Crohn’s disease-associated perianal fistulas (PFCD) and Cryptoglandular anal fistulas (CAF) are two types of fistulas with similar clinical manifestations but distinct etiologies and therapeutic strategies. This study aims to investigate serum amino acid metabolic profiles in patients with CAF and PFCD based on UPLC-MS/MS. Serum samples were enrolled from newly diagnosed and treatment-naïve 36 patients with active PFCD and 36 patients with CAF as controls. Clinical characteristics were systematically documented. Serum concentrations of 25 amino acids were quantitatively determined using UPLC-MS/MS with isotopically labeled internal standards. Multivariate statistical analyses were employed to discriminate metabolic profiles between groups. Pathway enrichment analysis of differential amino acids was performed using Metabo Analyst 5.0. The PFCD cohort exhibited significantly lower total serum amino acid concentrations compared to CAF group, with 13 differentially expressed amino acids identified. Multivariate analyses revealed a significant separation trend between the two groups, eight amino acids were prioritized as candidate diagnostic biomarkers. Metabolic pathway enrichment analysis demonstrated that five pathways showed significant associations with metabolic disparities between the two groups. The proposed biomarker panel may assist in differentiating PFCD from CAF and guide individualized therapy.

This study aimed to explore the immediate effects of transcutaneous electrical nerve stimulation (TENS) on localized masticatory muscle mechanical hyperalgesia, jaw-muscle activation, and mandibular movement measures in individuals with probable bruxism but without DC/TMD-defined painful TMD, compared with sham TENS. Forty participants (7 men, mean age: 25.6 years; 33 women, mean age: 23.6 years) classified as having probable bruxism and presenting with localized masticatory muscle mechanical hyperalgesia were randomly assigned to TENS/sham TENS (sTENS) treatment groups, using a randomized and double-blind design with 20 participants in each group. TENS or sham TENS was applied once. TENS was delivered using rectangular pulse current waveforms, with the output current set above the sensory threshold, for 30 min. The primary pain-sensitivity outcomes were the immediate changes in pressure pain threshold (PPT) at the masseter and temporalis sites from baseline to post-treatment. Thenar PPT was assessed as a remote reference site and was not considered a primary outcome. Secondary exploratory outcomes included mandibular movement measures and electromyography (EMG) activity of the masseter and temporalis muscles during MRP and MCE tasks. Because the study was exploratory, the secondary outcomes should be interpreted cautiously. Baseline data revealed no significant differences between the two groups before treatment. Within-group comparisons showed that, after intervention the TENS group showed increased PPT values (masseter, p = 0.003; temporalis, p = 0.002), decreased EMG activity during mandibular rest position (MRP) (masseter, p = 0.003; temporalis, p = 0.004), increased EMG activity during maximum clenching effort (MCE) on 10-mm cotton rolls (p = 0.003). In contrast, the sTENS group showed no significant pre-to-post changes in these outcomes (PPT: masseter, p = 0.422; temporalis, p = 0.266) (EMG at MRP: masseter, p = 0.553; temporalis, p = 0.539). Two-way mixed-design ANOVA revealed significant time × treatment interactions for masseter PPT (p = 0.007), masseter EMG activity during MRP (p = 0.011), and maximum opening distance (p = 0.004). Temporalis PPT showed a significant main effect of time but no significant time × treatment interaction. Post-hoc comparisons indicated greater increases in masseter PPT and greater reductions in masseter EMG activity during MRP in the TENS group than in the sham TENS group. Maximum opening distance was interpreted cautiously as a secondary exploratory finding. In this proof-of-concept study, a single session of TENS was associated with immediate increases in masseter PPT and changes in selected EMG and mandibular movement measures in individuals with probable bruxism and localized masticatory muscle mechanical hyperalgesia but without DC/TMD-defined painful TMD. These results support further investigation of repeated TENS sessions and longitudinal follow-up in this specific subclinical phenotype. The present study does not establish whether TENS modifies bruxism activity or prevents the development of painful temporomandibular disorders. Chinese Clinical Trial Registry ChiCTR2400086817, registered on July 11, 2024. Retrospectively registered.

