Conventional caries management relies on mechanical excavation, which inevitably removes potentially remineralizable tissue. This study demonstrates that caries-affected dentin can regain structural and mechanical integrity without tissue removal through ion-mediated self-repair. Extracted human teeth with natural root caries were treated with silver diamine fluoride (S), glass ionomer cement (G), or their combination (SG), and stored in artificial saliva for up to 6 months. Specimens were evaluated using micro-computed tomography (micro-CT), synchrotron-based wide-angle X-ray scattering (WAXS), and nanoindentation. Micro-CT revealed a timedependent mineral gain in the SG group, while WAXS revealed fluorapatite-like and silver-substituted hydroxyapatite (HAp) phases, along with distinctive correlation peaks indicating ionic cross-linking at the dentin-GIC interface. Nanoindentation confirmed significant mechanical reinforcement after 6 months, with the highest nanohardness in the SG group. The results suggest that silver and fluoride ions from SDF were stabilized and gradually migrated through the GIC layer, promoting lattice reorganization and interfacial reinforcement within the underlying dentin. These findings provide mechanistic evidence that SDF beneath GIC facilitates selfrepair of demineralized dentin through sustained ionic migration and structural reorganization, combining antimicrobial action with ion-mediated structural reinforcement. This ion-mediated self-repair concept supports a non-cutting minimally invasive strategy that preserves carious dentin and enhances substrate resilience.

Objective: A retrospective study of 66 patients with oral squamous cell carcinoma was conducted, focusing on the outcomes and treatment-related adverse events of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia on metastatic lymph nodes. Methods: The superficial temporal and occipital arteries were catheterized. The treatment consisted of super-selective intra-arterial chemotherapy (docetaxel, 60 mg/m2; cisplatin, 150 mg/m2) and daily concurrent radiotherapy (60 Gy) combined with hyperthermia for 6 weeks. Hyperthermia was induced once or twice weekly for 50 min during chemoradiotherapy. Results: The 3-year locoregional control and overall survival rates were 82 % and 78 %, respectively. Treatment-related adverse events included grade 3 and 4 oral mucositis in 97 % of patients, radiation dermatitis in 50 %, and grade 1 and 2 neck skin burns in 59 % of patients. Conclusions: This combination therapy has led to good outcomes in patients with advanced oral cancer and lymph node metastases.

ObjectiveSuperselective intra-arterial chemoradiotherapy (IACRT) is a radical treatment performed to preserve function in patients with oral cancer. However, the characteristics of infectious complications in this patient population and the prognostic impact remain unclear.MethodsWe retrospectively reviewed 245 consecutive patients who underwent IACRT from 2008 to 2016. The characteristics of those who developed infectious complications during IACRT were compared with those who did not.ResultsOne hundred eighty-four infectious complications occurred during IACRT in 133/245 (54%) patients, including intra-arterial catheter site infection (19.0%, 2.7/1000 catheter-days), central line- and peripheral catheter-associated bloodstream infection (8.7%), febrile neutropenia (16.3%), pneumonia (8.7%), Clostridioides difficile infection (8.7%) and fever of unknown origin (26.6%). Multivariate regression analysis revealed that central venous catheter placement (adjusted odds ratio: 1.42) and Grade 3/4 neutropenia (adjusted odds ratio: 1.23) were significantly associated with infectious complications. Patients with infectious complications during IACRT had a worse prognosis than those without, with 5-year overall survival rates of 66.2% and 79.4%, respectively.ConclusionsInfectious complications during IACRT interrupt the course of cancer treatment, worsening prognosis. Thus, close monitoring and infection prevention measures are suggested to improve prognosis in patients with oral cancer undergoing IACRT.

BackgroundThe ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has changed cancer treatment. However, specific guidelines for patients with oral cancer and SARS-CoV-2 infection, especially for chemoradiation therapy (CRT), are lacking. Case PresentationWe report a case of a woman with oral squamous cell carcinoma diagnosed with SARS-CoV-2 nosocomial infection, although she had no COVID-19 symptoms, while undergoing superselective intra-arterial CRT. She received sotrovimab while continuing CRT and achieved a complete response. ConclusionThe general condition of the patient and the CRT regimen characteristics should be considered in the treatment of patients with COVID-19 and cancer.

