The patient was a 44-year-old man who developed cognitive impairment beginning at the age of 35 years that gradually worsened. The cognitive impairment led to a difficult social life, and he retired from his company. After hospitalization and workup, he was diagnosed with primary progressive multiple sclerosis (PPMS) that presented only with cognitive impairment for 10 years. Since he had multiple predictive factors for poor prognosis, anti-CD20 monoclonal antibody therapy was implemented. Cognitive impairment and cerebral blood flow SPECT findings improved, and he returned to a social life 3 months later. Anti-CD20 monoclonal antibody therapy was effective in improving cognitive impairment in a case of an advanced stage of PPMS.

A 31-year-old man developed headache and generalized convulsions. At the time of the first seizure, there was no distinct MRI abnormality. He was admitted to the hospital with repeated seizures, left-sided hemiparesis, and left-sided neglect. He had a slight fever, elevated cerebrospinal fluid (CSF) pressure, and increased CSF cell count with predominance of mononuclear cells. A repeat MRI scan on day 8 after the recurrent seizure showed cortical edema in the right cerebral hemisphere on fluid-attenuated inversion recovery (FLAIR), abnormal high signal on DWI, and decreased apparent diffusion coefficient. The patient was diagnosed with aseptic meningoencephalitis and treated with antiviral drugs and methylprednisolone pulse therapy. Serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody was subsequently detected, and prednisolone was added to treat the FLAIR-hyperintense lesions in anti-MOG antibody associated encephalitis with seizures (FLAMES). It is important to identify the clinical picture and typical images of FLAMES to allow early treatment.

Glisson's capsule is the connective tissue present in the portal triad as well as beneath the liver surface. Little is known about how Glisson's capsule changes its structure in capsular fibrosis (CF), which is characterized by fibrogenesis beneath the liver surface. In this study, we found that the human liver surface exhibits multilayered capsular fibroblasts and that the bile duct is present beneath the mesothelium, whereas capsular fibroblasts are scarce and no bile ducts are present beneath the mouse liver surface. Patients with cirrhosis caused by alcohol abuse or hepatitis C virus infection show development of massive CF. To examine the effect of alcohol on CF in mice, we first injected chlorhexidine gluconate (CG) intraperitoneally and then fed alcohol for 1 month. The CG injection induces CF consisting of myofibroblasts beneath the mesothelium. One month after CG injection, the fibrotic area returns to the normal structure. In contrast, additional alcohol feeding sustains the presence of myofibroblasts in CF. Cell lineage tracing revealed that mesothelial cells give rise to myofibroblasts in CF, but these myofibroblasts disappear 1 month after recovery with or without alcohol feeding. Capsular fibroblasts isolated from the mouse liver spontaneously differentiated into myofibroblasts and their differentiation was induced by transforming growth factor beta 1 (TGF‐β1) or acetaldehyde in culture. In alcohol‐fed mice, infiltrating CD11b+Ly‐6CLow/– monocytes had reduced mRNA expression of matrix metalloproteinase 13 and matrix metalloproteinase 9 and increased expression of tissue inhibitor of matrix metalloproteinase 1, Tgfb1, and interleukin‐10 during resolution of CF. Conclusion: The present study revealed that the structure of Glisson's capsule is different between human and mouse livers and that alcohol impairs the resolution of CF by changing the phenotype of Ly‐6CLow/– monocytes.

Background: Hepatic stellate cells (HSCs) play an important role in liver fibrogenesis. However, little is known about their phenotype and role in liver development. The aim of this study is to identify specific markers for embryonic HSCs. Results: Using antibodies against ALCAM and PDPN, we separated mesothelial cells (MCs) and HSCs from developing livers and identified integrin α8 (ITGA8) as a marker for embryonic desmin+ HSCs that are preferentially localized near the developing liver surface and α‐smooth muscle actin+ perivascular mesenchymal cells around the vein. A cell lineage–tracing study revealed that upon differentiation, MC‐derived HSCs or perivascular mesenchymal cells express ITGA8 during liver development. Using anti‐ITGA8 antibodies, we succeeded in isolating MC‐derived HSCs and perivascular mesenchymal cells from embryonic livers. In direct co‐culture, ITGA8+ mesenchymal cells promoted the expression of hepatocyte and cholangiocyte markers in hepatoblasts. In the normal adult liver, expression of ITGA8 was restricted to portal fibroblasts in the portal triad. Upon liver injury, myofibroblasts increased the expression of ITGA8. Conclusions: ITGA8 is a specific cell surface marker of MC‐derived HSCs and perivascular mesenchymal cells in the developing liver. Our data suggest that ITGA8+ mesenchymal cells maintain the phenotype of hepatoblast in liver development. Developmental Dynamics 247:867–881, 2018. © 2018 Wiley Periodicals, Inc.