The current study aims to comprehensively evaluate the surgical impact on anal function in pediatric patients with anal fistulas, incorporating anorectal manometry, histopathological examination, and various rating scales. The study focuses on infants and toddlers diagnosed with anal fistulas who underwent surgical intervention at Longhua Hospital, Shanghai University of Traditional Chinese Medicine, between November 2020 and January 2024. The participants were divided into two age cohorts: infants (0–12 months) and toddlers (13–36 months). Data were meticulously collected for both cohorts, with anal function assessed through intraoperative anorectal manometry, Masson staining of fistula tissue, and the Heikkinen clinical continence scoring (CCS) scale during the postoperative period (1) Both cohorts demonstrated a 100

Bitcoin mixing operations are commonly used to enhance transaction privacy by obscuring the connection between inputs and outputs. However, current methods have drawbacks such as relying on trusted third parties, being susceptible to rogue key attacks, and inefficiency. To tackle these issues, our paper introduces a decentralized Bitcoin mixing scheme CoinMixMultiSig (CMMS), which enables participants to collaborate in generating a public address. This scheme employs a two-round public address generation process, wherein all participants send bitcoins to the jointly generated addresses before signing them to prevent fraud. Additionally, CMMS utilizes a multi-signature mechanism that not only reduces the size of signatures but also significantly improves the system’s scalability.

Aim: This study was conducted to test segmental and extra-segmental temporal summation (TS) effects of repetitive mechanical stimulation in patients with painful temporomandibular joints (TMJ) and healthy individuals. Methods: Twenty patients with unilateral pain in the TMJ and 20 gender- and age-matched healthy controls were included. A modified Quantitative Sensory Testing (QST) protocol was performed including pressure pain thresholds (PPT), mechanical pain thresholds (MPT), and numerical rating scale (NRS) scores of TS effects of 10 repeated 0.5 kg, 1.0 kg pressure stimuli and pinprick stimuli were determined as wind-up ratios (WUR) on the glabrous skin of the dominant hand (extra-segmental) and bilaterally in the TMJ region. Kruskal-Wallis test was used for data analysis. Results: The PPT and MPT were significantly lower on painful TMJs compared to non-painful TMJs (P=0.001) and control TMJs (P=0.001). WUR of repetitive mechanical stimulation on painful TMJs was higher compared to control TMJs (P ≤ 0.012). Non-painful TMJs also had significantly higher WUR of pinprick stimuli compared to control TMJs (P=0.008). Except the WUR of repetitive mechanical stimulation (P=0.030) no significant differences were detected at the hand for any of the test parameters between the two groups (P ≥ 0.05). Conclusion: Patients with unilateral TMJ pain have segmentally, but not extra-segmentally, increased sensitivity to mechanical stimuli including facilitated temporal summation mechanisms at segmental as well at extra-segmental sites.

BACKGROUND:Empirical research has consistently documented the concurrent manifestation of frailty and chronic kidney disease (CKD). However, the existence of a reverse causal association or the influence of confounding variables on these correlations remains ambiguous. METHODS:Our analysis of 7,078 participants from National Health and Nutrition Examination Survey(NHANES) (1999-2018) applied weighted logistic regression and Mendelian Randomization (MR) to investigate the correlation between the frailty index (FI) and renal function. The multivariate MR analysis was specifically adjusted for type 2 diabetes and hypertension. Further analysis explored 3282 plasma proteins to link FI to CKD. A two-step network MR highlighted immune cells' mediating roles in the FI-CKD relationship. RESULT:Genetically inferred FI and various renal function markers are significantly correlated, as supported by NHANES analyses. Multivariate MR analysis revealed a direct causal association between the FI and CKD. Additionally, our investigation into plasma proteins identified Tmprss11D and MICB correlated with FI and CKD, respectively. A two-step network MR to reveal 15 immune cell types, notably Central Memory CD4+ T cells and Lymphocytes, as crucial mediators between FI and CKD. CONCLUSION:Our work establishes a causal connection between frailty and CKD, mediated by specific immune cell profiles. These findings highlight the importance of immune mechanisms in the frailty-CKD interplay and suggest that targeting shared risk factors and immune pathways could improve management strategies for these conditions. Our research contributes to a more nuanced understanding of frailty and CKD, offering new avenues for intervention and patient care in an aging population.