Considering vessel deformation, endovascular navigation requires intraoperative geometric information. Mechanical intravascular ultrasound (IVUS) with an electromagnetic (EM) sensor can be used to reconstruct blood vessels with thin diameter. However, the integration design should be evaluated based on the factors affecting the reconstruction error. The interference between the mechanical IVUS and EM sensor was measured in different relative positions. Two designs of the integrated catheter were evaluated by measuring the reconstruction errors using a rigid vascular phantom. When the distance from the EM sensor to the field generator was 75 mm, the interference from mechanical IVUS to an EM sensor was negligible, with position and rotation errors less than 0.1 mm and 0.6°, respectively. The reconstructed vessel model for proximal IVUS transducer had a smooth surface but an inaccurate shape at large curvature of the vascular phantom. When the distance to the field generator was 175 mm, the error increased significantly. Placing the IVUS transducer on the proximal side of the EM sensor is superior in terms of interference reduction but inferior in terms of mechanical stability compared to a distal transducer. The distal side is preferred due to better mechanical stability during catheter manipulation at larger curvature. With this configuration, surface reconstruction errors less than 1.7 mm (with RMS 0.57 mm) were achieved when the distance to the field generator was less than 175 mm.

Purpose: We report a case of febrile infection-related epilepsy syndrome (FIRES) with a lesion in the splenium of the corpus callosum, and explore the pathophysiology by conducting a literature review.

Retrograde superselective intra-arterial chemoradiotherapy is a radical treatment for advanced oral cancer. The catheter tip is placed into tumor-feeding arteries—the lingual, facial, or maxillary arteries. The diameter of the tumor-feeding arteries newly bifurcated from the external carotid artery is crucial for determining the requirement of a catheter navigation system. This study aimed to measure the diameter and distribution of the tumor-feeding artery according to an objective protocol using 3D computed tomography angiography images reproducibly. Angiographic data of 20 noncatheterized carotid arteriesof 10 randomly selected patients were analyzed. We followed the external carotid artery to the entrance of each feeding artery to determine the center point where the artery diameter was measured. The diameter of the optimum circle measured at the adopted center point was taken as the diameter of each tumor-feeding artery. The diameters (mean ± standard deviation) were 3.5 ± 0.45, 2.9 ± 0.56, and 3.5 ± 0.56 mm for the maxillary, lingual, and facial arteries, respectively. The diameters of the maxillary and facial arteries were similar (p = 0.877), whereas the diameter of the lingual artery was smaller than that of the maxillary and facial arteries (p < 0.001). The findings of this study will be beneficial in determining the need of a new catheter navigation system and diameter of catheters to be used in the clinical practice. From the viewpoint of measurement automation and reproducibility, 3DCTA vessel measurement taken according to the proposed protocol was considered to be effective.

Autoimmune lymphoproliferative syndrome (ALPS) is a disease of lymphocyte homeostasis caused by FAS-mediated apoptotic pathway dysfunction and is characterized by non-malignant lymphoproliferation with an increased number of TCRαβ+CD4−CD8− double-negative T cells (αβDNTs). Conversely, RAS-associated leukoproliferative disease (RALD), which is caused by gain-of-functional somatic variants in KRAS or NRAS, is considered a group of diseases with a similar course. Herein, we present a 7-year-old Japanese female of RALD harboring NRAS variant that aggressively progressed to juvenile myelomonocytic leukemia (JMML) with increased αβDNTs. She eventually underwent hematopoietic cell transplantation due to acute respiratory distress which was caused by pulmonary infiltration of JMML blasts. In general, αβDNTs have been remarkably increased in ALPS; however, FAS pathway gene abnormalities were not observed in this case. This case with RALD had repeated shock/pre-shock episodes as the condition progressed. This shock was thought to be caused by the presence of a high number of αβDNTs. The αβDNTs observed in this case revealed high CCR4, CCR6, and CD45RO expressions, which were similar to Th17. These increased Th17-like αβDNTs have triggered the inflammation, resulting in the pathogenesis of shock, because Th17 secretes pro-inflammatory cytokines such as interleukin (IL)-17A and granulocyte-macrophage colony-stimulating factor. The presence of IL-17A-secreting αβDNTs has been reported in systemic lupus erythematosus (SLE) and Sjögren’s syndrome. The present case is complicated with SLE, suggesting the involvement of Th17-like αβDNTs in the disease pathogenesis. Examining the characteristics of αβDNTs in RALD, JMML, and ALPS may reveal the pathologies in these cases.

