Australian and New Zealand Journal of MedicineVolume 10, Issue 1 p. 129-129 MORPHOLOGIC, MORPHOMETRIC AND FUNCTIONAL STUDIES IN ISCHAEMIC ACUTE RENAL FAILURE IN THE RAT Roy A. Axelsen, Roy A. Axelsen Department of Pathology, University of QueenslandSearch for more papers by this authorVeronica E. Cartwright, Veronica E. Cartwright Department of Pathology, University of QueenslandSearch for more papers by this author Roy A. Axelsen, Roy A. Axelsen Department of Pathology, University of QueenslandSearch for more papers by this authorVeronica E. Cartwright, Veronica E. Cartwright Department of Pathology, University of QueenslandSearch for more papers by this author First published: February 1980 https://doi.org/10.1111/j.1445-5994.1980.tb03498.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume10, Issue1February 1980Pages 129-129 RelatedInformation

Australian and New Zealand Journal of MedicineVolume 10, Issue 1 p. 130-130 ANALGESIC-INDUCED RENAL PAPILLARY NECROSIS AND SALICYLATE METABOLISM IN THE GUNN RAT Roy A. Axelsen, Roy A. Axelsen Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorFelix Bochner, Felix Bochner Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorVeronica E. Cartwright, Veronica E. Cartwright Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorDebra M. Imhoff, Debra M. Imhoff Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorBill E. Cham, Bill E. Cham Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this author Roy A. Axelsen, Roy A. Axelsen Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorFelix Bochner, Felix Bochner Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorVeronica E. Cartwright, Veronica E. Cartwright Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorDebra M. Imhoff, Debra M. Imhoff Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this authorBill E. Cham, Bill E. Cham Departments of Pathology and Medicine, University of QueenslandSearch for more papers by this author First published: February 1980 https://doi.org/10.1111/j.1445-5994.1980.tb03501.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume10, Issue1February 1980Pages 130-130 RelatedInformation

Unilateral post-ischaemic acute renal failure (ARF) was produced in rats by occluding the left renal artery and vein for one hour. Left renal function was assessed 1 or 2 h after the end of the period of ischaemla and the kidneys fixed by arterial perfusion. ARF was characterized by increased urine flow (8.1 ± 1.2 SEM μl/min/100 g body weight, n = 14; controls 1.0 ± 0.1, n = 11), decreased urinary osmolality (335 ± 12 m Osm/kg, n = 14; controls 1885 ± 97, n = 11), and markedly reduced 3H inulin urine/plasma ratio (3.98 ± 0.56, n = 14; controls 499 ± 60, n = 9) and 3H inulin clearance (32.9 ± 7.0 μl/min/100 g body weight, n = 14; controls 505 ± 45, n = 9). Renal cortical blood flow, determined by the hydrogen desaturation technique, was less in animals with ARF (4.2 ± 0.4 ml/min/ml of cortex, n = 8) than in controls (5.4 ± 0.6, n = 5), but not significantly so. In vivo stereomicroscopic examination of the left renal surface in ARF revealed dilated proximal convoluted tubules and delayed passage of intravenously injected dye (lissamine green) through these tubules. Histological examination also showed dilated proximal convoluted tubules and cellular debris impacted in the terminal straight portions of proximal tubules and thin limbs of the loops of Henle. Light microscopic morphometric studies demonstrated significant dilatation of proximal convoluted tubules and Bowman’s spaces, and significant narrowing of the lumina of distal convoluted tubules and cortical collecting ducts. The data support the pathogenetic significance of tubular obstruction in a polyuric model of ischaemic ARF in the absence of a marked decrease in renal cortical blood flow, and demonstrate the value of morphometric studies in experimental ARF. The usefulness of the hydrogen desaturation technique for the determination of renal cortical blood flow, reported herein for the first time in ischaemic ARF, is emphasized.