Introduction: few studies have been carried out on therapeutic options in patients with painful bladder syndrome associated with interstitial cystitis. The aim is to verify the safety and effectiveness of treatment with sodium hyaluronate through intravesical instillation in patients with painful bladder syndrome.Materials and methods: a series of 18 female patients is presented, with a mean age of 51 years and prior diagnosis of painful bladder syndrome, who were treated by means of the weekly infusion of an intravesical solution of 40 mg of sodium hyaluronate in sterile solution, over a period of eight weeks. The patients were examined clinically and urodynamically prior to their inclusion in the study and eight months after the instillations had concluded.Results: there was a statistically significant improvement in the urodynamic parameters and in the symptoms measured quantitatively by means of the questionnaire "Pelvic Pain and Urgency/Frequency" between the baseline situation and after the vesical instillation of sodium hyaluronate in patients with painful bladder syndrome. There was no toxicity arising from the treatment, given that no adverse effects were recorded in relation to it.Conclusion: the clinical use of intravesical hyaluronic acid in patients with painful bladder syndrome possibly associated with interstitial cystitis has been demonstrated. The clinical improvement is also associated both with increased bladder capacity and improved bladder sensitivity. Tolerance was excellent. Clinical tests that more profoundly evaluate the therapeutic potential of this drug in this type of patients are required. (C) 2010 AEU. Published by Elsevier Espana, S.L. All rights reserved.

Introducciónlas opciones terapéuticas en las pacientes con vejiga dolorosa asociada a cistitis intersticial están poco estudiadas. Se pretende verificar la seguridad y eficacia del tratamiento con hialuronato de sodio a través de instilación intravesical en pacientes portadoras de síndrome de vejiga dolorosa.Material y métodosse presenta una serie de 18 pacientes femeninas, con edad media de 51 años y diagnóstico previo de síndrome de vejiga dolorosa, que fueron tratadas mediante la infusión de una solución intravesical semanal de 40mg de hialuronato de sodio en solución estéril, durante 8 semanas. Las pacientes fueron evaluadas clínica y urodinámicamente antes de su inclusión en el estudio y 8 meses después de haber finalizado las instilaciones.Resultadosse observó una mejora estadísticamente significativa en los parámetros urodinámicos y en la sintomatología medida cuantitativamente mediante el cuestionario Pelvic Pain and Urgency/Frequency entre la situación basal y después de la instilación vesical de hialuronato de sodio en paciente con síndrome de vejiga dolorosa. La toxicidad derivada del tratamiento fue nula, puesto que no se registró efecto adverso relacionado con el tratamiento.Conclusiónse demuestra la utilidad clínica del ácido hialurónico intravesical en pacientes con síndrome de vejiga dolorosa posiblemente asociado a cistitis intersticial. La mejoría clínica se asocia también con aumento de la capacidad y mejora de la sensibilidad vesical. La tolerancia fue excelente. Se necesitan ensayos clínicos que evalúen en profundidad el potencial terapéutico de este fármaco en este tipo de pacientes.

Introduction and objective: During pregnancy, hormonal change, increase in the body mass index and the pressure caused by the enlarged uterus over the bladder and pelvic floor, are some factors involved in lower urinary tract symptoms (LUTS). This study was made to evaluate the correlation between pregnancy and delivery way with LUTS.Material and method: This open prospective study was carried out using the overactive bladder questionnaire short form (OABq-SF). A total of 60 patients enrolled this study. The mean age was 24 year, raging from 14 to 40 years. The patients were evaluated during the third trimester and 6 months after delivery. Statistical analysis of the OABq-SF scores was made using the Pearson method.Results: Mean OABq-SF score during pregnancy was 35.2 and 6 months after delivery decreased to15. Quality of life was 82.9 during pregnancy and increased to 88.4 at 6 month after delivery. Patient's perception, that is correlation, was 55.02 (p=0.0001) during pregnancy and 36.1% (p=0.0046). Clinical correlation index was 6.7%.Conclusions: Our study demonstrated that in spite of LUTS being more important during pregnancy, there is no significant clinical correlation in patient's perception. (C) 2010 AEU. Published by Elsevier Espana, S.L. All rights reserved.