Renal hypoxia is a key factor in the progression of chronic kidney disease (CKD), yet it is challenging to evaluate non-invasively. This study utilized Blood Oxygenation Level-Dependent (BOLD) MRI to assess renal oxygenation and function in CKD patients and healthy volunteers (HVs). We retrospectively analyzed BOLD MRI data from 128 CKD patients and 25 HVs. CKD patients were categorized into mild (CKD stages 1-2), moderate (stage 3), and severe (stages 4-5) impairment groups based on their estimated glomerular filtration rate (eGFR). The study measured cortical and medullary T2* values (COT2* and MET2*), investigating their differences and correlations with eGFR and clinical indicators such as serum creatinine (Scr), cystatin C (Cys C), beta-2 microglobulin (β2-MG), and blood urea nitrogen (BUN). Our findings indicated that both COT2* and MET2* values were significantly higher in HVs than in all CKD groups and decreased progressively with advancing CKD (P < 0.001). Notably, the decrease in T2* values correlated significantly with worsening renal function, evidenced by positive correlations with clinical indicators such as Scr, Cys C, β2-MG, and BUN (all P < 0.001), and negative correlations with eGFR (P < 0.001). No significant correlations were found between T2* values and UA (P > 0.05). Receiver operating characteristic (ROC) analysis further refined the clinical utility of BOLD MRI, identifying optimal cut-points for differentiating between stages: COT2* values were 62.25 ms between HVs and CKD stages 1-2, 52.58 ms between CKD stages 1-2 and 3, and 42.76 ms between CKD stages 3 and 4-5; MET2* values were 36.17 ms, 29.42 ms, and 23.33 ms, respectively, for these comparisons.This study highlights BOLD MRI's potential for non-invasively monitoring renal hypoxia and functional deterioration in CKD, advocating its integration into clinical diagnostics.

Introduction: Chronic hypoxia is prevalent in chronic kidney disease (CKD), and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) provides noninvasive evaluation of renal oxygenation. This study aimed to explore the correlation of renal oxygenation evaluated by BOLD-MRI with renal function. Methods: 97 non-dialysis patients with CKD stages 1–5 and healthy volunteers (HVs) were recruited in the study, all participants without diabetes. Based on their estimated glomerular filtration rate (eGFR), the patients were divided into two groups: CKD stages 1–3 (CKD 1–3) and CKD stages 4–5 (CKD 4–5). We measured cortical and medullary T2* (COT2* and MET2*) values in all participants by BOLD-MRI. Physiological indices were also recorded and compared among three groups. Correlation of T2* values with clinical characteristics was determined. Results: The COT2* values were significantly higher than MET2* values in all participants. The COT2* and MET2* values of three groups were ranked as HV > CKD 1–3> CKD 4–5 (p < 0.0001). There were positive correlations between the COT2* values, MET2* values and eGFR, hemoglobin (r > 0.4, p < 0.01). The 24-h urinary protein (24-h Upr) showed weak correlation with the COT2* value (rs = −0.2301, p = 0.0265) and no correlation with the MET2* value (p > 0.05). Urinary microprotein, including urinary alpha1-microglobulin, urinary beta2-microglobulin (β2-MG), and urinary retinol-binding protein (RBP), showed strong correlation with COT2* and MET2* values. According to the analysis of receiver operating characteristic curve, the optimal cut-points between HV and CKD 1–3 were “<61.17 ms” (sensitivity: 91.23%, specificity: 100%) for COT2* values and “<35.00 ms” (sensitivity: 77.19%, specificity: 100%) for MET2* values, whereas COT2* values (“<47.34 ms”; sensitivity: 90.00%, specificity: 92.98%) and MET2* values (“<25.09 ms”; sensitivity: 97.50%, specificity: 80.70%) between CKD 1–3 and CKD 4–5. Conclusion: The decline of renal oxygenation reflected on T2* values, especially in cortex, may be an effective diagnostic marker for early detection of CKD.

