IntroductionMultiple organ dysfunction syndrome (MODS) is common in patients with sepsistic admitted to an intensive care unit (ICU) and greatly increases mortality. Pancreatic stone protein/regenerating protein (PSP/Reg) is a type of C-type lectin protein that is overexpressed during sepsis. This study aimed to evaluate the potential involvement of PSP/Reg in MODS development in patients with sepsis. Materials and methodsThe relationship between circulating PSP/Reg levels, patient prognosis, and progression to MODS was analyzed in patients with sepsis admitted to the ICU of a general tertiary hospital. Furthermore, to examine the potential involvement of PSP/Reg in sepsis-induced MODS, a septic mouse model was established per the cecal ligation and puncture procedure, randomized into three groups, and subjected to a caudal vein injection of recombinant PSP/Reg at two different doses and phosphate-buffered saline. Survival analyses and disease severity scoring were performed to evaluate the survival status of the mice; enzyme-linked immunosorbent assays were performed to detect the levels of inflammatory factors and organ-damage markers in murine peripheral blood; terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was performed to measure apoptosis levels in lung, heart, liver, and kidney tissue sections and to visualize the degree of organ damage in the mouse model; myeloperoxidase activity assay, immunofluorescence staining, and flow cytometry were performed to detect neutrophil infiltration levels in vital murine organs and the activation indexes of neutrophils. Results and discussionOur findings indicated that Circulating PSP/Reg levels were correlated with patient prognosis and sequential organ failure assessment scores. Furthermore, PSP/Reg administration increased disease severity scores, shortened survival time, increased the TUNEL-positive staining rate, and increased the levels of inflammatory factors, organ-damage markers, and neutrophil infiltration in the organs. Neutrophils can be activated by PSP/Reg to an inflammatory state, both in vivo and in vitro, which is characterized by the increased levels of intercellular adhesion molecule 1 and CD29. ConclusionPatient prognosis and progression to MODS can be visualized by monitoring PSP/Reg levels upon ICU admission. Additionally, PSP/Reg administration in animal models exacerbates the inflammatory response and severity of multiorgan damage, which may be accomplished by promoting the inflammatory state of neutrophils.

Background:Acute lung injury (ALI) is associated with a high mortality rate; however, the underlying molecular mechanisms are poorly understood. The purpose of this study was to investigate the expression profile and related networks of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in lung tissue exosomes obtained from sepsis-induced ALI.Methods:A mouse model of sepsis was established using the cecal ligation and puncture method. RNA sequencing was performed using lung tissue exosomes obtained from mice in the sham and CLP groups. Hematoxylin-eosin staining, Western blotting, immunofluorescence, quantitative real-time polymerase chain reaction, and nanoparticle tracking analysis were performed to identify relevant phenotypes, and bioinformatic algorithms were used to evaluate competitive endogenous RNA (ceRNA) networks.Results:Thirty lncRNA-miRNA-mRNA interactions were identified, including two upregulated lncRNAs, 30 upregulated miRNAs, and two downregulated miRNAs. Based on the expression levels of differentially expressed mRNAs(DEmRNAs), differentially expressed LncRNAs(DELncRNAs), and differentially expressed miRNAs(DEmiRNAs), 30 ceRNA networks were constructed.Conclusion:Our study revealed, for the first time, the expression profiles of lncRNA, miRNA, and mRNA in exosomes isolated from the lungs of mice with sepsis-induced ALI, and the exosome co-expression network and ceRNA network related to ALI in sepsis.