We consider asymptotic convertibility of an arbitrary sequence of bipartite pure states into another by local operations and classical communication (LOCC). We adopt an information-spectrum approach to address cases where each element of the sequences is not necessarily a tensor power of a bipartite pure state. We derive necessary and sufficient conditions for the LOCC convertibility of one sequence to another in terms of spectral entropy rates of entanglement of the sequences. Based on these results, we also provide simple proofs for previously known results on the optimal rates of entanglement concentration and dilution of general sequences of bipartite pure states.

There are different inequivalent ways to define the Rényi capacity of a channel for a fixed input distribution. In [IEEE Transactions on Information Theory, 41(1):26-34, 1995], Csiszár has shown that for classical discrete memoryless channels there is a distinguished such quantity that has an operational interpretation as a generalized cutoff rate for constant composition channel coding. We show that the analogous notion of Rényi capacity, defined in terms of the sandwiched quantum Rényi divergences, has the same operational interpretation in the strong converse problem of constant composition classical-quantum channel coding.

To reconstruct thermodynamics based on the microscopic laws is one of the most important unfulfilled goals of statistical physics. Here, we show that the first law and the second law for adiabatic processes are derived from an assumption that "probability distributions of energy in Gibbs states satisfy large deviation", which is widely accepted as a property of thermodynamic equilibrium states. We define an adiabatic transformation as a randomized energy-preserving unitary transformations on the many-body systems and the work storage. As the second law, we show that an adiabatic transformation from a set of Gibbs states to another set of Gibbs states is possible if and only if the regularized von Neumann entropy becomes large. As the first law, we show that the energy loss of the thermodynamic systems during the adiabatic transformation is stored in the work storage as "work," in the following meaning; (i) the energy of the work storage takes certain values macroscopically, in the initial state and the final state. (ii) the entropy of the work storage in the final state is macroscopically equal to the entropy of the initial state. As corollaries, our results give the principle of maximam work and the first law for the isothermal processes.

We consider asymptotic convertibility of an arbitrary sequence of bipartite pure states into another by local operations and classical communication (LOCC). We adopt an information-spectrum approach to address cases where each element of the sequences is not necessarily in tensor power of a bipartite pure state. We derive necessary and sufficient conditions for the LOCC convertibility of one sequence to another in terms of spectral entropy rates of entanglement of the sequences. Based on these results, we also provide simple proofs for previously known results on the optimal rates of entanglement concentration and dilution of general sequences of pure states.

This book presents the basics of quantum information, e.g., foundation of quantum theory, quantum algorithms, quantum entanglement, quantum entropies, quantum coding, quantum error correction and quantum cryptography. The required knowledge is only elementary calculus and linear algebra. This way the book can be understood by undergraduate students. In order to study quantum information, one usually has to study the foundation of quantum theory. This book describes it from more an operational viewpoint which is suitable for quantum information while traditional textbooks of quantum theory lack this viewpoint. The currentbook bases on Shor's algorithm, Grover's algorithm, Deutsch-Jozsa's algorithm as basic algorithms. To treat several topics in quantum information, this book covers several kinds of information quantities in quantum systems including von Neumann entropy. The limits of several kinds of quantum information processing are given. As important quantum protocols, this book contains quantum teleportation, quantum dense coding, quantum data compression. In particular conversion theory of entanglement via local operation and classical communication are treated too. This theory provides the quantification of entanglement, which coincides with von Neumann entropy. The next part treats the quantum hypothesis testing. The decision problem of two candidates of the unknown state are given. The asymptotic performance of this problem is characterized by information quantities. Using this result, the optimal performance of classical information transmission via noisy quantum channel is derived. Quantum information transmission via noisy quantum channel by quantum error correction are discussed too. Based on this topic, the secure quantum communication is explained. In particular, the quantification of quantum security which has not been treated in existing book is explained. This book treats quantum cryptography from a more practical viewpoint.

We present two general approaches to obtain the strong converse exponent of simple quantum hypothesis testing for correlated quantum states. One approach requires that the states satisfy a certain factorization property; typical examples of such states are the temperature states of translation-invariant finite-range interactions on a spin chain. The other approach requires the differentiability of a regularized Renyi alpha-divergence in the parameter a; typical examples of such states include temperature states of non-interacting fermionic lattice systems, and classical irreducible Markov chains. In all cases, we get that the strong converse exponent is equal to the Hoeffding anti-divergence, which in turn is obtained from the regularized Renyi divergences of the two states.

