24th Biennial International Congress on Thrombosis / EMLTD Congress -- MAY 04-07, 2016 -- Istanbul, TURKEY

Because of the teratogenicity data in rats, it is recommended that women treated with imatinib should be aware of the potential teratogenicity of imatinib and effective contraception should be used during imatinib therapy to prevent pregnancy. We describe successful pregnancy and delivery, without any congenital anomaly, in a patient with CML under treatment of imatinib. The fetus had been exposed to imatinib for 8 weeks. The patient remained off treatment during gestation and cytogenetic relapse of CML (5 months after discontinuation of imatinib therapy) developed at seventh month of gestation.

CytopathologyVolume 16, Issue 5 p. 262-263 Small cell lung cancer presenting as acute leukaemia R. Ali, R. AliSearch for more papers by this authorF. Ozkalemkas, F. OzkalemkasSearch for more papers by this authorT. Ozcelik, T. OzcelikSearch for more papers by this authorU. Ozan, U. OzanSearch for more papers by this authorV. Ozkocaman, V. OzkocamanSearch for more papers by this authorA. Tunali, A. TunaliSearch for more papers by this authorS. Balaban-Adim, S. Balaban-AdimSearch for more papers by this author R. Ali, R. AliSearch for more papers by this authorF. Ozkalemkas, F. OzkalemkasSearch for more papers by this authorT. Ozcelik, T. OzcelikSearch for more papers by this authorU. Ozan, U. OzanSearch for more papers by this authorV. Ozkocaman, V. OzkocamanSearch for more papers by this authorA. Tunali, A. TunaliSearch for more papers by this authorS. Balaban-Adim, S. Balaban-AdimSearch for more papers by this author First published: 22 September 2005 https://doi.org/10.1111/j.1365-2303.2005.00233.xCitations: 7 Dr Ridvan Ali, Division of Hematology, Department of Internal Medicine, Uludag University School of Medicine, Bursa, Turkey. Tel.: +90 224 4428400; Fax: +90 224 4428060; E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Pisick E, Jagadeesh S, Salgia R. Small cell lung cancer: from molecular biology to novel therapeutics. J Exp Ther Oncol 2003; 3: 305–18. 2 Cote RJ, Hawes D, Chaiwun B, Beattie EJ. Detection of occult metastases in lung carcinomas: progress and implications for lung cancer staging. J Surg Oncol 1998; 69: 2652–74. 3 Jafri NF, Ma PC, Maulik G, Salgia R. Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer. J Environ Pathol Toxicol Oncol 2003; 22: 147–65. 4 Molad Y, Stark P, Prokocimer M, Joshua H, Pinkhas J, Sidi Y. Hemophagocytosis by small cell lung carcinoma. Am J Hematol 1991; 36: 154–6. 5 Sandberg AA, Stone JF, Czarnecki L, Cohen JD. Hematologic masquerade of rhabdomyosarcoma. Am J Hematol 2001; 68: 51–7. 6 Ali R, Özkalemkas F, Ozan Ü et al. Rhabdomyosarcoma of the perianal region presenting as acute leukemia. Ann Hematol 2004; 83: 729–30. Citing Literature Volume16, Issue5October 2005Pages 262-263 ReferencesRelatedInformation

(2004). Primary Non-Hodgkin's T-cell Lymphoma of Bone. Leukemia & Lymphoma: Vol. 45, No. 8, pp. 1719-1720.

We describe the successful management of a 30-year-old woman in the second trimester of her pregnancy with chronic lymphocytic leukemia (CLL) in stage IV by using only leukapheresis. We applied three sessions (courses) of leukapheresis throughout the pregnancy. The procedure did not have any significant adverse effect on the patient and the fetus. The patient gave birth vaginally to a healthy boy, weighing 3100 g, at 39 weeks of gestation. Seven months after delivery, Richter's syndrome developed in the patient. We conclude that leukapheresis may provide an alternative for palliative treatment to chemotherapy in pregnant patients with CLL. To our knowledge, this is the fourth reported case of CLL in pregnancy, and the first management of CLL during pregnancy with leukapheresis.

Although infrequently seen, the management of cancer during pregnancy can be difficult for patients, their families and physicians. The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 26-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in chronic phase by using only leukapheresis. She was treated with leukapheresis until her delivery at 36 weeks of gestation. The procedure was without significant adverse effects on the patient or fetus. We applied a total of 15 leukapheresis treatments throughout the pregnancy. The patient gave birth vaginally to a healthy 2800 g boy at 36 weeks of gestation. We conclude that leukapheresis may provide an alternative treatment to chemotherapy, alpha-interferon or imatinib in pregnant patients with CML, particularly with concern over their potential teratogenic and other adverse effects.

We observed 13 pregnant women of 70 females with idiopathic thrombocytopenic purpura (ITP) from January 1992 through September 2002. Thirteen mothers with ITP gave birth to twelve babies and two fetuses died. One of the pregnancies produced twins. Seven of the cases were diagnosed with ITP before pregnancy and six during pregnancy. One of the thirteen pregnancies was complicated by preeclampsia, one by ablatio placentae, and one by intrauterine death. Seven mothers received corticosteroid treatment, four high-dose immunoglobulin therapies, and one underwent splenectomy in the second trimester of gestation. At the time of delivery six mothers had normal platelet counts and seven had low platelet counts. Nine deliveries were by vaginal route and four were by cesarean section. Eleven infants were born with normal platelet counts and one was thrombocytopenic at the time of delivery. No infant showed any clinical signs of hemorrhage and there were no neonatal complications. Two fetuses died; one of them because of ablatio placentae and the other was intrauterine dead. In conclusion, ITP in pregnancy requires the management of two patients, the mother and her baby; hence, the close collaboration of a multidisciplinary group composed of a hematologist, obstetrician, anesthesiologist, and neonatologist is essential.