Hypertrophic pachymeningitis (HP) is a rare inflammatory disorder characterised by local or diffuse thickening of the cranial and spinal dura mater. HP occurs owing to idiopathic or secondary causes, including autoimmune disease, infection, and trauma. HP has mainly been reported in adults, with few reported cases in children. We encountered an 11-year-old boy with idiopathic HP who presented with chronic inflammation and daily occipital headache. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) helped us to diagnose him with HP. He was successfully treated with corticosteroids and azathioprine with no recurrence. We also conducted a literature review of childhood-onset HP and found only 16 cases, including our patient. Seven patients had idiopathic HP, and the remaining nine had secondary HP, including two with rheumatic disease. The most common clinical symptoms were headache (68.8%) and cranial nerve-related symptoms (68.8%). Inflammatory laboratory markers were elevated in 60% of patients with available data. Fifteen cases were diagnosed using Gd-enhanced MRI. The main initial treatment was steroids and/or immunosuppressants, to which 87.5% of patients responded. However, two patients with HP associated with trauma and neuroblastoma (12.5%) died, and seven patients (43.8%) had left cranial nerve-related sequelae. As the prognosis for childhood HP is poor, early diagnosis and treatment are essential. Children with headache, cranial nerve symptoms, and elevated inflammatory marker levels should be suspected of having HP and Gd-enhanced MRI should be considered.

Arthritis is one complication of Kawasaki disease (KD); however, the clinical features of arthritis in KD have not been well clarified. We retrospectively investigated the characteristics of persistent arthritis beyond the subacute phase of KD. In this cohort, 49 of 243 patients (20%) developed arthritis, with 33 patients (14%) experiencing persistent arthritis. Among these 33 patients, 31 (94%) had complete KD. Thirty (91%) were resistant to first intravenous immunoglobulin, and 15 (45%) required additional infliximab. Five patients (15%) developed coronary artery lesions, and 24 (73%) had oligoarthritis, mainly in large lower-extremity joints. Twenty-four patients (73%) complained of arthralgia. At arthritis onset, 16 patients (48%) presented with fever, including recurrent fever in 10 patients. Serum C-reactive protein concentration in patients with active arthritis significantly increased compared with after acute KD treatment (2.4 vs. 0.7 mg/dL, p < 0.001). Serum matrix metalloproteinase-3, a biomarker of arthritis, was significantly higher in patients with active arthritis than in remission (93.7 vs. 20.3 ng/mL, p < 0.001). Thirty (91%) and 14 (42%) patients, respectively, were treated with non-steroidal anti-inflammatory drugs and prednisolone, and they completely recovered. To summarize, persistent arthritis is a common complication in refractory KD, and adequate diagnosis and treatment are necessary.

Tracking the position and orientation of a 4F catheter ( ϕ 1.4 mm) is required in superselective intra-arterial chemotherapy (SSIAC). Tunneling magnetoresistance (TMR) sensors, which measure magnetic fields, are promising candidates because the size of the TMR sensor can be less than a few tenths of a millimeter. The purpose of this paper is to prove the feasibility of an EMT system utilizing TMR sensors as magnetometers. Three 1-axis TMR sensors (0.3 mm × 0.3 mm) were packaged on a flexible printed circuit board (PCB) together with an amplifier chip. The PCB was integrated into a 4F catheter. Six field generator coils driven by alternating current (AC) at different frequencies were used. Magnetic field measurement errors were evaluated to assess the effect of electromotive force (EMF) on TMR-based sensing by changing the coils’ driving frequencies. The tracking error was also evaluated. As a result, the feasibility of catheter navigation utilizing the EMT system was demonstrated. There was a positive correlation between the frequency and the magnetic field measurement error using the TMR sensor (R2 = 0.999). With magnetic field frequencies less than 603 Hz, the average position and orientation estimation error were 10.1 mm and 2.3 degree, respectively. Under ideal conditions, the average estimation error values were 0.9 mm and 0.3 degree, respectively. The position and orientation errors varied with frequency owing to the induced electromotive force. We should consider the effect of electromotive force on TMR sensor assemblies caused by alternating magnetic fields. An EMT system using TMR sensors was validated, although room for further improvement was identified.

