Rheumatoid arthritis [RA] is one of the most common and severe autoimmune rheumatic diseases, diagnosed primarily according to clinical manifestations and radiological reports. For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor [RF], as established by the ACR criteria. A recent test to detect antibodies towards citrullinated peptides, called the anti-CCP assay, showed a similar sensitivity but a more elevated specificity than the RF test. The direction of current therapies is to treat RA aggressively with early use of sequential or disease modifying anti rheumatic drugs (DMARDs). Here an attempt is made to review the existing physical and clinical methods to diagonise RA, therapeutical methods available and their drawbacks.
In this study, the wound healing activity of total aqueous extract and the mucilage of leaves of plant Cocculus hirsutus (L) Diels was evaluated on excision wound model. Dermal films were prepared using total aqueous extract, mucilage and polyvinyl alcohol as a polymer base. The prepared polysaccharide solutions of the total extract and the isolated mucilage were evaluated for its physiochemical properties and total bacterial count. The prepared dermal patches were subjected biodegradation studies. The results indicate statistically significant wound healing response of the dermal patch containing the aqueous extract and the mucilage of leaves of plant C. hirsutus when compared with control group and groups subjected to standard marketed medicated dermal patch. The cost effective factor and biodegradation of the prepared dermal wound healing patch was also found to be significant.
The methanol extracts of Mahonia leschenaultii takeda (Berberidaceae) root and root bark were tested for antibacterial potential against Escherichia coli (NCIM 2068), Pseudomonas aeruginosa (NCIM 2053), Staphylococcus aureus (NCIM 2492), and Staphylococcus epidermitis (NCIM 2493) on nutrient agar medium and nutrient broth using ampicillin trihydrate as standard drug. For antifungal study, stains used were Trichophytons lignorum (NCIM 1195) and Candida crusei (NCIM 3129) on Sabourauds dextrose agar (SDA) and Sabourauds dextrose broth (SDB) by cup plate method using amphotericin B as standard drug. The results showed that all extracts exhibited significant activity against all the selected strains of bacteria and relatively more against Staphylococcus epidermitis . The antifugal activity was less significant when compared with antibacterial activity.
The methanol extracts of Mahonia leschenaultii takeda (Berberidaceae) root and root bark were tested for antibacterial potential against Escherichia coli (NCIM 2068), Pseudomonas aeruginosa (NCIM 2053), Staphylococcus aureus (NCIM 2492), and Staphylococcus epidermitis (NCIM 2493) on nutrient agar medium and nutrient broth using ampicillin trihydrate as standard drug. For antifungal study, stains used were Trichophytons lignorum (NCIM 1195) and Candida crusei (NCIM 3129) on Sabourauds dextrose agar (SDA) and Sabourauds dextrose broth (SDB) by cup plate method using amphotericin B as standard drug. The results showed that all extracts exhibited significant activity against all the selected strains of bacteria and relatively more against Staphylococcus epidermitis . The antifugal activity was less significant when compared with antibacterial activity.