Background Some Chinese scholars have initially explored the efficacy of electroacupuncture at Baliao acupoint in patients with functional anorectal pain (FAP). However, their studies are performed in a single center, or the sample size is small. Therefore, we aim to further explore the efficacy of electroacupuncture at Baliao acupoint on the treatment of FAP.Methods In this multicenter randomized controlled trial, 136 eligible FAP patients will be randomly allocated into an electroacupuncture group or sham electroacupuncture group at a 1:1 ratio. This trial will last for 34 weeks, with 2 weeks of baseline, 4 weeks and 8 weeks of treatment, and 1, 3, and 6 months of follow-up. Outcome assessors and statisticians will be blind. The primary outcome will be clinical treatment efficacy, and secondary outcomes will be pain days per month, quality of life, psychological state assessment, anorectal manometry, pelvic floor electromyography, and patient satisfaction.Discussion Results of this trial will be contributed to further clarify the value of electroacupuncture at Baliao acupoint as a treatment for FAP in the clinic.Trial registration This trial has been registered in Chinese Clinical Trial Registry https://www.chictr.org.cn/ (ChiCTR2300069757) on March 24, 2023.

ETHNOPHARMACOLOGICAL RELEVANCE:The clinical efficacy of the Yiqi Kaimi prescription has been confirmed in slow transit constipation. However, the effects and biological mechanism of Yiqi Kaimi prescription are still unclear.AIMS OF THE STUDY:To identify the effects of Yiqi Kaimi prescription on intestinal motility; To reveal the potential key targets and pathways of Yiqi Kaimi prescription for the treatment of slow transit constipation.MATERIALS AND METHODS:The effects of Yiqi Kaimi prescription on slow transit constipation were investigated in a mouse model. The terminal ink propulsion experiment and fecal indocyanine green imaging was used to measure the intestinal transit time. Protein phosphorylation changes in colon tissues treated with Yiqi Kaimi prescription were detected using a Phospho Explorer antibody microarray. Bioinformatic analyses were performed using the Database for Annotation Visualization and Integrated Discovery (DAVID) and the Search Tool for the Retrieval of Interacting Genes (STRING). Western blot analysis and immunohistochemistry confirmed the observed changes in phosphorylation.RESULT:s: Yiqi Kaimi prescription significantly increased the intestinal transit rate (P < 0.05 vs. model) and reduced the time to first discharge of feces containing fecal indocyanine green imaging in mice (P < 0.05 vs. model). The administration of Yiqi Kaimi prescription induced phosphorylation changes in 41 proteins, with 9 upregulated proteins and 32 downregulated proteins. Functional classification of the phosphorylated proteins with DAVID revealed that the critical biological processes included tyrosine protein kinases, positive regulation of calcium-mediated signaling and response to muscle stretch. The phosphorylation of the spleen tyrosine kinase (SYK) at Tyr348 increased 2.19-fold, which was the most significant change. The phosphorylation level of the transcription factor p65 (RELA) at Thr505 was decreased 0.57-fold. SYK was a hub protein in the protein-protein interaction network and SYK and RELA formed the core of the secondary subnetwork. The key protein phosphorylation after treatment with Yiqi Kaimi prescription were verified by Western blot analysis and immunohistochemistry.CONCLUSION:Yiqi Kaimi prescription significantly enhanced intestinal motility. This effect was attributed to alterations in the phosphorylation levels of various target proteins. The observed changes in protein phosphorylation, including SYK and RELA, may serve as crucial factors in the treatment of slow transit constipation.