Background: Ultrasound-guided rhombic intercostal block (RIB) is a novel regional block that provides analgesia for patients who have received video-assisted thoracoscopic surgery (VATS). The anesthetic characteristics of ultrasound-guided RIB with different concentrations of ropivacaine are not known. This research primarily hypothesizes that ultrasound-guided RIB, given in combination with the same volume of different concentrations of ropivacaine, would improve the whole quality of recovery-40 (QoR-40) among patients with VATS. Approaches: This double-blinded, single-center, prospective, and controlled trial randomized 100 patients undergoing VATS to receive RIB. One hundred patients who have received elective VATS and satisfied inclusion standards were fallen into four groups randomly: control group with no RIB and R0.2%, R0.3%, and R0.4%; they underwent common anesthesia plus the RIB with ropivacaine at 0.2%, 0.3%, and 0.4% in a volume of 30 ml. Outcomes: Groups R0.2%, R0.3%, and R0.4% displayed great diversities in the overall QoR-40 scores and QoR-40 dimensions (in addition to psychological support) by comparing with the control group (Group C) (p < 0.001 for all contrasts). Groups R0.3% and R0.4% displayed great diversities in the overall QoR-40 scores and QoR-40 dimensions (in addition to psychological support) by comparing with the R0.2% group (p < 0.001 for all contrasts). The overall QoR-40 scores and QoR-40 dimensions [physical comfort (p = 0.585)] did not vary greatly between Groups R0.3% and R0.4% (p > 0.05 for all contrasts). Groups R0.2%, R0.3%, and R0.4% showed significant differences in numerical rating scales (NRS) score region under the curve (AUC) at rest and on movement in 48 h when compared with the Group C (p < 0.001 for all contrasts). Groups R0.3% and R0.4% displayed great diversities in NRS score AUC at rest and on movement in 48 h when compared with the R0.2% group (p < 0.001 for all contrasts). The NRS mark AUC at rest and, on movement in 48 h, did not vary greatly between the Group R0.3% and R0.4% (p > 0.05 for all contrasts). Conclusion: In this study it was found that a dose of 0.3% ropivacaine is the best concentration for RIB for patients undergoing VATS. Through growing ropivacaine concentration, the analgesia of the RIB was not improved greatly. Clinicaltrials.gov Registration: https://clinicaltrials.gov/, identifier ChiCTR2100046254.

We would like to thank Luo and colleagues1Luo X. Xue F.S. Li C.W. Assessing early postoperative benefits of a nerve block: methodology is important.Ann Thorac Surg. 2022; 114: 2393-2394Abstract Full Text Full Text PDF Scopus (2) Google Scholar for their interest in our work2Deng W. Liu F. Jiang C.W. Sun Y. Shi G.P. Zhou Q.H. Continuous rhomboid intercostal block for thoracoscopic postoperative analgesia.Ann Thorac Surg. 2022; 114: 319-326Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar and for taking the time to provide helpful feedback. Recently, quality of recovery (QoR) scores, such as QoR-15 or QoR-40, were always used as the primary endpoint when assessing early postoperative benefits of a nerve block.3Altıparmak B. Korkmaz Toker M. Uysal A.I. et al.Evaluation of ultrasound-guided rhomboid intercostal nerve block for postoperative analgesia in breast cancer surgery: a prospective, randomized controlled trial.Reg Anesth Pain Med. 2020; 45: 277-282Crossref PubMed Scopus (34) Google Scholar,4Jung J. Jung W. Ko E.Y. et al.Impact of bilateral subcostal plus lateral transversus abdominis plane block on quality of recovery after laparoscopic cholecystectomy: a randomized placebo-controlled trial.Anesth Analg. 2021; 133: 1624-1632Crossref PubMed Scopus (11) Google Scholar First, postoperative pain is the main item of QoR scores, and it can significantly worsen the scoring of other items of QoR-15 or QoR-40, such as physical comfort, emotional status, and physical independence. Secondly, a perioperative nerve block can reduce the use of opioids and other analgesics, and thus reduce these related complications that will affect the quality of recovery scores. Therefore, compared with a single indicator of numerical rating scale (NRS) score, we believe that more indicators can assess the early postoperative benefits of a nerve block more accurately. A multimodal analgesia regimen is recommended for enhanced recovery after surgery protocols. Indeed, patients in the control group did not receive an optimal analgesic strategy because of lack of regional anesthesia for postoperative analgesia. Previous studies reported that some patients endured moderate to severe pain after video-assisted thoracoscopic surgery.5Okamoto A. Yamasaki M. Yokota I. et al.Classification of acute pain trajectory after breast cancer surgery identifies patients at risk for persistent pain:a prospective observational study.J Pain Res. 2018; 11: 2197-2206Crossref PubMed Scopus (34) Google Scholar,6Sun K. Liu D. Chen J. et al.Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: a retrospective study.Sci Rep. 2020; 10: 795Crossref PubMed Scopus (32) Google Scholar In this study, we aimed for an NRS score of resting ≤3. The pain degree increased significantly 12 hours postoperatively, mainly because it was the time in the small hours of the day, and the sense of pain degree increased, the same was seen in group continuous rhomboid intercostal block (CRIB). In group C, by giving rescue analgesia, the pain score of patients was controlled at roughly 3, and in order to reduce the side effects caused by analgesic-related drugs, the NRS score of movement was not perfectly controlled. In conclusion, we are very grateful to Luo and colleagues for their comments, and we will try to do better in the follow-up study. Assessing Early Postoperative Benefits of a Nerve Block: Methodology Is ImportantThe Annals of Thoracic SurgeryVol. 114Issue 6PreviewThe article in The Annals of Thoracic Surgery by Deng and colleagues,1 on determining the effects of ultrasound-guided continuous rhomboid intercostal block (CRIB) on the quality of recovery and postoperative analgesia after video-assisted thoracoscopic surgery, was of great interest. However, we noted 2 issues in methodology of this study that deserve further clarification. Full-Text PDF

