To date, 10 types of human papillomavirus have been identified that cause flat warts, including human papillomavirus type 3, which belongs to species group 2 of the genus alpha papillomavirus. Among these 10 types, human papillomavirus type 94 is most closely related to human papillomavirus type 10, sharing 86% homology. In this study, we conducted polymerase chain reaction analysis with sequencing on samples obtained from cutaneous lesions located on the face and lower legs of an individual, revealing the presence of human papillomavirus type 94. Dermatoscopic findings revealed numerous dotted vessels within one group of macular brown lesions located on the lower leg, which contributed to the diagnosis of flat warts. An online search revealed that human papillomavirus type 94 has previously been detected in various skin diseases, and we provide a review of prior reports.

The Journal of DermatologyEarly View LETTER TO THE EDITOR Unusual clinical presentation of extragenital condyloma acuminatum Daisuke Yano, Daisuke Yano Department of Dermatology, Japanese Red Cross Saitama Hospital, Chuo-ku, Saitama, Japan Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, JapanSearch for more papers by this authorIkuroh Ohsawa, Ikuroh Ohsawa orcid.org/0000-0002-7212-9298 Department of Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanSearch for more papers by this authorYasushi Suga, Yasushi Suga orcid.org/0000-0003-3643-2879 Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, JapanSearch for more papers by this authorTsuyoshi Mitsuishi, Corresponding Author Tsuyoshi Mitsuishi [email protected] orcid.org/0000-0003-2277-0201 Department of Dermatology, Japanese Red Cross Saitama Hospital, Chuo-ku, Saitama, Japan Correspondence Tsuyoshi Mitsuishi, Department of Dermatology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-ku, Saitama, Japan. Email: [email protected]Search for more papers by this author Daisuke Yano, Daisuke Yano Department of Dermatology, Japanese Red Cross Saitama Hospital, Chuo-ku, Saitama, Japan Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, JapanSearch for more papers by this authorIkuroh Ohsawa, Ikuroh Ohsawa orcid.org/0000-0002-7212-9298 Department of Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, JapanSearch for more papers by this authorYasushi Suga, Yasushi Suga orcid.org/0000-0003-3643-2879 Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, JapanSearch for more papers by this authorTsuyoshi Mitsuishi, Corresponding Author Tsuyoshi Mitsuishi [email protected] orcid.org/0000-0003-2277-0201 Department of Dermatology, Japanese Red Cross Saitama Hospital, Chuo-ku, Saitama, Japan Correspondence Tsuyoshi Mitsuishi, Department of Dermatology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-ku, Saitama, Japan. Email: [email protected]Search for more papers by this author First published: 03 March 2024 https://doi.org/10.1111/1346-8138.17184Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Zhu D, Fang H, Qiao J, Liu X, Xu B, Si Z. Giant warts in a Chinese with epidermodysplasia verruciformis. Indian J Dermatol Venereol Leprol. 2011; 77: 730. 10.4103/0378-6323.86506 PubMedWeb of Science®Google Scholar 2Kuraishi N, Shimizu A, Kato M, Takeuchi Y, Tamura A. Giant condyloma acuminatum in the axilla. Acta Derm Venereol. 2015; 95: 355–356. 10.2340/00015555-1935 PubMedWeb of Science®Google Scholar 3Mitsuishi T, Sata T, Matsukura T, Iwasaki T, Kawashima M. The presence of mucosal human papillomavirus in Bowen's disease of the hands. Cancer. 1997; 79: 1911–1917. 10.1002/(SICI)1097-0142(19970515)79:10<1911::AID-CNCR11>3.0.CO;2-Y CASPubMedWeb of Science®Google Scholar 4Mitsuishi T, Kawana S, Kato T, Kawashima M. Human papillomavirus infection in actinic keratosis and Bowen's disease: comparative study with expression of cell-cycle regulatory proteins p21(Waf1/Cip1), p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions. Hum Pathol. 2003; 34: 886–892. 10.1016/S0046-8177(03)00352-6 CASPubMedWeb of Science®Google Scholar 5Shimizu A, Tamura A, Abe M, Amano H, Motegi S, Nakatani Y, et al. Human papillomavirus type 56-associated Bowen disease. Br J Dermatol. 2012; 167: 1161–1164. 10.1111/j.1365-2133.2012.11071.x CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation

東京女子医大八千代医療センター及びさいたま赤十字病院で診療した乳児血管腫(infantile hemangioma: IH)207例中,頭部・顔面IHの79例に対して波長595 nmのパルス幅可変式色素レーザー照射あるいは薬物治療としてプロプラノロール内服治療,その併用である'ハイブリッド療法'を生命予後を脅かす部位や機能障害を残す部位のハイリスクIH症例らに対して治療を行なった.また頭部・顔面以外の重篤な後遺症を残さないIHで経過観察を行なった症例と何らかの治療を行なった頭部・顔面IH症例の12週間後,24週間後の改善を5項目のrating scaleで評価し,統計学的に比較検討した結果,治療群では24週間後には経過観察群と比較してIHの改善に有意な差が認められた.従って重篤な後遺症を残さないためにも頭部・顔面IHに対しては積極的にレーザー治療,薬物治療を取り組むべきであると考えられた.