ObjectiveSystemic juvenile idiopathic arthritis (sJIA) is characterized by fever, arthritis, rash, hepatosplenomegaly, and macrophage activation syndrome; however, its pathogenesis is still unclear. Elevated serum interleukin (IL)‐18 concentrations and decreased natural killer (NK) cell activity are characteristic of active disease; thus, we examined IL‐18 signaling in NK cells from sJIA.MethodsWe analyzed mitogen‐activated protein kinase (MAPK) p38 and nuclear factor κ light chain enhancer of activated B cells (NFκB) p65 phosphorylation in NK cells after in vitro recombinant IL‐18 (rIL‐18) stimulation in 31 patients with sJIA. Associations between clinical features, serum IL‐18, and phosphorylation intensity were analyzed. Furthermore, we investigated the effects of high IL‐18 concentrations on phosphorylation in NK cells.ResultsPatients were divided according to their disease activity: systemic features (n = 8), chronic arthritis (n = 7), remission on medication (n = 10), and remission off medication (n = 6). MAPK p38 and NFκB p65 phosphorylation intensity were the highest in healthy controls, followed by remission off medication, remission on medication (vs. control; MAPK p38, P < 0.01; NFκB p65, P < 0.05), chronic arthritis (P < 0.001, P < 0.001), and systemic features (P < 0.001, P < 0.001). The systemic features group showed a complete defect in phosphorylation. Serum IL‐18 was the highest in the systemic features group followed by chronic arthritis, remission on medication (P < 0.01), remission off medication (P < 0.01), and healthy controls (P < 0.01). Phosphorylation intensity was negatively correlated with serum IL‐18 (MAPK p38, r2 = 0.42; NFκB p65, r2 = 0.54). Furthermore, healthy control NK cells were cultured with rIL‐18; impaired phosphorylation was reproduced in vitro.ConclusionImpaired IL‐18 signaling in NK cells correlated with disease activity in sJIA. High serum IL‐18 exposure induces impaired MAPK and NFκB phosphorylation in NK cells.

The nosocomial transmission of severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2) in many medical settings has been widely reported. 1 The droplet and airborne transmission are regarded as major routes of the transmission of SARS-CoV-2. Nebulizer therapy is considered risky during the coronavirus disease 2019 (COVID-19) pandemic due to its production of droplets 2 ; however, droplet production by a nebulizer remains unclear. and colleagues in 1946 and The ;

Abstract The new disease concept of multisystem inflammatory syndrome in children (MIS-C), which is a systemic inflammatory syndrome with multiple organ involvement after SARS-CoV2 infection, was established in 2020. MIS-C is common in Hispanic and black children in Europe and North America, with few reports in East Asians. A significant portion of patients with MIS-C develop Kawasaki disease (KD)-like symptoms. Therefore, differential diagnosis is challenging, especially in East Asia, where KD is most prevalent. No Japanese cases have been reported in the literatures so far. We report a case of MIS-C in Japan with KD-like symptoms. A 9-year-old Japanese boy, who was infected with SARS-CoV2 1 month previously along with his family, was admitted to our hospital owing to fever for 6 d and erythema mainly in the groyne and pubic area. He also had conjunctivitis, strawberry tongue and diarrhoea. His laboratory findings were as follows: WBC, 12,840/µL (lymphocytes, 4%); CRP, 22.6 mg/dL, pro-calcitonin, 1.8 ng/mL (normal, <0.50 ng/mL); NT pro-BNP, 7627 pg/mL (<125 pg/mL); and troponin T, 0.14 ng/mL (<0.01 ng/mL). His cardiac function was normal. We initially diagnosed him with KD. His fever rapidly resolved with intravenous immunoglobulin (IVIG) and there were no coronary artery lesions. Desquamation of the fingers was observed later. Finally, a history of SARS-COV2 infection, his age, atypical skin rash, elevation of markers of inflammation and heart failure and lymphopenia suggested the diagnosis of MIS-C rather than KD. Differentiation between KD and MIS-C is necessary even in Japan, especially in patients with atypical features of KD.

