Corticotropin-releasing factor (CRF, nomenclature as agreed by the NC-IUPHAR subcommittee on Corticotropin-releasing Factor Receptors [34]) receptors are activated by the endogenous peptides corticotrophin-releasing hormone, a 41 amino-acid peptide, urocortin 1, 40 amino-acids, urocortin 2, 38 amino-acids and urocortin 3, 38 amino-acids. CRF1 and CRF2 receptors are activated non-selectively by CRH and UCN. CRF2 receptors are selectively activated by UCN2 and UCN3. Binding to CRF receptors can be conducted using radioligands [125I]Tyr0-CRF or [125I]Tyr0-sauvagine with Kd values of 0.1-0.4 nM. CRF1 and CRF2 receptors are non-selectively antagonized by α-helical CRF, D-Phe-CRF-(12-41) and astressin. CRF1 receptors are selectively antagonized by small molecules NBI27914, R121919, antalarmin, CP 154,526, CP 376,395. CRF2 receptors are selectively antagonized by antisauvagine and astressin 2B.
seiya miyamoto合作论文数506Bernard Le Foll合作论文数495
Michael M Morgan合作论文数489Klaus A. Miczek合作论文数478
Johannes Mosbacher合作论文数Nervous System Research, Novartis Pharma AG458
Ian P Stolerman合作论文数454
Harriet De Wit合作论文数Department of Psychiatry and Behavioral Neuroscience, University of Chicago;Human Behavioral Pharmacology Laboratory, University of Chicago450
Andrea Bari合作论文数Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge417Warren K. Bickel合作论文数416
Matthew I. Palmatier合作论文数Department of Psychology, University of Nebraska-Lincoln411
Stefan Leucht合作论文数Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München;Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich407
Peter Shizgal合作论文数Department of Psychology, Faculty of Arts and Science, Concordia University;Center for Studies in Behavioural Neurobiology, Concordia University406
Britta Hahn合作论文数University of Maryland School of Medicine, Maryland Psychiatric Research Center406Darren R. Christensen合作论文数405
Giovanni Hernandez合作论文数Douglas Mental Hlth Univ Inst405
Michael Thomas Bardo合作论文数Center for Drug Abuse Research Translation, University of Kentucky;Department of Psychology, College of Arts & Sciences, University of Kentucky387Annemarie Unger合作论文数383Gabriele Fischer合作论文数377MacDonald J. Christie合作论文数376
Martine Cador合作论文数374Rick A. Bevins合作论文数368
Celia Morgan合作论文数NIHR Exeter Biomedical Research Centre, University of Exeter368Bart Ellenbroek合作论文数359
Christof Baltes合作论文数358Josee E. Leysen合作论文数354Warren H. Meck合作论文数345Mohammed Shoaib合作论文数Department of Computer Science & Engineering;University of Engineering and Technology;Department of Computer Science & Engineering, University of Engineering and Technology341Thomas Mueggler合作论文数338Stephen C. Fowler合作论文数331Suzanne H. Mitchell合作论文数329
Markus Rudin合作论文数Institute for Biomedical Engineering, University of Zurich;Institute for Pharmacology and Toxicology, University of Zürich324
Joseph Zohar合作论文数Psychiatry and the Anxiety and Obsessive Compulsive Clinic, Sheba Medical Center;Tel Aviv University317
Alex Hofer合作论文数317Ronald F. Mucha合作论文数315Yogita Chudasama合作论文数314Steve Kohut合作论文数312Huaiyu Yang合作论文数311
Martín Cammarota合作论文数Centro de Memória;Instituto de Pesquisas Biomédicas;Av . Ipiranga;Centro de Memória, Instituto de Pesquisas Biomédicas311
Anthony L. Riley合作论文数Psychopharmacology Laboratory, American University309
Lia R. M. Bevilaqua合作论文数Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)309Andrew Young合作论文数308Jos Prickaerts合作论文数308Mary E. Cain合作论文数306Ennio Esposito合作论文数Laboratory of Neurophysiology, Consorzio Mario Negri Sud304R. Andrew Chambers合作论文数303Ashwini Padhi合作论文数302W. Wolfgang Fleischhacker合作论文数301Kim Wolff合作论文数297Iván Izquierdo合作论文数294