The Journal of DermatologyVolume 49, Issue 8 p. e293-e294 LETTER TO THE EDITOR Author reply to “Onycholysis associated with Kawasaki disease: A comment on characteristic nail lesions in Kawasaki disease: Case series and literature review” Tsuyoshi Mitsuishi, Corresponding Author Tsuyoshi Mitsuishi [email protected] orcid.org/0000-0003-2277-0201 Department of Dermatology, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, Japan Department of Dermatology, Japanese Red Cross Saitama Hospital, Saitama, Japan Correspondence Tsuyoshi Mitsuishi, Department of Dermatology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-ku, Saitama 330-8553, Japan. Email: [email protected]Search for more papers by this authorKazunori Miyata, Kazunori Miyata orcid.org/0000-0002-7931-6045 Department of Dermatology, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorAkiko Ando, Akiko Ando orcid.org/0000-0003-2842-8909 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorKentaro Sano, Kentaro Sano orcid.org/0000-0002-2436-2036 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorJun-ichi Takanashi, Jun-ichi Takanashi orcid.org/0000-0002-1147-1938 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorHiromichi Hamada, Hiromichi Hamada orcid.org/0000-0002-8990-5265 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, Japan Department of Pediatrics, Chiba University, Chiba, JapanSearch for more papers by this author Tsuyoshi Mitsuishi, Corresponding Author Tsuyoshi Mitsuishi [email protected] orcid.org/0000-0003-2277-0201 Department of Dermatology, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, Japan Department of Dermatology, Japanese Red Cross Saitama Hospital, Saitama, Japan Correspondence Tsuyoshi Mitsuishi, Department of Dermatology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-ku, Saitama 330-8553, Japan. Email: [email protected]Search for more papers by this authorKazunori Miyata, Kazunori Miyata orcid.org/0000-0002-7931-6045 Department of Dermatology, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorAkiko Ando, Akiko Ando orcid.org/0000-0003-2842-8909 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorKentaro Sano, Kentaro Sano orcid.org/0000-0002-2436-2036 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorJun-ichi Takanashi, Jun-ichi Takanashi orcid.org/0000-0002-1147-1938 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, JapanSearch for more papers by this authorHiromichi Hamada, Hiromichi Hamada orcid.org/0000-0002-8990-5265 Department of Pediatrics, Tokyo Women’s Medical University Yachiyo Medical Center, Chiba, Japan Department of Pediatrics, Chiba University, Chiba, JapanSearch for more papers by this author First published: 23 April 2022 https://doi.org/10.1111/1346-8138.16408Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Mitsuishi T, Miyata K, Ando A, Sano K, Takanashi JI, Hamada H. Characteristic nail lesions in Kawasaki disease: case series and literature review. J Dermatol. 2022; 49: 232–8. 2Otani A, Iio K, Hataya H. Onycholysis associated with Kawasaki disease: a comment on Mitsuishi et al. J Dermatol. 2022. Online ahead of print. 3Iosub S, Gromisch DS. Leukonychia partialis in Kawasaki disease. J Infect Dis. 1984; 150: 617–8. 4Berard R, Scuccimarri R, Chédeville G. Leukonychia striata in Kawasaki disease. J Pediatr. 2008; 152: 889. 5Banday AZ, Neelam H, Jindal AK. Spatio-temporal evolution of onychomadesis in a child with missed Kawasaki disease. Clin Rheumatol. 2020; 39: 2237–8. 6Singh A, Pilania RK, Thapa B, Vignesh P, Singh S. Onycholysis-an uncommon finding in Kawasaki disease. J Clin Rheumatol. 2020; 26: e128–9. Volume49, Issue8August 2022Pages e293-e294 ReferencesRelatedInformation

Dear Editor, Infantile hemangioma (IH) occurs in a small percentage of infants and is the most frequently occurring benign tumor in infancy.1,2 In most cases, rapid growth occurs during the first 1– 3 months of life, and the proliferative phase lasts until approximately 1 year of age. In contrast, capillary malformation (CM) describes reddish macules that are typically present at birth. Although CM is not strictly classified as a hemangioma, it is considered a malformation. In adults, CM on the face can become prominent and disfiguring. Both IH and CM are almost exclusively treated with dye laser therapy. The recent approval of oral propranolol has resulted in increasing use, either alone or in combination with laser therapy, especially for the treatment of

Kawasaki disease (KD) is vasculitis of unknown etiology in infants and young children. The diagnostic criteria for KD include major and minor symptoms, but various nail lesions are not described in detail. The aim of this study was to identify symptoms that are relatively found in nail of KD as diagnostic markers. After literature review, various nail lesions are classified as Beau's lines, leukonychia, onychomadesis, orange-brown chromonychia, and pincer nail deformity. The orange-brown chromonychia is the most common nail lesion in KD. In this study, the authors found three cases of KD with orange-brown chromonychia; two of these cases included rare dotted or splinter hemorrhages in the nail bed that were found on dermoscopic examination. The authors propose that these nail lesions, including hemorrhage of the nail bed, could be included as a helpful diagnosis of KD.

