Tim Marquart | AMiner学者主页

1Processes and intermediates for the preparation of purine derivatives useful in the treatment of (inter alia) cancer, asthma and diarrhea

Elfatih Elzein,Rao Kalla,Tim Marquart,J Zablocki,L I Xiaofen

2012引用：23

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2THE DISCOVERY OF AN A(1) ADENOSINE RECEPTOR PARTIAL AGONIST FOR THE TREATMENT OF TYPE II DIABETES

Jeff Zablocki,Elfatih Elzein,Rao Kalla,Xiaofen Li,Thao Perry,Tim Marquart,Malcolm McGregor,John Shryock,Lin Wu,Yuzhi Wu,Dewan Zeng,Nancy Chu,

2009DRUGS OF THE FUTURE（2009）

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3N-6-Cycloalkyl-2-Substituted Adenosine Derivatives As Selective, High Affinity Adenosine A(1) Receptor Agonists

Elfatih Elzein,Rao Kalla,Xiaofen Li,Thao Perry,Tim Marquart,Mark Micklatcher,Yuan Li,Yuzhi Wu,Dewan Zeng,Jeff Zablocki

A series of new selective, high affinity A1-AdoR agonists is reported. Compound 23 that incorporated a carboxylic acid functionality in the 4-position of the pyrazole ring displayed KiL value of 1 nM for the A1-AdoR and >5000-fold selectivity over the A3 and A2A-AdoRs. In addition, compound 19 that incorporated a carboxamide functionality in the 4-position of the pyrazole ring displayed subnanomolar affinity for the A1-AdoR (KiL = 0.6 nM) and >600-fold selectivity over the A3 and A2A-AdoRs.

2007BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2007）引用：34

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4A1 Adenosine Receptor Agonists As Ventricular Rate Control Agents During Atrial Fibrillation