Cardiorenal syndrome (CRS) is a multifaceted relationship between the heart and kidney, where acute kidneys injury (AKI) directly contributes to cardiac dysfunction. The present study aimed to explore the changes of early transcriptome in heart exposed AKI via a mouse unilateral ureteral obstruction (UUO) model. This study was designed to extract differentially expressed genes (DEGs) and their implicated biological processes as well as pathways from the GSE235751 dataset of high-throughput gene expression profile via bioinformatics tools. Preprocessing-introduction of Data was undergone for data integrity and quality check, Differential expression analysis that identified significant gene expressions changes in heart tissue associated with AKI. Pathway analysis and functional annotation revealed involvement of inflammation, cardiac repair, mitochondrial function and autophagy as the major pathways influencing differences in gene expression. Between unrelated groups, validation of distinctly expressed genes was performed using Principal Component Analysis (PCA) and t-Distributed Stochastic Neighbor Embedding (t-SNE). Gene Set Enrichment Analysis (GSEA) showed downregulation of mitochondrial oxidative bioenergetics and autophagy, while upregulating cell proliferation inflammation pathways. These results indicate that AKI induces robust changes in cardiac gene expression, affecting many different pathways and provide novel information about the molecular mechanisms underlying CRS. These results identify possible early intervention and therapeutic targets for the better understanding and treatment of CRS.

目的:基于网络药理学探究沉香治疗缺氧性肾损伤的潜在机制.方法:通过TCMSP数据库筛取沉香活性组分及作用靶点;从GeneCards、OMIM、TTD、DrugBank数据库获取肾缺氧相关靶点,利用String平台构建PPI网络并挖掘潜在蛋白质功能模块.Metascape平台分析所涉及的生物过程及通路,Cytoscape 3.8.2软件构建"沉香成分—肾脏缺氧靶点—通路"网络,Autodock软件进行分子对接验证.结果:沉香改善肾脏缺氧的核心成分包括槲皮素、β-谷甾醇、6,7-二甲氧基-2-(苯乙基)色酮等,核心靶点有BAX、IL6、AKT1、BCL2、TP53等,对接结果中Affinity小于-5者占93.3％,提示靶点和成分间较好的结合活性.关键靶点主要富集于AGE-RAGE信号通路、流体剪切应力与动脉粥样硬化通路、HIF-1信号通路以及p53信号通路等20个显著相关通路,涉及细胞凋亡、炎症反应、免疫调节、缺氧及氧化应激等100多个显著相关生物学过程.结论:本研究初步探析了沉香治疗缺氧性肾损伤的潜在机制,为沉香在肾脏疾病中的应用提供科学依据.

Driven by artificial intelligence and network communication technology, intelligent 6G wireless systems have gradually become an important environment for users to enjoy data services in the future. However, edge computing enabled 6G wireless systems still have some open issues on the searchability of outsourced data and security of user information. In this paper, a multidimensional storage structure with encrypted is proposed for data with various categories in intelligent 6G wireless systems. A two-tuple storage table is utilized to compress the block location matrix of the storage structure. Additionally a searchable and secure edge pre-cache scheme is proposed. Edge nodes cache the data requested by the user in advance according to the user’s location and direction. The users in the novel scheme are proved to be unforgeable and anonymous. The experiments show that the scheme is efficient on the user side and the time cost of the edge node indicates that the scheme is low latency.