BACKGROUND Rhomboid intercostal block is a type of plane block used for postoperative analgesia after video-assisted thoracoscopic surgery. This prospective randomized controlled trial was conducted to investigate the effects of ultrasound-guided continuous rhomboid intercostal block (CRIB) on the global Quality of Recovery (QoR-40) scores and postoperative analgesia after video-assisted thoracoscopic surgery. METHODS A total of 66 adult patients scheduled for elective unilateral video-assisted thoracoscopic surgery were randomly allocated to group C and group CRIB. In group C, patients were administered patient-controlled intravenous analgesia with sufentanil after operation. Patients in group CRIB received patient-controlled analgesia with ropivacaine CRIB. All patients completed the QoR-40 test during the preoperative evaluation and again 24 hours after the operation. Information on 48-hour postoperative pain and adverse events was recorded. RESULTS The QoR-40 scores of group C were significantly lower than the scores of group CRIB (155.4 +/- 6.1 vs 172.6 +/- 6.3; P<.001), with a mean difference of -17.2 (95% CI, -20.4 to -13.9) 24 hours after operation. The postoperative numeric rating scale scores in group CRIB at 6, 12, 18, and 24 hours after the surgical procedure, when patients were at rest, were significantly lower than the scores in group C (all P<.05). The postoperative numeric rating scale scores in group CRIB at 1, 3, 6, 12, 18, 24, and 36 hours after surgical procedure, when patients were moving, were significantly lower than the scores in group C (all P<.05). CONCLUSIONS In patients who underwent video-assisted thoracoscopic surgery, CRIB led to improved quality of recovery and postoperative analgesia. (C) 2022 by The Society of Thoracic Surgeons

Background. Thoracic surgery is one of the most painful surgical steps. An important tool for managing postoperative pain is effective postoperative analgesia. This research aimed at comparing the analgesic roles of three new fascial block techniques in the postoperative period after video-helped thoracoscopic operation (VATS). Methods. We randomly allocated ninety patients into three teams experiencing ultrasound-directed serratus plane block, erector spinae plane block, and the rhomboid intercostal block, respectively. 0.4% ropivacaine of 20 mL was received by all groups. Outcomes. At 0-12 hours, sufentanil consumption was significantly lower in the RIB (35.2 +/- 3.3 mg) and ESP (35.4 +/- 2.8 mg) groups than that in the SAB (43.3 +/- 2.7 mg) group P < 0.001, and no obvious diversity in sufentanil consumption was shown between the RIB and ESP groups P=0.813. At 12-24 hours, sufentanil consumption was greatly lower in the RIB and ESP groups than that in the SAB group P < 0.001, and no great diversity in sufentanil consumption was found between the RIB and ESP groups P=0.589. No great diversity in sufentanil consumption was shown between the RIB (50.4 +/- 1.4 mg), ESP (50.4 +/- 1.5 mg), and SAB (51.0 +/- 1.7 mg) groups at 24-48 hours P=0.192. At 6, 12, 18, and 24 hours, the postoperative dynamic NRS scores were significantly lower in the RIB and ESP groups than in the SAB group (P < 0.05 for all contrasts). Nevertheless, no great diversity was observed in postoperative pain marks at 0.5, 1, 3, 6, 12, 18, 24, 36, and 48 hours after the surgery across the three groups. No statistical diversity was found in the postoperative NRS mark between groups RIB and ESP within 48 hours after surgery in case of active patients (P < 0.05 for all contrasts). At 24 hours after surgery, a significant difference in IL-1 beta and IL-6 inflammatory factor concentrations was found between RIB and ESP compared with SAB block (P < 0.05 for all contrasts). However, no great diversities were observed in IL-1 beta, and IL-6 inflammatory factor concentrations between RIB, ESP, and SAB at 24 hours preoperatively and at 48 hours postoperatively (P < 0.05 for all comparisons). Conclusion. The dosage of sufentanil can be effectively reduced by ultrasound-directed rhomboid intercostal block and erector spinae plane block within 24 hours after VATS surgery, and pain can be relieved effectively within 24 hours by comparing with serratus plane block.