We show that the new quantum extension of Rényi’s α-relative entropies, introduced recently by Müller-Lennert et al. (J Math Phys 54:122203, 2013) and Wilde et al. (Commun Math Phys 331(2):593–622, 2014), have an operational interpretation in the strong converse problem of quantum hypothesis testing. Together with related results for the direct part of quantum hypothesis testing, known as the quantum Hoeffding bound, our result suggests that the operationally relevant definition of the quantum Rényi relative entropies depends on the parameter α: for α < 1, the right choice seems to be the traditional definition \({{D_\alpha^{(old)}} (\rho \| \sigma) :=\frac{1}{\alpha-1} \,\,{\rm log\,\,Tr}\,\, \rho^{\alpha} \sigma^{1-\alpha}}\), whereas for α > 1 the right choice is the newly introduced version \({D_\alpha^{(new)}} (\rho \| \sigma) := \frac{1}{\alpha-1}\,{\rm log\,\,Tr}\,\big(\sigma^{\frac{1-\alpha}{2 \alpha}}\rho \sigma^{\frac{1-\alpha}{2 \alpha}}\big)^{\alpha}\).On the way to proving our main result, we show that the new Rényi α-relative entropies are asymptotically attainable by measurements for α > 1. From this, we obtain a new simple proof for their monotonicity under completely positive trace-preserving maps.

In this chapter, an elementary quantum mechanics (QM) is introduced through qubit systems (quantum systems with two levels). The reader can get familiar with physical concepts and mathematical tools of QM and will be ready to proceed to the applications of quantum information science.

Quantum information science is a future information science. This chapter explains the significance of quantum information science, and the distinction between conventional information science and quantum information science. Then, it describes a future vision of the realization of quantum information processing. This chapter ends with the description of the organization of this book.

Quantum entanglement is a striking feature of quantum mechanics, and clarifying its properties is crucially important for the development of quantum information technology. In recent years, the theory of entanglement has been rapidly developed along with quantum information theory. In particular, introducing the concept of local operations and classical communication enables us to quantify the amount of entanglement, and leads to our much better understanding of quantum entanglement. In this chapter, the various properties of quantum entanglement are explained.

In quantum information theory, it is indispensable to develop and utilize information quantities in quantum systems, for quantifying the efficiency of quantum information processing. At the first part of this chapter, corresponding classical information quantities are described, along with the notion of typical sequences for understanding of the meaning of the entropy. Using these knowledge, we treat the theory of quantum information quantities, such as the von Neumann entropy, the quantum relative entropy, the quantum mutual information, and the fidelity.

In this chapter, we introduce the general theory of QM with two formulations. The first one is based on the Postulates (Axioms) of QM, which rather follows a traditional view, while the second one is devised for an application of quantum information science in a way to clarify the most general classes of quantum states, measurements, and time evolutions of a given quantum system under the possible presence of environment. By specifying the underling preconditions, we carefully explain their logical and physical connections between superficially different formulations.

We show representative quantum algorithms, Deutsch-Jozsa algorithm, Grover’s algorithm and Shor’s algorithm, in this chapter. We also analyze how these quantum algorithms work.

A 75-year-old man developed hearing loss and hoarseness; 5 months later, he suffered from headache and loss of appetite. A blood test showed an inflammatory reaction, a high level of serum IgG4 (254.0 mg/dl), and positive reaction for MPO-ANCA. Gadolinium enhanced T1 weighted head magnetic resonance imaging (MRI) revealed dural thickening with marked enhancement. Infiltration of lymphocytes and anti-IgG4-positive plasma cells were detected in the dura mater by meningeal biopsy; thus, he was diagnosed with MPO-ANCA-positive IgG4-related hypertrophic pachymeningitis. His clinical manifestations, and serologic and MRI findings improved with steroid treatment; however, they recurred during steroid tapering and he presented with right orbital apex syndrome. We then added an immunosuppressive drug to his regimen. It was difficult to reduce the symptoms of this case, with oral steroid monotherapy, and its combination with an immunosuppressive drug was necessary.

We present two general approaches to obtain the strong converse rate of quantum hypothesis testing for correlated quantum states. One approach requires that the states satisfy a certain factorization property; typical examples of such states are the temperature states of translation-invariant finite-range interactions on a spin chain. The other approach requires the differentiability of a regularized R\'enyi $\alpha$-divergence in the parameter $\alpha$; typical examples of such states include temperature states of non-interacting fermionic lattice systems, and classical irreducible Markov chains. In all cases, we get that the strong converse exponent is equal to the Hoeffding anti-divergence, which in turn is obtained from the regularized R\'enyi divergences of the two states.