This paper reports a microfabricated triaxial capacitive force sensor. The sensor is fully encapsulated with inert and biocompatible glass (fused silica) material. The sensor comprises two glass plates, on which four capacitors are located. The sensor is intended for subdermal implantation in fingertips and palms and providing tactile sensing capabilities for patients with paralyzed hands. Additional electronic components, such as passives and IC chips, can also be integrated with the sensor in a hermetic glass package to achieve an implantable tactile sensing system. Through attachment to a human palm, the sensor has been shown to respond appropriately to typical hand actions, such as squeezing or picking up a bottle.

The sense of touch is critical to dexterous use of the hands and thus an essential component to efforts to restore hand function after amputation or paralysis. Prosthetic systems have focused on wearable tactile sensors. But wearable sensors are suboptimal for neuroprosthetic systems designed to reanimate a patient's own paralyzed hand. Here, we developed an implantable tactile sensing system intended for subdermal placement. The system is composed of a microfabricated capacitive force sensor, a custom integrated circuit supporting wireless powering and data transmission, and a laser-fused hermetic silica package. The miniature device was validated through simulations, benchtop testing, and ex vivo testing in a primate hand. The sensor implanted in the fingertip accurately measured skin forces with a resolution of 4.3 mN. The output from this novel sensor could be encoded in the brain with microstimulation to provide tactile feedback. More broadly, the materials, system design, and fabrication approach establish new foundational capabilities for various applications of implantable sensing systems.

The sense of touch is critical to dexterous use of the hands and thus an essential component of efforts to restore hand function after amputation or paralysis. Prosthetic systems have addressed this goal with wearable tactile sensors. However, such wearable sensors are suboptimal for neuroprosthetic systems designed to reanimate a patient’s own paralyzed hand. Here, we developed an implantable tactile sensing system intended for subdermal placement. The system is composed of a microfabricated capacitive pressure sensor, a custom integrated circuit supporting wireless powering and data transmission, and a laser-fused hermetic silica package. The miniature device was validated through simulations, benchtop assessment, and testing in a primate hand. The sensor implanted in the fingertip accurately measured applied skin forces with a resolution of 4.3 mN. The output from this novel sensor could be encoded in the brain with microstimulation to provide tactile feedback. More broadly, the materials, system design, and fabrication approach establish new foundational capabilities for various applications of implantable sensing systems.

This paper presents a computer-controlled multidirectional UV-LED (ultraviolet light-emitting diode) lithography system for three-dimensional (3-D) microfabrication, introducing the concept of CNC-lithography. The system comprises a switchable, movable UV-LED array as a light source and a motorized tilt-rotational sample holder, in which each system element is computer-controlled. This approach enables a relatively small size and overall portability of the system. The proposed system has two unique features; (1) the movable LED array improves the uniform UV light distribution over the substrate area; and (2) the switchable function of the LEDs is synchronized with the movement of the tilt-rotational sample holder, enabling the creation of 3-D patterns of substantial complexity. Unlike layer-by-layer additive approaches such as stereolithography, the CNC-lithography system can form fine shapes with no layering artifacts in a batch-compatible manner, at the expense of true arbitrariness of formable shape. When compared to conventional inclined lithography, CNC-lithography greatly increases ease of fabrication by eliminating multiple manual exposure steps and also enables the fabrication of new 3-D structures that would have been challenging to implement previously. Demonstration lithographic shapes, including a micro-'pipe,' a micro-'hi,' a micro-'Calla lily,' and a micro-'cyborg', are fabricated to illustrate the range of the process.