Background Positive-pressure ventilation (PPV) delivered via a facemask during anesthesia induction can result in gastric content being inhaled into the lungs. We hypothesized that the real-time ultrasound left paratracheal esophagus monitoring could more effectively reduce air entry into the stomach than real-time ultrasound monitoring of the gastric antrum (GA). Methods Patients were divided into two groups: study (S; n=30) and control (C; n=30) groups. During the induction of general anesthesia, mask ventilation adopts a pressure control mode. The initial ventilation pressure of both groups was 15 cmH2O. Before anesthesia induction, an ultrasonic probe was used to monitor the cross-sectional area (CSA) of the GA and the presence of gas in the stomach. During and after anesthesia induction, group S used a high-frequency ultrasound probe to observe the entry of air from the left paratracheal esophagus into the GA. The ventilation pressure was gradually reduced over time until no esophageal air was found. In group C, the ventilatory pressure was set maintained at 15 cmH2O and the CSA of the GA and air intake were monitored using an ultrasonic probe. Results Before and after PPV, the CSA of the GA in group S decreased (P<0.001), whereas the CSA in group C increased (P=0.002). The GA CSA in group C after PPV was larger than in group S after PPV (P=0.002). The proportion of patients who experienced intragastric air intake in group S (23.3%) was significantly lower than that in group C (66.7) (P=0.001). Conclusion Compared with ultrasound monitoring of the GA, real-time ultrasound detection of LPEOAE into the GA during anesthesia induction was more effective, more sensitive, significantly reduced the prevalence of intragastric air intake, and provided sufficient tidal volume and oxygen for patients.

Delayed paralysis occurs within some patients suffered from ischemic spinal cord injury (ISCI) due to the aorta occlusion during the repair surgery of thoracic and thoracoabdominal aortic aneurysms. Although mild hypothermia has been reported to improve ISCI and prolong the tolerance of rats to ISCI without inducing immediate paralysis, the mechanism remains unclear. Herein, the study revealed that the mild hypothermia treatment indeed partially improved the ISCI in rats caused by cross-clamping at the descending aorta. ISCI induced the excessive activation of microglia and moderate autophagy in the spinal cord tissues of rats, while mild hypothermia significantly induced autophagy and reversed the excessive activation of microglia in the spinal cord tissues of rats. In OGD-stimulated mouse microglia BV-2 cells, the excessive activation of microglia and moderate autophagy were also observed; in the rapamycin-treated OGD model in BV-2 cells, autophagy was significantly enhanced whereas the excessive activation of microglia was reversed. In both in vivo ISCI model in rats and in vitro OGD model in BV-2 cells, the PI3K/AKT/mTOR pathway showed to be inhibited, whereas the PI3K/AKT/mTOR pathway was further inhibited by mild hypothermia in ISCI rats or rapamycin treatment in OGD-stimulated BV-2 cells. In conclusion, enhanced autophagy might be the mechanism of inhibited microglia activation by hypothermia treatment in ISCI rats and by rapamycin treatment in OGD-stimulated BV-2 cells. Autophagy could be enhanced through inhibiting the PI3K/AKT/mTOR pathway.