The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to nosocomial infections in many medical settings [[1]Zhou Q. Gao Y. Wang X. Liu R. Du P. Wang X. et al.Nosocomial infections among patients with COVID-19, SARS and MERS: a rapid review and meta-analysis.Ann Transl Med. 2020; 8: 629https://doi.org/10.21037/atm-20-3324Crossref PubMed Google Scholar]. Consequently, there is a growing interest in protection against droplets and aerosols generated by medical procedures. In particular, dental treatment is a source of droplets and aerosols in the oral cavity that may contain SARS-CoV-2, and infection control measures during these procedures require special attention. Because SARS-CoV-2 RNA has been detected in environments where patients infected with coronavirus 2019 (COVID-19) have received dental treatment, analysis of aerosol dynamics in dental treatment facilities is crucial to provide safe dental care [[2]Akin H. Karabay O. Toptan H. Furuncuoglu H. Kaya G. Akin E.G. et al.Investigation of the presence of SARS CoV-2 in aerosol after dental treatment.Int Dent J. 2021; (S0020-6539(21)98-8. https://doi.org/10.1016/j.identj.2021.05.002)Crossref PubMed Scopus (9) Google Scholar]. High-speed rotary cutting instruments are commonly used in dentistry to grind teeth and bones and to adjust and remove dental restorations. An air turbine is a high-speed rotary cutting instrument that uses compressed air to drive a turbine rotor mounted in the head of the handpiece to rotate a cutting bar. The heat generated in the cutting area is cooled from the head to the cutting bar by a water jet. In this study, we used a high-speed camera to film the cutting of a human tooth with an air turbine and a laser beam. In addition to the cooling water, a portion of the compressed air was injected through a gap in the press-button chuck on the back of the turbine head, causing the surrounding water droplets to fly up at high speed. This study was approved by the Ethical Review Committee of Yokohama City University Hospital (approval number: B20100000), and the experiment was performed in a private room in the outpatient clinic of the Department of Dentistry, Oral and Maxillofacial Surgery and Orthodontics of Yokohama City University Hospital. An Osada fine joint head turbine (OFJ-TZL(P); Osada, Tokyo, Japan) was used with a rotation speed of 350,000 rpm and a cooling water flow rate of 60 mL/min. The cutting target was an extracted human molar. A red laser sheet (5 W, 638 nm wavelength; Katokoken Co. Ltd, Kanagawa, Japan) was irradiated at a distance of ∼75 cm from the tooth to be cut, perpendicular to the ground and passing through the tooth. Since SARS-CoV-2 is contained in droplets >2.5 μm in diameter, the water droplets could be visualized on the laser sheet [[3]Liu Y. Ning Z. Chen Y. Guo M. Liu Y. Gali N.K. et al.Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.Nature. 2020; 582: 557-560https://doi.org/10.1038/s41586-020-2271-3Crossref PubMed Scopus (1276) Google Scholar]. A summary of the system used is available at https://www.youtube.com/watch?v=8IH9RqJNoik. The images were captured using a high-speed camera (HX-7s, 10,000 frame/s; NAC Image Technology, Tokyo, Japan) that was set up perpendicular to the laser sheet and placed ∼75 cm from the tooth to be cut. Images of water droplets sprayed from the turbine head to cool the cutting area and of water droplets generated by the exhaust from the back of the turbine head were captured. The average vector of the droplets every 1000 frames (100 ms) was determined. The droplets coming from the back of the turbine head were at a high velocity of 4 m/s (Figure 1a). Such high-velocity droplets could be directly sprayed on to the face of the surgeon or caregiver or generate aerosols and float far away. SARS-CoV-2 infection may occur when virus particles contained in an aerosol are inhaled or when they adhere to mucous membranes [[4]van Doremalen N. Bushmaker T. Morris D.H. Holbrook M.G. Gamble A. Williamson B.N. et al.Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1.N Engl J Med. 2020; 382: 1564-1567https://doi.org/10.1056/NEJMc2004973Crossref PubMed Scopus (6347) Google Scholar,[5]Sommerstein R. Fux C.A. Vuichard-Gysin D. Abbas M. Marschall J. Balmelli C. et al.Risk of SARS-CoV-2 transmission by aerosols, the rational use of masks, and protection of healthcare workers from COVID-19.Antimicrob Resist Infect Control. 2020; 9: 100https://doi.org/10.1186/s13756-020-00763-0Crossref PubMed Scopus (157) Google Scholar]. The main risk factor for COVID-19 transmission is the total amount of virus to which healthcare workers are exposed [[6]Bianco F. Incollingo P. Grossi U. Gallo G. Preventing transmission among operating room staff during COVID-19 pandemic: the role of the Aerosol Box and other personal protective equipment.Updates Surg. 2020; 72: 907-910https://doi.org/10.1007/s13304-020-00818-2Crossref PubMed Scopus (29) Google Scholar]. Therefore, the World Health Organization has emphasized the need for enhanced personal protective equipment (PPE), and our findings confirm the importance of such equipment [[7]World Health OrganizationClinical management of COVID-19: interim guidance.2020https://apps.who.int/iris/bitstream/handle/10665/332196/WHO-2019-nCoV-clinical-2020.5-eng.pdfGoogle Scholar]. Even relatively large aerosols containing droplets of ∼100 μm in diameter can pose a risk of remaining airborne for about 5 min [[8]Wang C.C. Prather K.A. Sznitman J. Jimenez J.L. Lakdawala S.S. Tufekci Z. et al.Airborne transmission of respiratory viruses.Science. 2021; 373 (PMID: 34446582)eabd9149https://doi.org/10.1126/science.abd9149Crossref Scopus (441) Google Scholar]. In fact, many blood droplets are often found on face shields when a patient's tooth is split with a high-speed rotating cutting tool (Figure 1b). In conclusion, it is essential to wear enhanced PPE, including N95 mask and eye protection such as face shields and goggles, when performing dental treatment with an air turbine during an epidemic where the infectious particles can be spread by droplets, such as COVID-19. The authors would like to thank Enago (www.enago.jp) for the English language review. T. Ohya: study concept or design, data acquisition, analysis or interpretation of the data, and drafting/revising the manuscript. K. Nakagawa: data acquisition, analysis or interpretation of the data, and drafting/revising the manuscript. Y. Arai: data acquisition, analysis or interpretation of the data, and drafting/revising the manuscript. H. Kato: data acquisition, analysis or interpretation of the data, and drafting/revising the manuscript. None declared. This work was supported by JSPS KAKENHI Grant Number JP20H04553, Japan.