Objetivos: se realizó un estudio prospectivo para evaluar la eficacia de la fijación de la cúpula vaginal al ligamento sacroespinoso, y la repercusión sobre el compartimento anterior.Se utilizó, el sistema (POP-Q) para cuantificar el prolapso de órganos pélvicos del compartimento vaginal: apical y anterior.Métodos: cincuenta y ocho pacientes fueron sometidas al procedimiento de corrección del prolapso apical entre marzo del 2003 y febrero del 2006.La media de puntuación de POP-Q en el preoperatorio y postoperatorio varió, respectivamente: Aa (+0,74; -1,45); Ba (+3,17; -1,36), C (+3,41; -7,71); (p < 0,001).Resultados: la tasa de curación fue del 93,1%.La evaluación del compartimiento anterior de la vagina en el preoperatorio y postoperatorio fue respectivamente: etapa 1 (5,2%; 48,3%), etapa 2 (6,9%; 34,5%), etapa 3 (74,1%; 5,2%) y etapa 4 13,8%; 0%).El cistocele se produjo de novo en el 87,9%.Hubo mejoría de los síntomas del tracto urinario, como urgencia, nocturia e incontinencia de urgencia.Conclusiones: la suspensión al ligamento sacroespinoso de la cúpula vaginal, es efectiva en el tratamiento del prolapso apical y determina la formación de cistocele en la mayoría de los casos.

OBJECTIVES:A prospective study was conducted to assess the efficacy of sacrospinous vaginal vault fixation and its impact on the anterior compartment. The Pelvic Organ Prolapse Quantification (POP-Q) system was used to quantify pelvic organ prolapse in the apical and anterior vaginal compartments. METHODS:Fifty-eight patients underwent a procedure to correct apical prolapse from March 2003 to February 2006. Mean preoperative and postoperative POP-Q scores were respectively: Aa (+0.74; -1.45); Ba (+3.17; -1.36); C (+3.41; -7.71) (p<0.001). RESULTS:Cure rate was 93.1%. Preoperative and postoperative evaluation of the anterior vaginal compartment was respectively: stage 1 (5.2%; 48.3%), stage 2 (6.9%; 34.5%), stage 3 (74.1%; 5.2%), and stage 4 (13.8%; 0%). De novo cystocele occurred in 87.9% of cases. An improvement was seen in lower urinary tract symptoms of urgency, nocturia, and urge incontinence. CONCLUSIONS:Sacrospinous vaginal vault suspension is effective for the treatment of apical prolapse and leads to formation of cystocele in most cases.

INTRODUCTION AND OBJECTIVE:During pregnancy, hormonal change, increase in the body mass index and the pressure caused by the enlarged uterus over the bladder and pelvic floor, are some factors involved in lower urinary tract symptoms (LUTS). This study was made to evaluate the correlation between pregnancy and delivery way with LUTS.MATERIAL AND METHOD:This open prospective study was carried out using the overactive bladder questionnaire short form (OABq-SF). A total of 60 patients enrolled this study. The mean age was 24 year, raging from 14 to 40 years. The patients were evaluated during the third trimester and 6 months after delivery. Statistical analysis of the OABq-SF scores was made using the Pearson method.RESULTS:Mean OABq-SF score during pregnancy was 35.2 and 6 months after delivery decreased to15. Quality of life was 82.9 during pregnancy and increased to 88.4 at 6 month after delivery. Patient's perception, that is correlation, was 55.02 (p=0.0001) during pregnancy and 36.1% (p=0.0046). Clinical correlation index was 6.7%.CONCLUSIONS:Our study demonstrated that in spite of LUTS being more important during pregnancy, there is no significant clinical correlation in patient's perception.

Pericervical ring is the Key stone of the genital support, when an apical defect is present, prolapse may occur in anterior and posterior compartments.

Rectoceles are usually associated with other genital prolapses. There are no conclusive data on its real incidence. The creation of utero-sacral neoligaments, decribed by Petros, evolved into a new procedure allowing for the anatomical reconstruction of the three levels proposed by DeLancey. The aim of this study is evaluate safety and efficacy as well the clinical outcome according to the level of the defects and its fixation point.