The transitory and steady-state entanglement of a two-qubit XY Heisenberg magnetic spin system immersed in an external magnetic field are analyzed in terms of the entanglement measure of concurrence. The dependence of the system entanglement on coupling strength, decay rate, and applied magnetic field is numerically simulated for two distinct models of system evolution involving decoherence to the environment. An applied magnetic field was found to consistently reduce the system entropy. The external magnetic field increases entanglement for small strength, and if too strong, it reduces the entanglement. The maximum entanglement is formed from a balance of external magnetic field and the decay rate. The transitory level of entanglement in the system is found to oscillate with a frequency that is proportional to the magnetic field strength before reaching steady-state entanglement. It was found that collective decay produces more entanglement than individual decay.

This paper studies the ability of feedback control to reduce the effect of decoherence and enhance entanglement in an interacting spin-1/2 XY dimer model in the presence of a transverse magnetic field. The system reaches an improved steady state entanglement when feedback is present. The influence of the strength of the external B field is found for optimized steady state entanglement. The time-dependent entanglement evolution of the system is also studied. One potential application of this scheme is to raise the maximum operating temperature of spin entangled systems.

Abstract The goal of this study is the discovery of biomarkers reflecting the pharmacodynamic action of sulforaphane (SFN), initially in the normal human mammary epithelial MCF10A cell line and then in tissue obtained from healthy patients undergoing reduction mammoplasty surgery. SFN is formed by the hydrolysis of glucoraphanin, a water soluble glucosinolate found in cruciferous vegetables with especially high levels measured in 3 day old broccoli sprouts. Chemoprevention by SFN is achieved in part through the upregulation of cytoprotective enzymes via the Keap1/Nrf2 pathway. Preliminary dose response and time course studies in MCF10A cells established that SFN upregulated cytoprotective genes as indicated by increased levels of NQO1 transcripts, protein and activity. NQO1 induction is dependent on the Keap1/Nrf2 pathway since NQO1 transcripts, protein and activity were enhanced by KEAP1 siRNA knockdown in MCF10As. For the biomarker discovery phase isobaric tag for relative and absolute quantitation (iTRAQ) was used to quantify global protein changes using mass spectrometry. Two independent 8-plex iTRAQ experiments determined the pharmacological actions of SFN on protein expression, compared to a vehicle control, and the genetic regulation of protein expression following knockdown of KEAP1 compared to a non targeting control siRNA. In both experiments protein expression was analyzed at 12, 24, 48, and 72 hour time points after SFN treatment or KEAP1 knockdown. In addition to confirming NQO1 to be a good candidate biomarker, the iTRAQ analysis identified other upregulated candidates to be aldo-keto reductase family 1 member C1 (AKR1C1), DJ-1 protein, and thioredoxin. NQO1 and AKR1C1 transcripts were also elevated in the MCF10A cells, as assessed by microarray assay. Candidate biomarkers identified from microarray and iTRAQ studies reflecting the pharmacodynamic action of SFN in human cells will be analyzed by Western blot, qRT-PCR and enzyme assays in tissue from reduction mammoplasty patients. These women have been randomized in a clinical trial to receive either a broccoli sprout preparation containing 100 micomole SFN or a placebo beverage daily for 10 days prior to surgery. Supported by P50 CA088843, U54 RR020839 and BC073262. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5700.

An articulated-truss space-crane concept is described, and four articulating-joint (AJ) concepts are evaluated. The space-crane concept uses the same truss structure hardware as Space Station Freedom. The joint concepts are compared according to their actuator stroke ratio, actuator authority, and part count. One AJ concept is selected as a candidate space-crane joint because of its better performance and lower part count. The space-crane reach envelope is determined as a function of the number of AJs and the number of fixed-length booms. A space crane with three booms, three AJs, and one rotary joint provides an adequate reach envelope for an expected work area. The space-crane tip velocity, because of an allowable truss strut compressive load, is limited to approximately 1.0 in./sec for a 300,000-lbm payload. The displacement response is also shown for an emergency stop scenario as a function of the payload mass. The space-crane tip deflection is on the order of 12 in. for a 300,000-lbm payload.