Background: Prostatic hyperplasia is a physiological aging process in men. After transurethral resection of prostate (TURP), visceral pain is the main cause. The effective postoperative analgesia can reduce the occurrence of postoperative complications. This study mainly studied the analgesic effect of quadratus lumborum block (QLB) on TURP. Methods: We divided 62 patients undergoing TURP into 2 groups using a random number table method (QLB 2 group and non-QLB [control] group). Patients in the QLB group underwent ultrasound-guided posterior QLB with 20 mL of 0.25% ropivacaine on each side, and those in the control group received only general anesthesia. The primary outcome for this study was the consumption analgesic pump during 0 to 24 hours. The secondary outcomes included the first pressing time of analgesic pump during 0 to 24 hours, the pain at rest and when coughing at 1, 4, 8, 12, and 24 hours post-operation as measured with a visual analogue scale for pain, length of the hospital stay, and complications (nausea and vomiting, dizziness, and abdominal distension). Results: Patients in the QLB group presented less consumption, later first pressing time of analgesic pump during 0 to 24 hours after surgery lower visual analogue scale scores at 1, 4, 8, 12, and 24 hours postsurgery than those in the control group. Moreover, their mean length of hospital stay was shorter (P = .023), and they experienced less postoperative complications than the patients in the control group. Conclusions: Ultrasound-guided QLB in TURP provided a significant analgesic effect in our patients the first day after surgery. This analgesic model may improve the postoperative recovery after TURP.

Background and objectives Breast cancer is one of the most commonmalignant tumors in women. Herein, we compared the analgesic efficacy ofultrasound-guided rhomboid intercostal nerve block , erector spinaeplane block and serratus plane block after modified radical mastectomyof unilateral breast cancer. Methods: A total of 90 patients whounderwent modified radical mastectomy for unilateral breast cancer wereselected. patients were randomly allocated into three groups receivingultrasound-guided serratus plane block, erector spinae plane block, andthe rhomboid intercostal block group. All groups received 20 mL 0.5%ropivacaine. Within 24 hours after operation, the patient receivedintravenous injection of tramadol 1-2 mg/kg to relieve pain in thesurgical ward. Results: The dosage of tramadol 24-hours postoperativelyin the rhomboid intercostal block and erector spinae plane block groupswas significantly lower than that in serratus plane block group (P< 0.001). There was no statistical difference in tramadolconsumption between the erector spinae plane block and rhomboidintercostal block groups within 24 hours (P = 0.676). The numericalrating scale scores in the erector spinae plane block and rhomboidintercostal block groups at 0.5, 1, 3, 6, 12, 18, and 24 hourspostoperatively once patients were active were significantly lower thanin the serratus plane block group (P < 0.05 for allcomparisons); however, The numerical rating scale scores betweenrhomboid intercostal block and erector spinae plane block groups did notdiffer significatively within 24 hours after surgery when patients wereactive. Conclusions: Ultrasound-guided rhomboid intercostal block anderector spinae plane block can reduce the dosage of tramadol and NRSscore compared with serratus plane block after modified radicalmastectomy.

BackgroundRhomboid intercostal block (RIB) and Rhomboid intercostal block with sub-serratus plane block (RISS) are the two types of plane blocks used for postoperative analgesia after video-assisted thoracoscopic surgery (VATS). This prospective randomized controlled trial was performed to analyze the postoperative analgesic effects of ultrasound-guided RIB block and RISS block after video-assisted thoracoscopic surgery. MethodsNinety patients aged between 18 and 80 years, with American Society of Anesthesiologists physical status Classes I-II and scheduled for elective unilateral VATS were randomly allocated into three groups. In group C, no block intervention was performed. Patients in group RIB received ultrasound-guided RIB with 20-mL 0.375% ropivacaine and those in group RISS received ultrasound-guided RIB and serratus plane block using a total of 40-mL 0.375% ropivacaine. All patients received intravenous sufentanil patient-controlled analgesia upon arrival in the recovery room. Postoperative sufentanil consumption and pain scores were compared among the groups. ResultsThe dosages of sufentanil consumption at 24 h after the surgery in the RIB and RISS groups were significantly lower than that in group C (p < 0.001 and p < 0.001 for all comparisons, respectively), the postoperative Numerical Rating Scale (NRS) scores in the RIB and RISS groups at 0.5, 1, 3, 6, 12, 18, and 24 h after surgery when patients were at rest or active were significantly lower than that in group C (p < 0.05 for all comparisons). The required dosage of sufentanil and time to first postoperative analgesic request in groupRISS were less than those in the group RIB at 24 h after the surgery (p < 0.001 and p < 0.001 for all comparisons, respectively). Similarly, the Numerical Rating Scale scores for group RISS at 12, 18, and 24 h after the surgery when the patients were active were significantly lower than those for group RIB (p < 0.05 for all comparisons). ConclusionBoth ultrasound-guided RIB block and RISS block can effectively reduce the demand for sufentanil within 24 h after VATS, and less sufentanil dosage is needed in patient with RISS block. Ultrasound-guided RIB block and RISS block can effectively relieve pain within 24 h after VATS, and RISS block is more effective.