目的:观察肾衰Ⅱ号方颗粒联合恩格列净对慢性肾脏病(CKD)2～3 期患者蛋白尿和肾功能的影响.方法:纳入脾肾两虚、湿浊瘀阻证CKD 2～3 期患者60 例,随机分为对照组30 例和治疗组30例.两组患者均予西医一体化治疗,在此基础上,对照组患者予安慰剂颗粒联合恩格列净治疗,治疗组患者予肾衰Ⅱ号方颗粒联合恩格列净治疗,疗程为3 个月.治疗后,评价并比较两组患者的临床疗效及中医证候疗效;治疗前后,检测并比较两组患者的血肌酐(Scr)、血尿酸(UA)、血尿素氮(BUN)、肾小球滤过率估计值(eGFR)及24 h 尿蛋白定量(24 h Upro)水平.结果:①治疗后,对照组的临床疗效总有效率为56.67％,治疗组为86.67％,治疗组的疗效显著优于对照组(P＜0.05).②治疗后,对照组的中医证候疗效总有效率为56.67％,治疗组为83.33％,治疗组的中医证候疗效显著优于对照组(P＜0.05).③治疗后,两组患者的Scr、UA、24h Upro水平较治疗前均明显降低(P＜0.05),eGFR水平明显升高(P＜0.05),治疗组患者的BUN 水平亦明显降低(P＜0.05),且治疗组患者的Scr水平显著低于对照组(P＜0.05)、cGFR水平显著高于对照组(P＜0.05).结论:肾衰Ⅱ号方颗粒联合恩格列净可更好地改善脾肾两虚、湿浊瘀阻证CKD 2～3期患者的中医证候和肾功能,提高临床疗效,具有较好的肾脏保护作用.

直肠肛管周围脓肿是以肛周局部肿痛为主要症状的急性化脓性感染性疾病,多因肛腺阻塞或感染继发产生炎症反应后[1],经括约肌间向周围其他组织间隙侵犯所致.根据脓肿所侵犯的位置主要将其分为肛门周围脓肿、坐骨直肠间隙脓肿、肛门括约肌间脓肿、骨盆直肠间隙脓肿等.

Automation systems are soaring due to the innovation of artificial intelligence (AI) technologies. In this paper, we mainly concentrate on the security and efficiency of data transmission in AI-based automation systems, especially, for data sharing in a group manner in distributed networks. To this end, an authenticated group key agreement protocol is proposed for secure data transmission in AI-based automation systems. In order to release the computational overhead of distributed nodes, a semi-trusted authority (STA) is introduced to enable precomputation operations. Moreover, to overcome the predominantly distributed denial of service (DDoS) attack, a dynamic batch verification mechanism is devised. The presented dynamic batch verification mechanism guarantees that the proposed protocol can be run properly among legitimate nodes regardless of the existence of nodes who suffered from the DDoS attack. Finally, the session key security of the proposed protocol is proved and the performance is evaluated.

Objective It is to evaluate the clinical efficacy of binding therpay combined with Chinese herbs for supplementing qi and nourishing yin in the treatment of rectocele constipation with syndrome of deficiency of both qi and yin. Methods Seventy-four patients with rectocele constipation with syndrome of deficiency of both qi and yin who visited the Anorectal Clinic of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2020 to December 2021 were randomly divided into two groups. The treatment group（n=37） was treated with binding surgery combined with Chinese herbs for supplementing qi and nourishing yin, and the control group（n=37） was treated with biofeedback therapy combined with Chinese herbs for supplementing qi and nourishing yin. 28 days as 1 course of treatment, and both groups were treated for 1 course of treatment. The duration of defecation, the number of hand-assisted defecation per week, the scores of obstructive defecation syndrome（ODS） scale and the score of traditional Chinese medical symptoms were recorded before and after treatment for 7, 14, 28, 90 days. The clinical efficacy of the 2 groups was evaluated. Results After 7, 14, 28, and 90 days of treatment, the defecation times of both groups were significantly shorter than those before treatment, and the numbers of hand-assisted defecation per week were less than those before treatment, the ODS scores and traditional Chinese medical syndrome scores were significantly lower than those before treatment, and the differences were all statistically significant（all P＜0.05）. The defecation time was significantly shorter, the numbers of hand-assisted defecation per week was more, the ODS scores were and traditional Chinese medical syndrome scores were lower than those in the control group at each time point, and the differences were all statistically significant（all P＜0.05）. The total effective rates of traditional Chinese medicine syndrome in both groups were both 97.3%（36/37）, and the cure rate in the treatment group was 13.51%（5/37）, which was significantly higher than that in the control group, the therapeutic effect of the treatment group was better than that of the control group（P＜0.05）. Conclusion Binding combined with invigorating qi and nourishing yin herbs can shorten the defecation time, reduce the frequency of hand-assisted defecation, and improving outlet obstruction syndrome and improving Chinese medical syndromes in patients with rectocele constipation with syndrome of deficiency of both qi and yin.

Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy. Therefore, an in-depth study of cardiac heterogeneity and cell-to-cell interactions can help elucidate the pathogenesis of diabetic myocardial fibrosis and identify treatment targets for the treatment of this disease. In this study, we investigated intercellular communication drivers of myocardial fibrosis in mouse heart with high-fat-diet/streptozotocin-induced diabetes at single-cell resolution. Intercellular and protein–protein interaction networks of fibroblasts and macrophages, endothelial cells, as well as fibroblasts and epicardial cells revealed critical changes in ligand–receptor interactions such as Pdgf(s)–Pdgfra and Efemp1–Egfr, which promote the development of a profibrotic microenvironment during the progression of and confirmed that the specific inhibition of the Pdgfra axis could significantly improve diabetic myocardial fibrosis. We also identified phenotypically distinct Hrchi and Postnhi fibroblast subpopulations associated with pathological extracellular matrix remodeling, of which the Hrchi fibroblasts were found to be the most profibrogenic under diabetic conditions. Finally, we validated the role of the Itgb1 hub gene-mediated intercellular communication drivers of diabetic myocardial fibrosis in Hrchi fibroblasts, and confirmed the results through AAV9-mediated Itgb1 knockdown in the heart of diabetic mice. In summary, cardiac cell mapping provides novel insights into intercellular communication drivers involved in pathological extracellular matrix remodeling during diabetic myocardial fibrosis.

IgA肾病是临床难治性免疫相关性肾小球疾病,发病机制尚未明确,因此缺乏特异性治疗方法.中医辨证论治的优势在于通过改善IgA肾病患者体质状态,控制诱发加重因素,阻断病程迁延发展,保护肾脏功能,从而改善患者预后,具有积极的临床意义.本文基于玄府理论,认为肺脾肾"玄府郁闭"是IgA肾病的核心病机,立"开玄通府"治疗原则,以补虚固玄、祛风开玄、除湿开玄、化瘀开玄为法,以期为临床治疗IgA肾病提供新思路.

The various data collected by urban sensor devices need a huge storage space. The cloud’s powerful calculation ability provides decent performance support and reduces the overhead on local storage. There are many kinds of data collected by urban sensor devices, and the same kind of sensors often need to upload large numbers of files together, which are usually private, so secure cloud storage in group members is essential. However, the cloud may try to modify or hide data for its own benefit, which requires the detection of a third-party auditor. This paper puts forward a new public audit scheme. Some changes have been made to the way of generating the private key, the parameters of key generation come from the feature information set of the same sensor. When the two information sets are close enough, the correctness of the authenticator generated by this file can be verified. When the sensor is revoked due to damage or loss, this scheme will effectively revoke and regenerate the private key with less overhead, thus preventing the leakage of data privacy. This also avoids the huge overhead caused by re-downloading data to generate authenticators in traditional schemes. In addition, our scheme is effective in tracking malicious members and reducing the computing overhead of the group. Finally, the experimental results show the effectiveness and practicality of the proposed scheme.