The structural performance of two truss configurations, the orthogonal tetrahedral and a Warren-type, are compared using finite element models representing the November Reference Phase 1 Space Station. The truss torsional stiffness properties and fundamental torsion frequency are determined using cantilever truss-beam models. Frequencies, mode shapes, transient response, and truss strut compressive loads are compared for the two space station models. The performance benefit resulting from using a high modulus truss strut is also presented. Finally, assembly and logistics characteristics of the two truss configurations are evaluated.

This paper describes the structural dynamic characteristics of a NASA reference space station configuration as defined in the November 1987 Space Station Program - Systems Engineering and Integration Engineering Data Book. The modes and frequencies of the station below 2.0 Hz were obtained and selected results along with rigid body properties are presented. A three-axis attitude control system using control moment gyros responding to attitude and attitude rate signals is used to regulate the orientation of the station. The stability of the control system with non-collocated sensors is investigated for both compensated and uncompensated control signals. Results from a closed-loop simulation of a commanded attitude change about three axes, and from a closed-loop simulation of the response of the station to an externally applied unit force impulse at the docking port are presented. These simulation results are used to evaluate the possible degree of control/structures interaction which could occur during normal operation of the station.

Four methods for the calculation of derivatives of vibration mode shapes (eigenvectors) with respect to design parameters are described. These are finite-difference method, modal method, a modified modal method and Nelson's method. The methods are implemented in a general-purpose commercial finite-element program and applied to the following test problems: a cantilever beam and a stiffened cylinder with a cutout. Design variables are a beam tip mass, a beam root height, and specific dimensions of the cylinder model. The methods are compared on the basis of central processor (CP) seconds required to obtain the derivatives, and two of the methods are also evaluated for the rapidity of convergence. Data is presented showing the amount of CP time used to compute the first four eigenvector derivatives for each example problem. A scalar measure of the error in the mode shape derivative is defined, and numerical results illustrating the rapidity of convergence of the approximate derivative to the exact derivative are presented. Results indicate an advantage in using Nelson's method because this method is exact and requires less CP time, especially when derivatives with respect to several design variables are computed.

The structural dynamic characteristics of the International Space Station (ISS), the interim reference configuration established for NASA's Space Station developmental program, are discussed, and a finite element model is described. Modes and frequencies of the station below 2.0 Hz are derived, and the dynamic response of the station is simulated for an external impulse load corresponding to a failed shuttle-docking maneuver. A three-axis attitude control system regulates the ISS orientation, with control moment gyros responding to attitude and attitude rate signals. No instabilities were found in the attitude control system.

Results from an investigation of the dynamic behavior of a 300 kW class solar dynamic powered, dual kell space station are presented. The purpose of the investigation was to determine and assess the influence of space station truss bay size on station controllability during rigid body attitude adjustment and orbit reboost maneuvers. The dual keel space station concept is defined and two finite element models (one which has a truss bay size of 5m and another with a truss bay size of 9 feet) are described. Rigid and flexible body characteristics of the two space station models are also presented. Finally, results from a transient response analysis, where the stations are subjected to an orbit reboost maneuver, are summarized.

An initial description of an evolving relational database schema is presented for the management of finite element model design and analysis data. The report presents a description of each relation including attribute names, data types, and definitions. The format of this report is such that future modifications and enhancements may be easily incorporated.

A relational data base management system has been used for managing engineering data in a prototype computerized thermal/structural integrated design system. The resulting system has been applied to the analysis of a tetrahedral space truss to demonstrate and evaluate the ability to store, retrieve, query, modify, and manipulate data. Key software used includes relational data management software, several applications programs, and selected integrated software developed during the study. Results discussed include system development, system use and performance, and advantages of an integrated data management system.