. Overall, these results show the irradiation of yttrium sputtered niobium coins is a highly effective means for the production of Zr-89. (C) 2017 Elsevier Inc. All rights reserved.

2017NUCLEAR MEDICINE AND BIOLOGY（2017）引用：8

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3Production of Zr-89 Using Sputtered Yttrium Coin Targets 89zr Using Sputtered Yttrium Coin Targets.

Stacy Lee Queern,Tolulope Aramide Aweda,Adriana Vidal Fernandes Massicano,Nicholas Ashby Clanton,Retta El Sayed,Jayden Andrew Sader,Alexander Zyuzin,Suzanne Elizabeth Lapi

An increasing interest in zirconium-89 (89Zr) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for 89Zr that provides this isotope with high radionuclidic purity and specific activity. We investigated the irradiation of yttrium sputtered niobium coins and compared the yields and separation efficiency to solid yttrium coins. The sputtered coins were irradiated with an incident beam energy of 17.5MeV or 17.8MeV providing a degraded transmitted energy through an aluminum degrader of 12.5MeV or 12.8MeV, respectively, with various currents to determine optimal cyclotron conditions for 89Zr production. Dissolution of the solid yttrium coin took 2h with 50mL of 2M HCl and dissolution of the sputtered coin took 15-30min with 4mL of 2M HCl. During the separation of 89Zr from the solid yttrium coins, 77.9 ± 11.2% of the activity was eluted off in an average of 7.3mL of 1M oxalic acid whereas for the sputtered coins, 91 ± 6% was eluted off in an average of 1.2mL of 1M oxalic acid with 100% radionuclidic purity. The effective specific activity determined via DFO-SCN titration from the sputtered coins was 108±7mCi/μmol as compared to 20.3mCi/μmol for the solid yttrium coin production. ICP-MS analysis of the yttrium coin and the sputtered coins showed 99.99% yttrium removed with 178μg of yttrium in the final solution and 99.93-100% of yttrium removed with remaining range of 0-42μg of yttrium in the final solution, respectively. The specific activity calculated for the solid coin and 3 different sputtered coins using the concentration of Zr found via ICP-MS was 140±2mCi/μmol, 300±30mCi/μmol, 410±60mCi/μmol and 1719±5mCi/μmol, respectively. Labeling yields of the 89Zr produced via sputtered targets for 89Zr- DFO-trastuzumab were >98%. Overall, these results show the irradiation of yttrium sputtered niobium coins is a highly effective means for the production of 89Zr.

2017Nuclear medicine and biology（2017）引用：44

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4Production and evaluation of high specific activity 186Re: An isotope for radioimmunotherapy in cancer treatment

Suzanne Elizabeth Lapi

2007引用：25

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