Trial design: Human papillomavirus infection causes verruca vulgaris. CDK9 inhibitor FIT039 inhibits DNA virus proliferation in animal models. We conducted a multicenter, single-blind, placebo-controlled, randomized phase I/II clinical trial evaluating the safety and efficacy of FIT039 against verruca vulgaris. Methods: Target lesions were treated with liquid nitrogen once, and a FIT039 patch or placebo patch was applied for 14 days. The primary endpoint was lesion disappearance. The secondary endpoints were safety and changes in dimension, cross-sectional area, and the number of petechial lesions. Results: A total of 24 participants were randomly allocated to the FIT039 (n = 13, median age, 54 years) and placebo (n = 11, median age, 62 years) groups. Verruca vulgaris did not disappear. FIT039 decreased the dimension to 76% of the initial value on day 29, followed by an increase to 98% on day 57. Placebo showed a monotonic increase to 107% on day 57. Changes in the cross-sectional area and petechiae number were comparable between the groups. Conclusions: No drug-related adverse reactions occurred. FIT039 efficacy was not determined in this study.

We present a case of so-called butcher’s warts in a meat handler with atopic dermatitis. PCR with direct sequence analysis confirmed the presence of HPV 7 in the hand warts of the patient. Histopathologically, the lesion contained vacuolated cells with centered nuclei, and there were no abundant keratohyalin granules in the granular layer. Clinically, HPV 7-induced warts tend to appear on the hands of meat/fish handlers or cutters in the world. Therefore, meat/fish had been thought to act as a vector for the transmission of HPV 7. In our case, the Japanese patient’s occupation required the handling of meat/fish products, and HPV 7 was found from his hand warts. This evidence indicated that HPV 7 was widely distributed in the world. However, this patient worked in a Japanese restaurant, which required the handling of meat/fish products with tools such as knives and chopping boards. Therefore, we suggested that HPV 7 might be correlated with specific reservoirs.

The Journal of DermatologyVolume 47, Issue 5 p. e203-e204 Letter to the Editor Combined therapies of oral retinoid and topical salicylic acid in recalcitrant pigmented warts of a child Rena Tsukahara, Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorKazunori Miyata, Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorUsho Go, orcid.org/0000-0002-7357-3980 Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorTsuyoshi Mitsuishi, Corresponding Author mitsuishi.tsuyoshi@twmu.ac.jp orcid.org/0000-0001-6696-5524 Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, Japan Correspondence: Tsuyoshi Mitsuishi, M.D., Ph.D., Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, 477-96 Ohwada-Shinden, Yachiyo, Chiba 276-8524, Japan. Email: mitsuishi.tsuyoshi@twmu.ac.jpSearch for more papers by this author Rena Tsukahara, Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorKazunori Miyata, Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorUsho Go, orcid.org/0000-0002-7357-3980 Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, JapanSearch for more papers by this authorTsuyoshi Mitsuishi, Corresponding Author mitsuishi.tsuyoshi@twmu.ac.jp orcid.org/0000-0001-6696-5524 Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, Yachiyo, Japan Correspondence: Tsuyoshi Mitsuishi, M.D., Ph.D., Department of Dermatology, Tokyo Women’s Medical University, Yachiyo Medical Center, 477-96 Ohwada-Shinden, Yachiyo, Chiba 276-8524, Japan. Email: mitsuishi.tsuyoshi@twmu.ac.jpSearch for more papers by this author First published: 05 March 2020 https://doi.org/10.1111/1346-8138.15302Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume47, Issue5May 2020Pages e203-e204 RelatedInformation

To the best of our knowledge, 11 reports have described the efficacy of the bivalent human papillomavirus vaccine (BHPV) and quadrivalent human papillomavirus vaccine (QHPV) in the treatment of cutaneous warts1-3 . Nine reports described the complete regression of cutaneous warts in all patients treated with BHPV or QHPV (total of 16 cases). On the other hand, Abeck and Fölster-Holst2 reported that 10 of 16 patients were cured, with younger patients having better cure rates.

Vol. 31, No. 3, 2019 339 Received January 19, 2018, Revised April 11, 2018, Accepted for publication April 25, 2018 Corresponding author: Tsuyoshi Mitsuishi, Department of Dermatology, Tokyo Women’s Medical University Yachiyo Medical Center, 477-96, Ohwada-Shinden, Yachiyo, Chiba 276-8524, Japan. Tel: 81-47-450-6000, Fax: 81-47-458-7047, E-mail: tmitsu@twmu.ac.jp ORCID: https://orcid.org/0000-0001-6696-5524 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology pISSN 1013-9087ᆞeISSN 2005-3894 Ann Dermatol Vol. 31, No. 3, 2019 https://doi.org/10.5021/ad.2019.31.3.339