Primary pulmonary lymphoma arising from mucosa- or bronchus-associated lymphoid tissue (MALT or BALT) is a rare disease.1,2 We report a 30 year old man with low grade B cell BALT lymphoma who presented with a bulky mass in the lung and was treated successfully with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) combined chemotherapy. The patient was admitted with a dry cough, shortness of breath, back pain, and progressive infiltrates on chest radiographs. He had no …

Acquired hemophilia is a rare, life threatening coagulopathy in adults caused by the development of autoantibodies against to factor VIII. No general consensus exists on the best therapeutic approach. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and treated successfully with steroid therapy alone but complicated with a life threatening thromboembolic attack during her follow up. In conclusion, corticosteroids are "cost effective therapy" associated with high inhibitor elimination rates and although recurrence of inhibitor in a patient with factor VIII inhibitor is an expected clinical situation thrombosis risk should also be considered.

The incidence of acute leukemia in pregnancy is low and the management of acute leukemia during pregnancy is difficult. We have observed a total of 10 pregnancies in 8 patients. Six of the patients had acute myeloblastic leukemia (AML) and two of them had acute lymphoblastic leukemia (ALL). Three of the pregnancies were diagnosed when the leukemia was in remission, six at the time of leukemia diagnosis and one at the time of leukemic relapse. Six of the pregnancies were found in first trimester, three in the second and one early in the third. Three pregnancies ended with spontaneous abortion, three with intrauterine death and three with medical termination. One of spontaneous abortions and one intrauterine death developed during combination chemotherapy (daunorubicin, cytarabine). Only 1 healthy baby survived from the 10 pregnancies and this child was the not exposed to chemotherapeutic agents. None of the cases had gynecologic and obstetric complications. Five of eight pregnant women with leukemia died because of the primary disease.

PURPOSE:To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression. METHODS:No medication was given to 21 rats in group 1; 1.5 mg/m2/day topotecan was administered intraperitoneally for five days every three weeks to 21 rats in group II; a single dose of 5 microg/kg filgrastim was injected intraperitoneally 24 hours before the intraperitoneal administration of the same dose of topotecan to 21 rats in group III. After completion of six cycles of chemotherapy. the rats were decapitated and blood samples were immediately collected into citrated tubes for complete blood counts. RESULTS:White blood cell and lymphocyte counts in the control and the filgrastim + topotecan groups were similar (p > 0.05) and significantly higher than the counts in the topotecan group (p < 0.05). There was no difference in means of neutrophil, monocyte, eosinophil, basophil and erythrocyte counts among the groups (p > 0.05). CONCLUSION:Filgrastim administration prior to chemotherapy seems to be beneficial and further investigations are needed.

Pulmonary manifestations of systemic lupus erythematosus (SLE) include acute lupus pneumonitis, chronic interstitial pneumoni-tis, diaphragmatic dysfunction, atelectasis, pulmonary vascular disease, upper airway dysfunction, and bronchiolitis obliterans. 1 Pneumonia due to infection also develops because infection is a major cause of death of patients with SLE. 2 3 Here, we report a patient with SLE who suffered from an ambulatory lung consolidation devoid of pathogens. A 61 year old woman with SLE had been treated with 10 mg prednisolone every other day since 1990 without deterioration in the disease. She had complained of cough, non-purulent sputum, and fever once or twice a month since September 1998 which resolved spontaneously within a few days. In October 1999 she was first admitted to hospital with a lung consolidation and an ambient faint infiltrate over the left S4 and S6b on the chest radiograph and computed tomographic (CT) scan (fig 1A, D). She had pancytopenia, increased levels of C reactive protein and LDH, a high titre of anti-double strand DNA antibody, and decreased levels of complement titres. Analysis of bronchoalveolar lavage fluid and histopathological examination of trans-bronchial lung biopsy specimens showed an increased number of lymphocytes with a low CD4/CD8 ratio. The presence of neither microorganisms nor granulomas was confirmed. She was discharged because the consolidation was reduced (fig 1B, E). In March 2000 she had another bronchoscopic examination because of deterioration of the consolidation (fig 1C, F) but the results were the same as in 1999. For the purpose of further examination we conducted a partial lung resection. The affected lung tissue histopathologically showed a non-specific inflammatory nodule which consisted of lymphocyte dominant inflammatory cell infiltration, lymph follicle formation, fibrosis, fibrin exudation, a thickened alveolar septum, and collapsed alveoli without infectious microorganisms or malignant cells. Removal of the affected lung tissue resulted in improvement in symptoms and abnormal data. Non-specific inflammatory nodules might occur as a complication of SLE, and a surgical intervention should be considered to diagnose and treat the disease. Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1000 patients. Atypical mycobacterial infection, starvation and effect of BCG vaccination on tuberculin skin test Wang et al 1 are right when they underline the need to adjust for confounding variables when analysing the results of a tuberculin skin test (TST) survey, but they are oversim-plistic when, using surveys done in many countries worldwide, they …