Superselective intraarterial infusion chemoradiotherapy is a modality of oral cancer therapy in which the artery feeding the tumor is catheterized. 3D information about the carotid artery is required to enable the surgeon to judge whether to advance, retract, or rotate the catheter. For this purpose, we proposed and conducted a model experiment to assess a new method of catheterization that applies a tracking system using registration with a monocular camera using the maxillary arch as the anatomical landmark. In this method, the preoperative 3D computer tomography angiographic image of the carotid artery that the catheter will be passed through is overlaid on the 2D video image. The mean TRE was 0.96 ± 0.36 mm and 0.88 ± 0.31 mm and 1.12 ± 0.46 mm when images were registered with the anterior and posterior teeth as the landmarks, respectively; the difference was not significant (p = 0.21). This tracking system that enables markerless registration simply by taking images of the maxillary anterior teeth with a single camera was convenient and effective for catheterization. In this study, we propose the new application of this tracking system and a novel method of catheterization for superselective intraarterial infusion chemoradiotherapy for oral cancer.

The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra‐arterial infusion chemotherapy concurrent with radiotherapy.

Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study. In the DIACRT group, 25 patients had late T2, and 20 patients had T3. A total of nine patients had late T2 and two had T3 in WIACRT (p = NS). In DIACRT, the treatment schedule consisted of intra-arterial chemotherapy (DOC, total 60 mg/m2; CDDP, total 150 mg/m2) and daily concurrent radiotherapy (RT) (total, 60 Gy). In WIACRT, the treatment schedule consisted of intra-arterial chemotherapy (CDDP, total 360 mg/m2) and daily concurrent RT (total, 60 Gy). Results: The median follow-up periods for DIACRT and WIACRT were 61 and 66 months, respectively. The five-year local control (LC) and overall survival (OS) rate were 94.5% and 89.6% for the DIACRT group, and 60.6% and 63.6% for the WIACRT group, respectively. The LC rate and OS of the DIACRT group were significantly higher than those of the WIACRT group. As regards toxicities, no treatment-related deaths were observed during the follow-up periods in both groups. Conclusions: DIACRT was found to be feasible and effective for patients with tongue cancer and could become a new treatment modality.