Background and Objectives Patients with femoral neck fractures often suffer severe pain. This randomized controlled clinical study compared the effect of femoral nerve block (FNB) and fascia iliaca compartment block (FICB) in this population. Patients and Methods Forty-six patients were randomly assigned to one of the two groups: FNB group (femoral nerve block, n=23) or FICB group (fascia iliaca compartment block, n=23). Before positioning for spinal anesthesia, patients received FNB with 15 mL of 0.5% ropivacaine or FICB with 40 mL of 0.5% ropivacaine. Pain was evaluated using a visual analogue scale (VAS) at rest and during hip flexion after admission to the operation room; at 3, 5, 8, and 10 min after analgesia intervention; and during positioning for spinal anesthesia. Positioning was attempted after 10 min of analgesia intervention in each group. Time required to perform spinal anesthesia, quality of positioning, and patient satisfaction were documented. Results The VAS scores in the FNB group were significantly lower than those in FICB group at 3 and 5 min after analgesia intervention (P=0.000). However, there were no significant differences in VAS between groups at 8 or 10 min or during positioning. Conclusion FNB and FICB produce similar analgesic effects in patients with femoral neck fractures, but FNB has a more rapid onset of pain relief.

Background: Pectoral nerve block type I (PECS I Block) and type II (PECS II Block) with ropivacaine are relatively new analgesic methods for breast-cancer surgery. We evaluated the safety and efficacy of different concentrations of ropivacaine given in the same volume for the PECS II Block in patients undergoing modified radical mastectomy (MRM). Patients and Methods: One hundred and twenty women undergoing elective MRM who met inclusion criteria were divided randomly into four groups of 30: control group without PECS II Block and R-0.2%, R-0.3%, and R-0.4% groups, who received general anesthesia plus the PECS II Block with ropivacaine at 0.2%, 0.3%, and 0.4%, respectively, in a volume of 40 mL. Results: The postoperative numerical rating scale (NRS) pain score at rest and active was significantly higher in the control group than that in the three ropivacaine groups (P<0.05 for all), and the postoperative NRS score in the R-0.3% group and R-0.4% group at 12, 24, and 48 h postoperatively were significantly lower than that in the R-0.2% group (P<0.05 for all); there was no significant difference between the R-0.3% group and R-0.4% group. The time when pain was first felt after MRM, the total number of complaints during 3, 6, 12, 24, and 48 h after MRM, and the total analgesic requirement (tramadol consumption) during the first 24 h postoperatively in the R-0.3% group and R-0.4% group were significantly lower than those in the control group and R-0.2% group (P<0.05 for all); there was no significant difference between the R-0.3% group and R-0.4% group. Conclusion: A dose of 0.3% ropivacaine was the optimal concentration for a PECS II Block for patients undergoing MRM because it provided efficacious analgesia during and >48 h after MRM. Increasing the ropivacaine concentration did not improve the analgesia of the PECS II Block significantly.

Background: This study aimed to compare the quadratus lumborum block (QLB) method with transversus abdominis plane block (TAPB) for postoperative pain management in patients undergoing laparoscopic colorectal surgery. Methods: Seventy-four patients scheduled for laparoscopic colorectal surgery were randomly assigned into 2 groups. After surgery, patients received bilateral ultrasound-guided single-dose of QLB or TAPB. Each side was administered with 20 ml of 0.375% ropivacaine. All patients received sufentanil as patient-controlled intravenous analgesia (PCIA). Resting and moving numeric rating scale (NRS) were assessed at 2, 4, 6, 24, 48 hours postoperatively. The primary outcome measure was sufentanil consumption at predetermined time intervals after surgery. Results: Patients in the QLB group used significantly less sufentanil than TAPB group at 24 and 48 hours (P < .05), but not at 6 hours (P= .33) after laparoscopic colorectal surgery. No significant differences in NRS results were found between the two groups at rest or during movement (P> .05). Incidence of dizziness in the QLB group was lower than in TAPB group (P < .05). Conclusions: The QLB is a more effective postoperative analgesia as it reduces sufentanil consumption compared to TAPB in patients undergoing laparoscopic colorectal surgery.